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Degradation-controllable magnesium phosphate cement and preparation method and application thereof

A technology of magnesium phosphate bone cement and potassium dihydrogen phosphate, which is applied in medical science, prostheses, tissue regeneration, etc., can solve the problem of difficulty in matching the metabolic rate with the growth rate of new bone, unsatisfactory speed and controllable degradation, and water resistance. Insufficient performance and other problems, to achieve good application prospects, controllable degradation rate, high compressive strength

Active Publication Date: 2016-07-06
HENAN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

MPBC is a human hard tissue repair material with excellent performance. Its application will bring the bone repair effect to a new level. However, the speed of its chemical combination with bone tissue and its controllable degradation are not ideal, and some materials degrade too quickly. Some are difficult to degrade, which makes it difficult for the metabolism rate of materials in the body to match the growth rate of new bone; in addition, MPBC has insufficient water resistance. fall quickly

Method used

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  • Degradation-controllable magnesium phosphate cement and preparation method and application thereof
  • Degradation-controllable magnesium phosphate cement and preparation method and application thereof
  • Degradation-controllable magnesium phosphate cement and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] a. Put the analytically pure magnesium hydroxide at 1500°C, heat it for 8 hours, cool it naturally in the furnace, grind it, and pass it through a 200-mesh sieve to obtain the required magnesium oxide powder;

[0037] b. Weigh raw materials by mass percentage: magnesia powder 65%, potassium dihydrogen phosphate 15%, borax 7%, deionized water 13%;

[0038] c, the potassium dihydrogen phosphate weighed in step b, borax and deionized water are fully mixed and stirred;

[0039] d. Add the magnesium oxide powder weighed in step b to the mixed slurry in step c, and quickly and fully mix and stir;

[0040] e. Put the slurry prepared in step d into a mold for molding, and place it in an environment of 20±2°C and a relative humidity of 50±5% for curing to obtain the controllable degradable magnesium phosphate bone cement.

Embodiment 2

[0042] a. Put the analytically pure magnesium hydroxide at 1500°C, heat it for 8 hours, cool it naturally in the furnace, grind it, and pass it through a 200-mesh sieve to obtain the required magnesium oxide powder;

[0043] b. Weigh raw materials according to mass percentage: 65% magnesium oxide powder, 15% potassium dihydrogen phosphate, 7% borax, 12% deionized water, 1% chitosan;

[0044] C, the potassium dihydrogen phosphate weighed in step b, borax, chitosan and deionized water are fully mixed and stirred;

[0045]d. Add the magnesium oxide powder weighed in step b to the mixed slurry in step c, and quickly and fully mix and stir;

[0046] e. Put the slurry prepared in step d into a mold for molding, and place it in an environment of 20±2°C and a relative humidity of 50±5% for curing to obtain the controllable degradable magnesium phosphate bone cement.

Embodiment 3

[0048] a. Put the analytically pure magnesium hydroxide at 1500°C, heat it for 8 hours, cool it naturally in the furnace, grind it, and pass it through a 200-mesh sieve to obtain the required magnesium oxide powder;

[0049] b. Raw materials were weighed according to mass percentage: magnesia powder 65%, potassium dihydrogen phosphate 15%, borax 7%, deionized water 11%, chitosan 1%, hydroxypropyl methylcellulose 1%;

[0050] c, the potassium dihydrogen phosphate weighed in step b, borax, chitosan, hydroxypropyl methylcellulose and deionized water are fully mixed and stirred;

[0051] d. Add the magnesium oxide powder weighed in step b to the mixed slurry in step c, and quickly and fully mix and stir;

[0052] e. Put the slurry prepared in step d into a mold for molding, and place it in an environment of 20±2°C and a relative humidity of 50±5% for curing to obtain the controllable degradable magnesium phosphate bone cement.

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Abstract

Provided are degradation-controllable magnesium phosphate cement and a preparation method and application thereof.The degradation-controllable magnesium phosphate cement is characterized by being prepared from, by mass, 35%-65% of magnesia powder, 15%-40% of monopotassium phosphate, 2%-7% of borax, 10%-25% of deionized water, 0%-1% of chitosan and 0%-1% of hydroxypropyl methyl cellulose.Compared with an existing material, the degradation-controllable magnesium phosphate cement is high in strength, good in biological activity and controllable in degradation rate and has a good application prospect in the field of biomedical materials by serving as a bone repair material.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method and application of a controllable degradable magnesium phosphate bone cement. Background technique [0002] Bone is one of the most important tissues in the human body and plays an important role in protecting internal organs and so on. Bone defects caused by traffic accidents, industrial injuries, sports injuries, diseases, and population aging are common diseases in orthopedics, which require a large number of high-quality biomedical materials and devices for clinical healing and repair. The global demand for bone repair materials and their products has maintained a growth rate of about 20% in recent years. As a country with a large population, my country's demand for bone repair materials is growing more significantly. Therefore, the development of biological bone repair materials has important social significance and huge economic benefits....

Claims

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Application Information

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IPC IPC(8): C04B28/34A61L27/12A61L27/02A61L27/20A61L27/58
CPCA61L27/025A61L27/12A61L27/20A61L27/58A61L2430/02C04B28/344C04B14/304C04B22/0013C04B24/38C04B24/383C08L5/08C08L1/284
Inventor 廖建国段星泽谢玉芬张磊刘静贤李艳群张永祥李磊明黄亮张猛
Owner HENAN POLYTECHNIC UNIV
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