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Hydroxyapatite/polyurethane porous bone repair material with shape memory

A technology of hydroxyapatite and repair materials, applied in medical science, tissue regeneration, prostheses, etc., can solve the problems of mismatching rate of degradation rate and rate of new bone formation, poor biocompatibility, complex molding process, etc., to achieve Good osteoinductivity, improved elasticity, good biocompatibility

Inactive Publication Date: 2021-09-10
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the scaffold material can improve the osteoblast differentiation rate of MG-63 cells, it still has some defects, such as poor elasticity and limited forming ability.
Through the above research, we found that there are some problems in most bone repair materials, such as short retention time in the body, complex molding process, poor biocompatibility, mismatch between the rate of degradation and the rate of new bone formation, etc.

Method used

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  • Hydroxyapatite/polyurethane porous bone repair material with shape memory
  • Hydroxyapatite/polyurethane porous bone repair material with shape memory
  • Hydroxyapatite/polyurethane porous bone repair material with shape memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The hydroxyapatite / polyurethane porous composite bone repair material with shape memory provided in this example is composed of polycaprolactone, polytetrahydrofuran and hydroxyapatite, and the content of hydroxyapatite is 0% by mass percentage. The rest is the total content of polycaprolactone and polytetrahydrofuran, wherein the mass ratio of polycaprolactone and polytetrahydrofuran is 1:1; the molecular weight of polycaprolactone is 4000, and the molecular weight of polytetrahydrofuran is 3000. The specific implementation steps are as follows:

[0024] (1) take by weighing respectively 20 grams of polycaprolactone and 20 grams of polytetrahydrofuran with an electronic balance;

[0025] (2) Under a nitrogen environment, dissolve the weighed polycaprolactone and polytetrahydrofuran in dichloromethane, then add hydroxyapatite and mix uniformly at 80 ° C, and continue stirring to obtain a uniformly dispersed mixture; 300r / min;

[0026] (3) After mixing evenly, add 4ml of...

Embodiment 2

[0033] The hydroxyapatite / polyurethane porous composite bone repair material with shape memory provided in this example is composed of polycaprolactone, polytetrahydrofuran and hydroxyapatite, and the content of hydroxyapatite is 10% by mass percentage. The rest is the total content of polycaprolactone and polytetrahydrofuran, wherein the mass ratio of polycaprolactone and polytetrahydrofuran is 1:1; the molecular weight of polycaprolactone is 4000, and the molecular weight of polytetrahydrofuran is 3000. The specific implementation steps are as follows:

[0034] (1) each take by weighing 20 grams of polycaprolactone and polytetrahydrofuran and the hydroxyapatite of 4.444 grams with electronic balance;

[0035] (2) Under a nitrogen environment, dissolve the weighed polycaprolactone and polytetrahydrofuran in dichloromethane, then add hydroxyapatite and mix uniformly at 80 ° C, and continue stirring to obtain a uniformly dispersed mixture; 200r / min;

[0036] (3) After mixing ...

Embodiment 3

[0042] The hydroxyapatite / polyurethane porous composite bone repair material with shape memory provided in this example is composed of polycaprolactone, polytetrahydrofuran and hydroxyapatite, and the content of hydroxyapatite is 20% by mass percentage. The rest is the total content of polycaprolactone and polytetrahydrofuran, wherein the mass ratio of polycaprolactone and polytetrahydrofuran is 1:1; the molecular weight of polycaprolactone is 4000, and the molecular weight of polytetrahydrofuran is 3000. The specific implementation steps are as follows:

[0043] (1) each take by weighing 20 grams of polycaprolactone and polytetrahydrofuran and 10 grams of hydroxyapatite with electronic balance;

[0044] (2) Under a nitrogen environment, dissolve the weighed polycaprolactone and polytetrahydrofuran in dichloromethane, then add hydroxyapatite and mix uniformly at 80 ° C, and continue stirring to obtain a uniformly dispersed mixture; 250r / min;

[0045] (3) After mixing evenly,...

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Abstract

The invention relates to a biological material for bone injury repair. A hydroxyapatite / polyurethane porous bone repair material with shape memory is mainly prepared by a gas foaming method. The porous bone repair material with the shape memory function is prepared from polycaprolactone and polytetrahydrofuran which are equal in mass and hydroxyapatite in different proportions. The bone repair material shows a good shape memory effect at 37 DEG C, the shape recovery rate of the bone repair material can reach 100%, the bone repair material can change the shape in an extremely short time to fill a defect part, and the material can adapt to and gradually degrade along with repair closing of tissue growth. In addition, the bone repair material also has the advantages of high porosity, good biocompatibility, non-toxic and harmless degradation products and the like, the preparation method is simple, the cost is low, and an effective and feasible way is provided for preparing the hydroxyapatite / polyurethane porous bone repair material with shape memory for the field of biological materials.

Description

technical field [0001] The invention relates to a hydroxyapatite / polyurethane porous composite bone repair material with shape memory and a preparation method thereof, belonging to the field of biomedical materials for bone damage repair. Background technique [0002] Bone tissue engineering has significant advantages in the application of clinical bone defect treatment, and has attracted extensive attention from domestic and foreign scholars in recent years. Bone defects caused by factors such as trauma, malignant tumors, degeneration, infection, aging, and congenital diseases are common clinical problems that are difficult to solve. The main method for clinical treatment of bone defects is autologous bone grafting or xenograft bone grafting, or the replacement of artificial bone materials such as metal alloys. Although autologous bone has the characteristics of strong bone formation ability and easy healing, its source is limited; while allograft bone is antigenic, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/50A61L27/56A61L27/58
CPCA61L27/46A61L27/50A61L27/56A61L27/58A61L2430/02C08L75/04
Inventor 王立曾西洋罗昆陈小虎李俊峰张佩聪周世一
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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