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31results about How to "Osteoinductive" patented technology
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Calcium phosphate bone induction biological ceramic stent based on photocuring 3D printing technology and preparation method thereof
PendingCN109650909AHigh solid contentLow viscosityAdditive manufacturing apparatusCeramic shaping apparatusCalcium biphosphateDispersity
The invention discloses a calcium phosphate bone induction biological ceramic stent based on a photocuring 3D printing technology and a preparation method thereof, and belongs to the field of biomedical materials. Through the method, ceramic paste which is high in content of solid, low in viscosity and good in dispersity and fluidity can be effectively prepared. Through the photocuring 3D printingtechnology and follow-up degreasing sintering, the bone induction porous calcium phosphate ceramic stent with an internal penetrating pore structure can be prepared, wherein the shape, size, porosityand macroscopic morphology of the bone induction porous calcium phosphate ceramic stent can be accurately controlled, and the bone induction porous calcium phosphate ceramic stent is used for bone tissue repairing and filling and individualized repairing.
Owner:SICHUAN UNIV
Preparation method of coating with bone induction and antibiosis functions on surface of medical metal
InactiveCN103203039AImprove bioavailability in vivoSmall toxicityCoatingsProsthesisAntibiosisNanoparticle coating
The invention discloses a method for preparing a nanoparticle coating with the bone induction and antibiosis functions on the surface of a medical metal. According to the method, nanoparticles with different electric properties as used as a carrier, the nanoparticles are formed by mutual crosslinking of high-molecular polymers, and growth factors and antibiotics are respectively loaded in the process of preparing the nanoparticles with dissimilar electric properties, wherein factors and factor-friendly polyanions are sufficiently mixed to react first and are then immobilized into the nanoparticles through ionic crosslinking; and amino-containing antibiotics are grafted to a polyaldehyde anionic polymer through chemical crosslinking first and are then loaded into the nanoparticles through ionic crosslinking. The two types of nanoparticles are alternately assembled on the surface of the medical metal through electrostatic adsorption, covalent crosslinking is also formed among the particles, and the stability of the coating is enhanced. The coating prepared by using the method has the function of controlling adsorption and release of the growth factors and the antibiotics under the normal physiological environment, the activity of the growth factors are keep well and a strong bone induction function is achieved; and in addition, the antibiotics can be slowly released for a long time, and a good antibiosis effect is achieved.
Owner:SOUTHWEST JIAOTONG UNIV
Prepn process of titanium sintering porous titanium artificial bone with bioceramic coating
InactiveCN101020084AGood biological activityHigh mechanical strengthSurgeryProsthesisTitanium metalSol-gel
The preparation process of sintered porous titanium artificial bone with bioceramic coating belongs to the field of biomedicine engineering technology. The preparation process includes stereo weaving of titanium metal fiber to form bionic structure model simulating human body's bone trabecula, pre-pressing formation and vacuum sintering to prepare porous titanium artificial bone, sol-gel process to form gradient and composite coating on the surface of the porous titanium artificial bone. The present invention can protect titanium metal skeleton, avoid titanium ion dissociation and make the artificial bone possess biological characteristic, and may be used in the clinical repair of large bone defect.
Owner:SHANGHAI JIAO TONG UNIV
Method of preparing simvastatin sustained-release microsphere carried series
InactiveCN101219119ARelease stabilityLarge adjustment rangeOrganic active ingredientsSurgeryMicrospherePolyvinyl alcohol
The invention relates to a method that a functional drug is enveloped into a polymeric material with biodegradability to form a nano-micron microsphere system. The method comprises that the polymeric material and simvastatin are dissolved in an organic liquor to form uniform dispersion which is then added into an liquor containing emulsifier Tween 80 and biologically nontoxic electrolytic polyvinyl alcohol or sodium dodecyl benzene sulfonate (SDBS), and then the obtained liquor is stirred, evaporated at a reduced pressure, centrifugalized, washed and vacuum dried, finally the simvastatin-contained delayed-release microsphere system is obtained. The surface of the microsphere is smooth and round, the granule thereof is regular without conglutination, and the granule diameter, the drug-loading rate (1-10 percent) and the encapsulation rate (above 40 percent) are all controllable, and the delayed-release time exceeds 2 months. The prepared simvastatin-contained delayed-release microsphere system can be processed into various preparations used in bony tissue absorption or bony defect parts, the microsphere system is degraded at a proper speed, thus the simvastatin can be further released; the degradation of the polymer can provide bony tissue with subsequent recuperating space to complete the repair of the bony defect parts.
