Polyhydroxy fatty acid ester blood vessel stent and making method thereof

A technology of polyhydroxyalkanoate and vascular stents, which is applied in the field of biomedical engineering, can solve the problems of poor affinity between blood vessels and cells, the degradation speed cannot match the tissue regeneration speed, and the mechanical properties and suturing performance need to be improved. Achieve the effects of improved cell adhesion, good biocompatibility, and good biodegradability

Inactive Publication Date: 2006-06-07
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The blood vessels constructed by such materials have poor affinity with cells, and the degradation rate cannot match the tissue regeneration rate
Although the biocompatibility, cell adhesion and degradation speed of blood vessels prepared by the new biodegradable material polyhydroxyalkanoate (PHA) have been significantly improved compared with traditional materials, the mechanical properties and suture Performance can still be improved

Method used

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  • Polyhydroxy fatty acid ester blood vessel stent and making method thereof
  • Polyhydroxy fatty acid ester blood vessel stent and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 80% polyhydroxybutyrate-valerate (PHB-HV) and 20% polyethylene glycol / polybutylene terephthalate (PEG-CO-PBT) copolymer blended to prepare a diameter of 8mm, a length of 50mm vascular stent.

[0033] (1) Preparation of blend solid film

[0034] ① Mix 80% polyhydroxybutyrate-valerate (PHB-HV) with 20% polyethylene glycol / polybutylene terephthalate (PEG-CO-PBT) and chloroform, heat in a water bath and fully Stir to prepare a solution with a uniform concentration of 0.05g / ml;

[0035] ②Using the method of cast film formation, cool the solution prepared in ① and pour it into a pair of petri dishes with a diameter of 10cm (the diameter is adjustable, the same below), and fasten the upper and lower evaporating dishes to let the chloroform volatilize naturally. Prepare a solid film, and control the amount of raw materials so that the film thickness is 1 to 2 mm;

[0036] (2) Preparation of blend porous membrane

[0037] ① Pass the salt through a standard sieve to select Na...

Embodiment 2

[0051] A vascular stent with a diameter of 3 mm and a length of 10 mm was prepared using 70% polyhydroxybutyrate (PHB) and 30% polyethylene glycol / polybutylene terephthalate (PEG-CO-PBT).

[0052] (1) Preparation of blend solid film

[0053] The preparation method is the same as the method for preparing the PHB-HV / PEG-CO-PBT solid film in Example 1, except that PHB-HV / PEG-CO-PBT is replaced by PHB / PEG-CO-PBT, wherein PHB accounts for 70%, PEG-CO-PBT accounts for 30%, the solution concentration is 0.03g / ml, and the diameter of the petri dish is adjusted to 6cm;

[0054] (2) Preparation of blend porous membrane

[0055] The preparation method is the same as the method for preparing the PHB-HV / PE-CO-PBT porous membrane in Example 1, except that PHB-HV / PEG-CO-PBT is replaced by PHB / PEG-CO-PBT, wherein PHB accounts for 70%, PEG-CO-PBT accounted for 30%, the added NaCl was 15 times the total mass of the blend, and the particle size of NaCl was adjusted to 200-300 μm; the diameter ...

Embodiment 3

[0061] Using 60% polyhydroxybutyrate-hexanoate (PHB-HH) and 40% polyethylene glycol / polybutylene terephthalate (PEG-CO-PBT) blend to prepare 100mm vascular stent.

[0062] (1) Blend solid film preparation

[0063] The preparation method is the same as the method for preparing the PHB-HV / PEG-CO-PBT solid film in Example 1, except that PHB-HV / PEG-CO-PBT is replaced by PHB-HH / PEG-CO-PBT, wherein PEG-CO -PBT accounts for 40% of the total mass, the solution concentration is 0.06g / ml, and the diameter of the petri dish is changed to 19cm;

[0064] (2) Preparation of blend porous membrane

[0065] The preparation method is the same as the method for preparing the PHB-HV / PEG-CO-PBT porous membrane in Example 1, except that PHB-HV / PEG-CO-PBT is replaced by PHB-HH / PEG-CO-PBT, wherein PEG-CO - PBT accounts for 40% of the total mass, the added NaCl is 20 times the total mass of the blend, and the particle size of NaCl is changed to 200-300 μm;

[0066] (3) Preparation of blend reinfor...

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Abstract

The present invention relates to a polyhydroxy alkanoates blood vessel support and its preparation method. Said blood vessel support is made of porous internal membrane, solid external membrane and reinforcing rib. The reinforcing rib is winded around the surface layer of solid external membrane in the form of strip. The described porous internal membrane, solid external membrane and reinforcing rib are made up by using one of polyhydroxy butyrate, polyhydroxybutyric acid-pentanoate or polyhydroxybutyric acid-caproate or their blend and polyglycol-polybutylene glycol terephthalate copolymer blend. Said invention possesses good biological compatibility, anticoagulant property, cell adhesion and proper degrading speed, high mechanical strength and suture strength.

Description

technical field [0001] The invention relates to a blood vessel stent made by blending polyhydroxyalkanoate and polyethylene glycol / polybutylene terephthalate copolymer and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique: [0002] At present, the main medical method for diseased blood vessels with a diameter of no more than 6mm is to use autologous blood vessels as a detour bypass to replace diseased blood vessels, but because many patients do not have appropriate and sufficient blood vessels for detour bypasses, synthetic materials are used to prepare blood vessels. Bracket ideas. The basic idea of ​​using a blood vessel made of synthetic material as a detour is to adsorb tissue cells on a scaffold material with good biocompatibility that can be gradually degraded and absorbed in the human body, and provide nutrients to the cells to expand them. While the scaffold material is gradually degraded and absorbed by t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M29/00A61F2/06A61L31/04A61L27/14
Inventor 胡平戈钧童晓岚郇春艳
Owner TSINGHUA UNIV
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