Polylactic-acid-modified magnesium alloy medical composite material and preparation method thereof

A composite material and magnesium alloy technology, which is applied in the field of polylactic acid modified magnesium alloy medical composite material and polylactic acid modified magnesium alloy medical composite material, can solve the problem that the corrosion resistance and biocompatibility cannot be taken into account, and the risk is difficult to control. , the effect is not ideal and other problems, to achieve the effect of good cell adhesion and proliferation promotion, improved corrosion resistance, good biodegradability

A composite material and magnesium alloy technology, which is applied in the field of polylactic acid modified magnesium alloy medical composite material and polylactic acid modified magnesium alloy medical composite material, can solve the problem that the corrosion resistance and biocompatibility cannot be taken into account, and the risk is difficult to control. , the effect is not ideal and other problems, to achieve the effect of good cell adhesion and proliferation promotion, improved corrosion resistance, good biodegradability

CN107185032AActive Publication Date: 2017-09-22广州雄俊智能科技有限公司
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  • Polylactic-acid-modified magnesium alloy medical composite material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of the polylactic acid modified magnesium alloy medical composite material of the present embodiment comprises the following steps:

[0042] 1) Take a magnesium alloy substrate with a thickness of 2.0 mm, and carry out micro-arc oxidation treatment on the surface of the magnesium alloy substrate by using a double electrolyte system of phosphate and silicate. The micro-arc oxidation treatment is a constant current treatment, and the current density is 6A / dm 2 , the power frequency is 600Hz, the duty cycle is 10%, and the treatment time is 6min; after the micro-arc oxidation is completed, rinse with deionized water, dry, and then immerse in a silane coupling agent solution with a mass concentration of 2.0%. Carry out coupling treatment at 40°C for 100 minutes, take it out and air-dry to obtain a silane coupling matrix;

[0043] 2) getting chitosan to be dissolved in acetic acid aqueous solution to make mass concentration is the chitosan solution o...

Embodiment 2

[0048] The preparation method of the polylactic acid modified magnesium alloy medical composite material of the present embodiment comprises the following steps:

[0049] 1) Take a magnesium alloy substrate with a thickness of 2.0 mm, and carry out micro-arc oxidation treatment on the surface of the magnesium alloy substrate using a phosphate and silicate double electrolyte system. The micro-arc oxidation treatment is a constant current treatment, and the current density is 3A / dm 2 , the power frequency is 600Hz, the duty cycle is 10%, and the treatment time is 10min; after the micro-arc oxidation is completed, rinse with deionized water, dry, and then immerse in a silane coupling agent solution with a mass concentration of 1.0%. Carry out coupling treatment at 50°C for 80 minutes, take it out and air-dry to obtain a silane coupling matrix;

[0050] 2) dissolving chitosan in aqueous acetic acid to make a chitosan solution with a mass concentration of 30g / L, adding surfactant...

Embodiment 3

[0055] The preparation method of the polylactic acid modified magnesium alloy medical composite material of the present embodiment comprises the following steps:

[0056] 1) Take a magnesium alloy substrate with a thickness of 2.0 mm, and carry out micro-arc oxidation treatment on the surface of the magnesium alloy substrate using a phosphate and silicate double electrolyte system. The micro-arc oxidation treatment is a constant current treatment, and the current density is 4A / dm 2 , the power frequency is 600Hz, the duty cycle is 10%, and the treatment time is 4min; after the micro-arc oxidation is completed, rinse with deionized water, dry, and then immerse in a silane coupling agent solution with a mass concentration of 1.0%. Carry out coupling treatment at 45°C for 90 minutes, take it out and air-dry to obtain a silane coupling matrix;

[0057] 2) getting chitosan to be dissolved in acetic acid aqueous solution to make mass concentration is the chitosan solution of 25g / L...

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Abstract

The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.

Description

technical field [0001] The invention belongs to the technical field of medical composite materials, in particular to a polylactic acid modified magnesium alloy medical composite material, and also relates to a preparation method of the polylactic acid modified magnesium alloy medical composite material. Background technique [0002] Fracture is a high-incidence orthopedic disease. Effective internal fixation can prevent the displacement of the broken bone and assist its growth and healing. At present, the bone fixation materials in clinical application are mainly metal materials, such as stainless steel, titanium-based alloys, cobalt-based alloys, shape memory alloys, noble metals and pure metals such as niobium and zirconium. These metal implant materials have excellent mechanical properties, but there are also Many deficiencies, such as being corroded and releasing harmful metal ions in a physiological environment, causing local inflammation and tissue necrosis; the elasti...

Claims

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Application Information

Patent Timeline
22 Sep 2017
Publication
CN107185032A
IPC
A61L27/04; A61L27/34; A61L27/50; A61L27/58; C25D11/30
CPC
A61L27/047; A61L27/34; A61L27/50; A61L27/58; A61L2400/18; A61L2420/02; A61L2420/06; A61L2430/02
Inventors
魏科峰