Owner:JILIN UNIV
Method for preparing medical porous titanium-tantalum artificial bone and artificial joint, and products thereof
ActiveCN106693069AGuaranteed bonding qualityReliable workmanshipPharmaceutical delivery mechanismTissue regenerationBiocompatibility TestingArtificial bone
The invention discloses a method for preparing porous titanium-tantalum artificial bone and joint and products thereof, and belongs to the field of biological materials. The method comprises the following steps: S1, grinding to-be-bonded surfaces of a titanium alloy sheet and a tantalum sheet, and performing ultrasonic washing sequentially with acetone, alcohol and deionized water; S2, fitting the titanium alloy sheet and the tantalum sheet, heating to 850-1050 DEG C, insulating for 20-40 minutes, pressurizing to perform plastic deformation, and air-cooling to room temperature to form metallurgic bonding between the two materials; S3, quickly preparing pores having a pore size of 300-600mu m in a compound plate by utilizing a solid laser; S4, preparing various artificial bones and joints from the titanium-tantalum compound plate by utilizing a thermal forming technology; and S5, performing alkali and pre-calcifying treatment to improve the biocompatibility of the compound material. Compared with a traditional explosive compound method, the hot-rolling compound method is safer, controllable, convenient and firm in bonding. The product has relatively high biocompatibility.
Owner:HUAZHONG UNIV OF SCI & TECH
Preparation method of silk fibroin material of composite nano-grade hydroxyapatite and application of silk fibroin material in repairing bone fracture parts
PendingCN108159501AGood biocompatibilityGood mechanical propertiesPharmaceutical delivery mechanismTissue regenerationApatiteInternal fixation
The invention discloses a preparation method of a silk fibroin material of composite nano-grade hydroxyapatite and application of the silk fibroin material in repairing bone fracture parts. The preparation method comprises the following steps: uniformly dispersing nano-grade hydroxyapatite into silk fibroin in a certain ratio, dissolving the nano-grade hydroxyapatite with hexafluoroisopropanol, pouring a mixed solution into a columnar mold, soaking with methanol, performing self-assembling regeneration on a silk fibroin molecular chain so as to obtain a composite material which is excellent inmechanical strength, and finally manufacturing medicinal bone nails from the composite material by using a mechanical processing method. According to the characteristics that the material is good inbiocompatibility, excellent in mechanical property and good in in-vivo degradation controllability, the silk fibroin material can be applied to bone fracture fixation. A silk fibroin / nano-grade hydroxyapatite composite bone fracture internal fixation material with in-vivo degradation controllability can be prepared by using a method which is simple and feasible, high in finished product rate and free of toxicity, osteoporosis symptoms caused in the bone fracture repairing process can be effectively avoided, and because of the characteristic that the material does not need to be taken out through a second time of operation, bone fracture patients can be relieved from pain.
Owner:HUBEI SAILUO BIOLOGICAL MATERIAL CO LTD
Beta-tricalcium phosphate porous ceramic drug-loading stent and preparation method and application thereof
InactiveCN110090323AGood biocompatibilityReduce and avoid inflammationAdditive manufacturing apparatusTissue regenerationWater bathsFreeze-drying
Owner:WUHAN UNIV OF TECH
Implant with surface active coating
InactiveCN108144125AGood biocompatibilityIncrease free energyDental implantsSurface reaction electrolytic coatingBiomedical engineeringInitial stability
The invention discloses an implant with a surface active coating. Screw threads are arranged on an outer side wall of the implant, and are sequentially divided into a cortical bone decompression screwthread section, a cortical bone cutting screw thread section, a cancellous bone extruding screw thread section and a cancellous bone cutting screw thread section from top to bottom; screw pitches ofthe screw threads are increased from top to bottom; a self-tapping groove is formed in the cancellous bone cutting screw thread section; a screw thread is arranged in the implant; a titanium-based bottom layer is arranged on the surface of the implant; a titanium dioxide layer containing calcium phosphate is covered on the outer surface of the titanium-based bottom layer; a polyelectrolyte layer is covered on the outer surface of the titanium dioxide layer containing the calcium phosphate. According to the implant with the surface active coating provided by the invention, the implant is provided with the four different screw threads so as to produce different lateral pressures on a cortical bone and a cancellous bone when screwing into a jaw bone, so that the initial stability of the implant is facilitated, the superior initial stability is favorable for osseointegration, and the surface of the implant is endowed with a favorable antibacterial property through polylysine bacteriostasis.
