A kind of triptorelin sustained-release microparticles and preparation method thereof

A slow-release microparticle and microparticle technology, which is applied in the direction of diseases, antineoplastic drugs, bulk delivery, etc., can solve the problems of sudden release, poor uniformity of microspheres, low drug loading and encapsulation efficiency, and achieve simple process, Good plasticity and good drug loading effect
CN105267153BActive Publication Date: 2018-05-11SHANGHAI SOHO YIMING PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI SOHO YIMING PHARMA
Publication Date
2018-05-11

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Abstract

The invention relates to drug slow-release microparticles, in particular to triptorelin sustained-release microparticles and a preparation method thereof. The composition includes the following components by weight percentage: 0.5%-20% of triptorelin, 79%-99% of PLGA, and 0.1%-1% of poloxamer. The preparation method of the above-mentioned triptorelin sustained-release microparticles of the present invention comprises mixing each component and sending it into a hot-melt extruder, where heating and melting, extrusion and low-temperature pulverization are carried out. The praline sustained-release microparticles of the present invention have good shape, high encapsulation efficiency of the microparticles, good drug loading capacity and stable release. The synthesis process is simple, the product itself is non-toxic, and the product after degradation is non-toxic and stable in quality.
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Description

technical field

[0001] The invention relates to drug slow-release microparticles, in particular to triptorelin sustained-release microparticles and a preparation method thereof. Background technique

[0002] Triptorelin is a synthetic gonadotropin-releasing hormone analog, which can be effectively used for diseases such as prostate cancer, endometriosis, and precocious puberty. Conventional triptorelin preparations have short biological half-life, poor preparation stability, difficult absorption after oral administration, and large side effects after taking the medicine.

[0003] Using the biodegradable material PLGA as the skeleton material, the triptorelin drug is encapsulated into microspheres (granules). As a sustained and controlled release preparation, the common preparation techniques include emulsification-liquid drying, spray drying, separation method, etc., the triptorelin microspheres have achieved sustainable drug release. However, the uniformity of the microsp...

Claims

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