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Injection aquagel of sodium alginate cross-linking gelatin comprising biphase calcium phosphor granule, method for making same and use thereof

A technology of sodium alginate and cross-linked gelatin, which is applied in the field of medical devices, can solve problems such as weak strength, high price, and poor shape-forming ability, and achieve improved mechanical properties, excellent biocompatibility, and adjustable physical and mechanical properties Effect

Inactive Publication Date: 2008-08-06
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Collagen has been used as a scaffold material for bone tissue engineering for a long time. Its advantages are: good biocompatibility, the amino acids that make up collagen are easily recognized by cell receptors, and are easily hydrolyzed by collagenase in vivo, which can be used for bone regeneration and Reconstruction provides a physical scaffold and an optimal chemical environment; disadvantages: weaker strength, poor formability, expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Disperse 50.00 g of sodium alginate in 250 ml of absolute ethanol to form a suspension (I), and dissolve 21.50 g of sodium periodate in 250 ml of water to form a solution (II). (II) was added to (I), and after stirring for 6 hours at room temperature on a magnetic stirrer in the dark, 2 parts of 5ml reaction solution were taken out to analyze the degree of oxidation. Immediately add 5.64mL of ethylene glycol to the remaining reaction solution, and stir for 15min in the dark, then slowly pour into 500mL of anhydrous ethanol that is being stirred vigorously to precipitate sodium alginate, filter, and dry the obtained precipitate at 40°C for 12h in a vacuum, then Dissolve in distilled water (concentration: 200g / L), let stand at 4°C for 1h, filter, and dialyze the filtrate until the NaIO in the dialysis medium cannot be detected by the UV spectrophotometer 4 in the presence of (λ=223nm), lyophilized. The degree of oxidation for this reaction was 39.77%.

[0036] Add 1.00 ...

Embodiment 2

[0038] Disperse 50.00 g of sodium alginate in 250 ml of absolute ethanol to form a suspension (I), and dissolve 32.40 g of sodium periodate in 250 ml of water to form a solution (II). (II) was added to (I), and after stirring for 6 hours at room temperature on a magnetic stirrer in the dark, 2 parts of 5ml reaction solution were taken out to analyze the degree of oxidation. Immediately add 8.47mL of ethylene glycol to the remaining reaction solution, and stir for 15min in the dark, then slowly pour into 500mL of anhydrous ethanol which is being stirred vigorously to precipitate sodium alginate, filter, and dry the obtained precipitate in vacuum at 40°C for 12h, then Dissolve in distilled water (concentration: 200g / L), let stand at 4°C for 1h, filter, and dialyze the filtrate until the NaIO in the dialysis medium cannot be detected by the UV spectrophotometer 4 in the presence of (λ=223nm), lyophilized. The degree of oxidation for this reaction was 58.82%.

[0039] Add 1.00 g...

Embodiment 3

[0041] Disperse 50.00 g of sodium alginate in 250 ml of absolute ethanol to form a suspension (I), and dissolve 43.20 g of sodium periodate in 250 ml of water to form a solution (II). (II) was added to (I), and after stirring for 6 hours at room temperature on a magnetic stirrer in the dark, 2 parts of 5ml reaction solution were taken out to analyze the degree of oxidation. Immediately add 11.28mL of ethylene glycol to the remaining reaction liquid, and stir for 15min in the dark, then slowly pour into 500mL of anhydrous ethanol which is being stirred vigorously to precipitate sodium alginate, filter, and dry the obtained precipitate at 40°C for 12h in vacuum, then Dissolve in distilled water (concentration: 200g / L), let stand at 4°C for 1h, filter, and dialyze the filtrate until the NaIO in the dialysis medium cannot be detected by the UV spectrophotometer 4 in the presence of (λ=223nm), lyophilized. The degree of oxidation for this reaction was 79.20%.

[0042] Add 1.00 g ...

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PUM

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Abstract

The invention relates to an ejected aquagel of sodium alginate crosslink dope, with dual-phase calcium-phosphorus particle, wherein it is prepard from aldehyde group sodium alginate, dope, and dual-phase calcium-phosphorus particles; the mass percentages of each material are: aldehyde group sodium alginate at 5-20%; dope at 10-30%; and dual-phase calcium-phosphorus particles at 50-70%. The invention also discloses a relative preparation and application, wherein said inventive product is characterized in that: (1), the materials are safe and innocuous; (2), it can provide best physical chemical environment for regenerating and rebuilding skelton, with better biological compatibility and adjustable physical property and biological degrade function; (3), the material can stuff the skeleton damage in any shape, to contact the around organism, with simple operation.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an injectable hydrogel material containing an inorganic / organic phase, and at the same time, the invention also relates to a preparation method and application of the hydrogel material. Background technique [0002] Bone defect or bone deficiency is a disease of the skeletal system with a high prevalence rate, a serious threat to human health, and a reduction in the patient's quality of life (which can lead to disability). It can be caused by various diseases such as tumors, trauma, severe infection, and congenital malformations. According to the statistics of the World Health Organization (WHO): half of the chronic diseases in the crowd over the age of 65 are bone-related; as the fractures caused by osteoporosis double, nearly 40% of women over the age of 50 will be affected. In the United States, approximately 6.5 million fractures occur each year, and approximately 2.2 million r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/52
Inventor 王琴梅
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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