Owner:DALIAN SANSHENG SCI & TECH DEV
Porous cross pin for operational internal fixation of anterior cruciate ligament for tissue engineering
The invention discloses a degradable and resorbable porous magnesium compound biological factor cross pin for tissue engineering. The cross pin comprises a body which is cylindrical or rhombic magnesium alloy (1), part of the body (1) is provided with a plurality of porous regions used for containing biological factors with bone growth promoting or tendon differentiation effect, one end of the body is sharp and beneficial to cross transplantation of tendons in operation, and a host material of the body is magnesium or magnesium alloy and is subjected to surface modification. The cross pin can improve integration capability between the transplanted tendon and a bone tunnel to stimulate bone growth or induce bone mesenchymal stem cells (BMSC) in the bone tunnel to form tendon differentiation, and the process of tendon-bone healing is accelerated.
Owner:张强 +1
Method for preparing polypeptide-grafted chitosan/hydroxyapatite/pearl powder bracket
The invention relates to a method for preparing a polypeptide-grafted chitosan / hydroxyapatite / pearl powder bracket and belongs to the technical field of medical materials. The method comprises the following steps: firstly, dissolving chitosan into an acetic acid aqueous solution, dissolving 2-imino sulfane hydrochloride into the acetic acid aqueous solution, adjusting pH value, dialyzing and freeze-drying to obtain sulfhydrylated chitosan; dissolving bone morphogenetic protein-2 polypeptide into dimethyl sulfoxide, and adding into a sulfhydrylated chitosan aqueous solution to obtain polypeptide-grafted chitosan; at last, dissolving polypeptide-grafted chitosan into hydrochloric acid, adding pearl powder and hydroxyapatite powder, filling into a cylindrical mould, freeze-drying to obtain the polypeptide-grafted chitosan / hydroxyapatite / pearl powder bracket. The method has the advantages that BMP-2 polypeptide is grafted onto the chitosan through a chemical method. The bracket material has good osteoconduction, degradability and cell adhesion, meanwhile has osteoinduction as existence of the polypeptide and pearl powder organic matrix, and can be applied to bone defect repairing.
Owner:TSINGHUA UNIV +1
Method for preparing bone grafting material with pilose antler and deer bone as material and the bone grafting material prepared by the method
The present invention discloses a method for preparing bone grafting material by using velvet deerhorn and deer's bone as raw material and bone grafting material prepared by adopting said preparation method. It is characterized by that said invention utilizes the extract of velvet deerhorn and deer's cancellous bone to prepare bone-grafting material, its resource is rich and its application is safe, and said bone-grafting material contains several growth factors and velvet deerhorn polypeptide, so that it has obvious bone induction action, and can obtain extensive application.
Owner:王喜文
Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold
InactiveCN106693061AImprove biological activityOsteoinductiveProsthesisSelective laser sinteringBiological property
The invention belongs to the technical field of composite bone scaffold preparation and provides a selective laser sintering preparation method by the utilization of nanometer 1393 bioglass and nano-diamond reinforced polyvinylidene fluoride. By the short degradation period of the 1393 bioglass, degradation of a polyvinylidene fluoride scaffold is promoted and the degradation speed is accelerated. By the high hardness and low granularity of nano-diamond, hardness and rigidity of the polyvinylidene fluoride scaffold are enhanced. Meanwhile, by excellent biological properties, bone inductivity of the polyvinylidene fluoride scaffold is enhanced. By the method, the nano-composite bone scaffold with good biological properties, controllable degradability and good mechanical property is prepared. The product is low-cost, has strong practicality, and has strong promotion and practical value.
