A magnesium phosphate bone cement

Abstract

The invention relates to a magnesium phosphate bone cement. The bone cement includes a powder and a liquid. The liquid-solid ratio of the liquid to the powder is 0.1-0.5ml / g. The powder is composed of the following components: 32-70wt % phosphate, 28-65wt% magnesium oxide and 1-15wt% silicon-containing compound; preferably, the powder also includes ammonium dihydrogen phosphate and degradable adhesion-promoting material, and the ammonium dihydrogen phosphate accounts for phosphate 5‑30% by weight of the total amount. During the degradation process, the bone cement of the present invention will produce a porous gel layer rich in Si-O-Si, which can enhance protein adsorption, promote extracellular response, reduce the freeness of metal ions, thereby improving the bioactivity of bone cement. compatibility. The bone cement of the invention also has early high strength and excellent bonding performance, and can be used for bone bonding, reinforced screw fixation and the like in addition to traditional bone filling.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a magnesium phosphate bone cement. Background technique [0002] According to the report of the Ministry of Civil Affairs, there are nearly 3 million bone defects and bone injuries in my country every year, and there is a huge demand for bone repair materials. At present, bone repair materials clinically used in the field of orthopedics mainly include biomedical materials such as calcium sulfate, calcium phosphate, and polymethyl methacrylate (PMMA). [0003] Although calcium phosphate has good biocompatibility and biological activity, it degrades very slowly in the body due to the high ratio of calcium to phosphorus. For example, Chinese patent 200810092798.1 discloses a calcium phosphate-based bone cement with good biocompatibility, but slow degradation rate and poor adhesion. [0004] In recent years, there have been many studies on calcium phosphate-based composite bioma...

AI Technical Summary

Problems solved by technology

Chinese patent 201010534490.5 discloses an injectable degradable calcium sulfate and calcium phosphate composite material, which has good osteoconductivity and biocompatibility, but has disadvantages such as poor adhesion

[0007] There are still some problems in the actual application of the existing bone cement: 1. When the material is developed as a bone adhesive, how to ensure the stability of the connection, still lags behind the normal healing speed of the fracture, and hinders the healing of the fracture effect

Judging from the existing research results, these materials still have a certain degree of inflammatory response, which has an adverse effect on tissue healing.

For example, the degradation of potassium salt type MPC in the body will cause the abnormal increase of potassium and magnesium ions in the local body fluid and the alkalinization caused by the increase of pH; adversely affect tissue healing

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