Owner:CENT SOUTH UNIV
Biocompatible composite bone repair material
The invention discloses a biocompatible composite bone repair material which is characterized by being prepared from the following raw materials in parts by weight: 15-20 parts of demineralized bone matrixes, 4-6 parts of hydroxyapatite, 6-8 parts of silk protein powder, 8-12 parts of shell powder, 3-5 parts of synthetic fiber, 1.2-1.5 parts of chitosan, 10-15 parts of bone morphogenetic proteins, 12-15 parts of a collagen solution and 10-12 parts of nanometer polylactic acid. The bone morphogenetic proteins in the biocompatible composite bone repair material can be used for inducing undifferentiated cells at the periphery of blood vessels to be converted to bones and cartilages so as to have a bone inducing effect; due to the addition of polylactic acid and other components with relatively good biocompatibility, bone cells can form new bones through surface creepage, and the long-term tensile strength can be kept; and due to the addition of hydroxyapatite, acidic products generated by polylactic acid degradation can be neutralized, the irritation effects of overhigh acidic products can be eliminated, and mineral substances can be provided for the growth of bone tissues.
Owner:刘泽华
ZIF-8 drug-loaded hydrogel osteogenesis-promoting scaffold, preparation method and application
ActiveCN113679891AReduce formationImprove hydrophilicityPharmaceutical delivery mechanismTissue regenerationBone tissueMetal-organic framework
The invention belongs to the technical field of metal-organic frameworks, and discloses a ZIF-8 drug-loaded hydrogel osteogenesis-promoting scaffold, a preparation method and application, and the preparation method of the ZIF-8 drug-loaded hydrogel osteogenesis-promoting scaffold comprises the steps of construction of an SIM-ZIF-8 drug-loaded system and construction of the SIM-ZIF-8 / PEGDA / SA hydrogel. The novel ZIF-8 drug-loaded hydrogel osteogenesis-promoting scaffold is SIM-ZIF-8 / PEGDA / SA. According to the invention, an in-situ synthesis method is adopted to load SIM in a ZIF-8 pore structure (SIM-ZIF-8), and the biochemical microenvironment of bone tissues is improved, so that the dual effects of lowering lipid and forming bones are achieved. According to the invention, the ZIF-8 is loaded with an SIM small molecule drug for the first time, and the finally formed SIM-ZIF-8 system can reduce fat formation and promote osteogenesis under a high fat condition, and has a good application prospect in treatment of bone metabolic diseases caused by hyperlipidemia.
Owner:SICHUAN UNIV
A kind of bone implant filling material and preparation method thereof
ActiveCN103800944BFast degradationControl to adjust release speedPeptide/protein ingredientsProsthesisBiocompatibility TestingSlow Release Formulation
The invention provides a bone-grafting filling material and a preparation method thereof. The method comprises the following steps: mixing and crushing biphasic calcium phosphates, calcium sulphate and iron oxide into grains of 0.1-1mm, burning at 800 DEG C for 3 hours, taking out to soak in 1M of (NH4)2HPO4 solution for 24 hours; drying two days, and burning at the temperature of 1100 DEG C for 1-2 days; slowly cooling, rinsing and baking, so as to obtain a skeleton structure; spraying a slow release formulation on a layer of collagen surface; spraying a layer of collagen on the surface of the slow release formulation to obtain a compound protein layer; baking the composite protein layer at 30 DEG C, carrying out superfine grinding, so as to obtain protein particles which are 50-100nm in particle size; finally, adding the skeleton structure and the protein particles to absolute ethyl alcohol; placing under the conditions at 1-5 DEG C and -0.01 to -0.05MPa for 2-3 days, so as to obtain the bone-grafting filling material. The bone-grafting filling material disclosed by the invention has biodegradability and biocompatibility, is free of or low in immunogenicity, strong in bone conductibility, bone inductivity, mechanical tolerance and the like, and kinds of performance requirements required by the bone filling material are completely met.
Owner:徐州博创建设发展集团有限公司
High-magnesium microenvironment bone marrow stem cell microsphere carrier as well as preparation method and application thereof
ActiveCN111195370AGood osteoinductive effectHave a proliferative effectTissue regenerationMicrocapsulesMicrosphereBiochemistry
The invention provides a high-magnesium microenvironment bone marrow stem cell microsphere carrier as well as a preparation method and an application thereof, magnesium ions are compounded into the microsphere carrier to form a local high-magnesium environment, the size of the microsphere carrier is within 500 [mu]m, and the concentration of the magnesium ions is 2.5 mM to 10 mM. According to theconcept and the preparation method for constructing the stem cell microsphere carrier of the local high-magnesium microenvironment, on one hand, when the magnesium ion concentration is screened out tobe 2.5 mM to 5mM, the osteogenesis induction effect is optimal; secondly, the diameter of the prepared stem cell microsphere carrier is within 500 microns, so that the loading rate and survival rateof stem cells are effectively increased, osteogenic differentiation of the loaded stem cells is promoted by utilizing a local high-magnesium environment, and the defects of high cost, difficulty in slow release and the like caused by using protein factors are reduced; finally, when the prepared high-magnesium microenvironment stem cell microsphere carrier is used for bone defect regeneration and repair, newly born bones in a defect area are obviously increased, and the repair effect is remarkably improved.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
A magnesium phosphate bone cement
ActiveCN105731846BGood biocompatibilityFacilitate Outward ResponseSurgical adhesivesTissue regenerationMagnesium phosphateMagnesium orthophosphate
Owner:NINGBO HICREN BIOTECH
Biologically cmposite artificial bone and its preparing process
InactiveCN1158109COsteoinductiveHas bone conductionUnknown materialsSynthetic polymeric active ingredientsApatiteSolvent
Owner:赵建华 +2
Injection aquagel of sodium alginate cross-linking gelatin comprising biphase calcium phosphor granule, method for making same and use thereof
InactiveCN100408112CGood biocompatibilityFacilitated DiffusionProsthesisCross-linkCalcium phosphorus
The invention relates to an ejected aquagel of sodium alginate crosslink dope, with dual-phase calcium-phosphorus particle, wherein it is prepard from aldehyde group sodium alginate, dope, and dual-phase calcium-phosphorus particles; the mass percentages of each material are: aldehyde group sodium alginate at 5-20%; dope at 10-30%; and dual-phase calcium-phosphorus particles at 50-70%. The invention also discloses a relative preparation and application, wherein said inventive product is characterized in that: (1), the materials are safe and innocuous; (2), it can provide best physical chemical environment for regenerating and rebuilding skelton, with better biological compatibility and adjustable physical property and biological degrade function; (3), the material can stuff the skeleton damage in any shape, to contact the around organism, with simple operation.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
A kind of bone tissue replacement material and its preparation method
ActiveCN108578766BMeet the requirements for replacement materialsHigh mechanical strengthPharmaceutical delivery mechanismTissue regenerationPorosityBone tissue
Owner:SICHUAN UNIV
Drug sustained-release hydrogel semi-embedded composite scaffold and preparation method thereof
ActiveCN112386744AImprove bindingStable structureTissue regenerationProsthesisPharmaceutical drugComposite scaffold
The invention relates to the technical field of biomedical materials, in particular to a drug sustained-release hydrogel semi-embedded composite scaffold and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing an alendronate sodium deposition type hydroxyapatite scaffold; (2) preparing a pre-crosslinked drug sustained-release hydrogel solution; (3)sealing the holes in the lower layer of the hydroxyapatite scaffold with gelatin; (4) injecting the pre-crosslinked drug sustained-release hydrogel solution obtained in the step (2) into the upper layer of the hydroxyapatite scaffold, and carrying out photo-crosslinking; and (5) cleaning the hydrogel semi-embedded composite scaffold, and dissolving and removing the gelatin for sealing the holes in the lower layer of the scaffold to obtain the drug sustained-release hydrogel semi-embedded composite scaffold. The preparation method is convenient to operate and control, high in production efficiency, stable in product quality and beneficial to industrial production, and the prepared composite scaffold has the advantages of bionic structure, mechanical matching, high biological activity and capability of promoting targeted differentiation of stem cells.
Owner:THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Preparation method and product of medical porous titanium-tantalum artificial bone and artificial joint
ActiveCN106693069BGuaranteed bonding qualityReliable workmanshipPharmaceutical delivery mechanismTissue regenerationBiocompatibility TestingArtificial bone
The invention discloses a method for preparing porous titanium-tantalum artificial bone and joint and products thereof, and belongs to the field of biological materials. The method comprises the following steps: S1, grinding to-be-bonded surfaces of a titanium alloy sheet and a tantalum sheet, and performing ultrasonic washing sequentially with acetone, alcohol and deionized water; S2, fitting the titanium alloy sheet and the tantalum sheet, heating to 850-1050 DEG C, insulating for 20-40 minutes, pressurizing to perform plastic deformation, and air-cooling to room temperature to form metallurgic bonding between the two materials; S3, quickly preparing pores having a pore size of 300-600mu m in a compound plate by utilizing a solid laser; S4, preparing various artificial bones and joints from the titanium-tantalum compound plate by utilizing a thermal forming technology; and S5, performing alkali and pre-calcifying treatment to improve the biocompatibility of the compound material. Compared with a traditional explosive compound method, the hot-rolling compound method is safer, controllable, convenient and firm in bonding. The product has relatively high biocompatibility.
Owner:HUAZHONG UNIV OF SCI & TECH
A kind of preparation method of peptide chitosan/hydroxyapatite/pearl powder scaffold
The invention relates to a preparation method of a scaffold connected with polypeptide chitosan / hydroxyapatite / pearl powder, which belongs to the technical field of medical materials. First, chitosan was dissolved in acetic acid aqueous solution, and then 2-iminosulfane hydrochloride was dissolved in it, the pH value was adjusted, dialyzed, and freeze-dried to obtain thiolated chitosan; bone morphogenetic protein-2 polypeptide Dissolved in dimethyl sulfoxide, added to the aqueous solution of thiolated chitosan to obtain the peptide chitosan; finally dissolved the peptide chitosan in hydrochloric acid, added pearl powder and hydroxyapatite powder, filled Put it in a cylindrical mold and freeze-dry to obtain a polypeptide-chitosan / hydroxyapatite / pearl powder scaffold. The advantage of the method of the present invention is that the BMP-2 polypeptide is grafted onto the chitosan through a chemical method. In addition to good osteoconductivity, degradability, and cell adhesion, the scaffold material also has osteogenic induction due to the presence of polypeptide and pearl powder organic matrix, and can be used for bone defect repair.
Owner:TSINGHUA UNIV +1
Preparation method of silk fibroin composite bioglass tissue repair material
InactiveCN107137778AGood biocompatibilityImprove tissue repair abilityConjugated cellulose/protein artificial filamentsFilament/thread formingTissue repairElectrospinning
The invention relates to a preparation method of silk fibroin composite bioglass tissue repair material and belongs to the field of biomedical materials. The preparation method includes preparation of silk fibroin solution, preparation of bioglass solution, and preparation of repair material by electrospinning. Silk fibroin can improve the mechanical properties of the material, bioglass can improve the medical properties of the material. The tissue repair material prepared has good mechanical properties, tissue repair properties and drug adhesion properties.
Owner:HEFEI CHUANGWO TECH CO LTD
A preparation method of medical pure magnesium surface coupling loaded bone growth-inducing traditional Chinese medicine coating
InactiveCN106521603BCorrosion resistanceGood biocompatibilityAnodisationPharmaceutical delivery mechanismHemolysisMicro arc oxidation
A preparation method of medical pure magnesium surface coupling load inducing bone growth traditional Chinese medicine coating relates to a preparation method of medical pure magnesium surface coating. According to the preparation method provided by the invention, a series of biological problems, such as hemolysis, inflammation and the like, caused by the fact that the existing medical magnesium and magnesium alloy materials are degraded quickly in the physiological environment, and the technical problems that potential hazard is generated on tissue growth and repair are solved. The preparation method comprises the steps: 1, performing surface pretreatment on a pure magnesium test sample; 2, preparing micro-arc oxidation electrolyte; 3, performing ultrasonic micro-arc oxidation treatment; and 4, performing aftertreatment. The coating composite material prepared by the method is formed by compounding pure magnesium and coupling modifying self-assembling traditional Chinese medicine coating on the surface of the pure magnesium, and has the characteristics of metal materials and ceramic materials; an ultrasonic-micro-arc oxidation composition technology and a self-assembling technology of the preparation method are green environmentally-friendly processes, so low production cost can be guaranteed well; furthermore, the prepared material has excellent bone inducing property, corrosion resistance and antibacterial property.
Owner:JIAMUSI UNIVERSITY
Bone tissue replacement material and preparation method thereof
ActiveCN108578766AMeet the requirements for replacement materialsHigh mechanical strengthPharmaceutical delivery mechanismTissue regenerationPorosityBone tissue
The invention belongs to the field of bone tissue replacement materials and particularly relates to a preparation method of adopting a chitosan-graphene-hydroxyapatite compound material as a bone tissue replacement material. The preparation method of the bone tissue replacement material includes the steps of preparing a hydroxyapatite / chitosan sizing agent, preparing a melamine sponge carrying thehydroxyapatite / chitosan sizing agent, conducting sintering molding, and conducting reduction of loaded graphene oxide and graphene oxide. A preparation method of the melamine sponge carrying the hydroxyapatite / chitosan sizing agent includes the steps of soaking the melamine sponge in the hydroxyapatite / chitosan sizing agent, extruding the melamine sponge to make pores in the melamine sponge filled with the sizing agent, and then taking the melamine sponge out for vacuum drying to obtain the melamine sponge carrying nano-hydroxyapatite / chitosan, wherein the vacuum temperature is 40-80 DEG C, and the vacuum degree is 60-90 KPa. The bone tissue replacement material is of a porous structure, has high mechanical intensity and high porosity and can meet the requirements of the bone tissue replacement material.
Owner:SICHUAN UNIV
A kind of yttrium-containing amorphous magnesium alloy material and preparation method thereof
ActiveCN106636980BImprove corrosion resistanceNo corrosion degradationBiocompatibility TestingYttrium
The invention discloses a yttrium-containing amorphous alloy material and a preparation method thereof. The alloy is characterized in that: the alloy structure is amorphous, and is composed of the following components by mass percent: 0.3‑6% Y, 0.5‑6% Y 2% Zn, 0.5-2% Ca, the balance is magnesium and impurity elements introduced during the preparation process in a small amount. Compared with the prior art, the yttrium-containing amorphous magnesium alloy material of the present invention has the advantages that (1) it has superior corrosion resistance, and its corrosion resistance is even 4 times that of some existing magnesium alloys, and can be used in orthopedics The growth recovery cycle provides effective stress support without destructive corrosion degradation; (2) has superior mechanical properties; (3) not only has good biocompatibility, but also has osteoinductivity, which can make the fracture growth recovery cycle shorten.
Owner:JILIN UNIV
Bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and preparation method
The invention discloses a bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and a preparation method. The bracket material mainly consists of strontium polyphosphate and calcium polyphosphate according to mol ratio of strontium and calcium of 0.5-10% and is in a porous block structure. The preparation method comprises the following steps of: proportioning the strontium polyphosphate and calcium polyphosphate according to the mol ratio of strontium and calcium determined by the bracket material of bone tissue engineering, adding 30-50% of a cavity-inducing agent based on the proportional weight of the strontium polyphosphate and calcium polyphosphate, preparing blocks with designed shapes after adequately mixing; sintering for1-3 hours at 820-950 DEG C, and cooling along with the sintering device to environmental temperature, thus, the bracket material having the self-promoting vascularizing function is obtained. The bracket material of the bone tissue engineering disclosed by the invention has favorable self-promoting vascularizing function, good biodegradability, bone conductivity, bone inductivity and biocompatibility, and is reliable for repairing and treating the bone for bone defect patients.
Owner:SICHUAN UNIV
Preparation method of chitin composite bio-glass tissue repair material
InactiveCN107158469AGood biocompatibilityHas the function of tissue repairTissue regenerationProsthesisTissue repairElectrospinning
The invention discloses a preparation method of a chitin composite bio-glass tissue repair material and belongs to the field of biological medicine materials. The method comprises the steps of preparation of a chitin solution, preparation of a bioglass solution and electrostatic spinning to prepare a repair material. The chitin is capable of improving the mechanical property of the material and has antibacterial property; and the bioglass is capable of improving the medical property of the material. The prepared tissue repair material has good mechanical property, tissue repair performance and drug adhesiveness.
Owner:HEFEI CHUANGWO TECH CO LTD
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