Bone tissue replacement material and preparation method thereof

A technology for replacing materials and bone tissue, used in tissue regeneration, pharmaceutical formulations, medical science and other directions, can solve the problems of complex preparation process, high production cost, low porosity, etc., to achieve easy removal, high open porosity, high The effect of mechanical strength

Active Publication Date: 2018-09-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many technologies and methods that can be used to prepare bone tissue engineering scaffolds, such as: electrospinning, phase separation / freeze drying, solvent casting / particle leaching technology, rapid prototyping technology and gas foaming technology to prepare scaffold materials, However, these technologies have the characteristics of complex preparation process, high production cost, low porosity, and poor strength.

Method used

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  • Bone tissue replacement material and preparation method thereof
  • Bone tissue replacement material and preparation method thereof
  • Bone tissue replacement material and preparation method thereof

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preparation example Construction

[0036] The preparation method of the bone tissue replacement material in the present invention can adopt the following steps:

[0037] (1) Preparation of hydroxyapatite / chitosan slurry: disperse the hydroxyapatite powder in the aqueous solution evenly (for example, it can be ultrasonicated for 1 hour), then add acetic acid, add chitosan powder while stirring, and then stir and mix well (Generally need to stir for 2h) to obtain hydroxyapatite / chitosan slurry; wherein, the mass ratio of hydroxyapatite and chitosan is: 20-80 parts by weight of hydroxyapatite, 0.5-4 parts by weight of chitosan ;

[0038] (2) Preparation of melamine sponge loaded with hydroxyapatite / chitosan slurry: immerse the melamine sponge in the hydroxyapatite / chitosan slurry obtained in step (1) and squeeze the melamine sponge The pores in the sponge are filled with the slurry, and then vacuum-dried to obtain a melamine sponge loaded with nano-hydroxyapatite / chitosan, wherein the vacuum temperature is 40-80°...

Embodiment 1

[0044] (1) Preparation of CS / HA slurry: Disperse 3g of HA nano-hydroxyapatite powder in 10ml of aqueous solution, add 200ul of acetic acid after ultrasonication for 1h, add 0.3g of CS powder after magnetic stirring for 10min, and stir for 2h.

[0045] (2) Preparation of melamine sponges of different shapes: Cut the purchased melamine sponges into small cuboids of 0.5cm*0.5cm*1cm with a blade.

[0046] (3) Preparation of melamine sponge loaded with CS / HA slurry: immerse the block-shaped melamine sponge obtained in (2) in the slurry in (1) and suck the slurry into the sponge by squeezing the melamine sponge, Place it in a 60-degree vacuum oven after taking it out and dry it under the condition of a vacuum of 80kPa.

[0047] (4) Sintering molding: Put the dry CS / HA-loaded melamine sponge obtained in (3) into a crucible and sinter it under air conditions. The heating program is to raise the temperature to 330°C at 5°C / min and keep it for 1h Afterwards, the temperature was raised ...

Embodiment 2

[0051] (1) Preparation of CS / HA slurry: Disperse 6g of HA nano-hydroxyapatite powder in 10ml of aqueous solution, add 200ul of acetic acid after ultrasonication for 1h, add 0.3g of CS powder after magnetic stirring for 10min, and stir for 2h.

[0052] (2) Preparation of melamine sponges of different shapes: Cut the purchased melamine sponges into small cuboids of 0.5cm*0.5cm*1cm with a blade.

[0053] (3) Preparation of melamine sponge loaded with CS / HA slurry: immerse the block-shaped melamine sponge obtained in (2) in the slurry in (1) and suck the slurry into the sponge by squeezing the melamine sponge, Place it in a 60-degree vacuum oven after taking it out and dry it under the condition of a vacuum of 80kPa.

[0054] (4) Sintering molding: put the dried CS / HA-loaded melamine sponge obtained in (3) into a crucible and sinter it under the condition of air. After 1h, the temperature was raised to 1200°C at 10°C / min, kept for 2h, and then naturally cooled to room temperature...

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Abstract

The invention belongs to the field of bone tissue replacement materials and particularly relates to a preparation method of adopting a chitosan-graphene-hydroxyapatite compound material as a bone tissue replacement material. The preparation method of the bone tissue replacement material includes the steps of preparing a hydroxyapatite/chitosan sizing agent, preparing a melamine sponge carrying thehydroxyapatite/chitosan sizing agent, conducting sintering molding, and conducting reduction of loaded graphene oxide and graphene oxide. A preparation method of the melamine sponge carrying the hydroxyapatite/chitosan sizing agent includes the steps of soaking the melamine sponge in the hydroxyapatite/chitosan sizing agent, extruding the melamine sponge to make pores in the melamine sponge filled with the sizing agent, and then taking the melamine sponge out for vacuum drying to obtain the melamine sponge carrying nano-hydroxyapatite/chitosan, wherein the vacuum temperature is 40-80 DEG C, and the vacuum degree is 60-90 KPa. The bone tissue replacement material is of a porous structure, has high mechanical intensity and high porosity and can meet the requirements of the bone tissue replacement material.

Description

technical field [0001] The invention belongs to the field of bone tissue replacement materials, in particular to a chitosan (CS)-graphene (G)-hydroxyapatite (HA) ternary composite material used as a bone tissue replacement material and a preparation method thereof. Background technique [0002] Hydroxyapatite (HA) is the main component of inorganic substances in human bone, and has good biocompatibility and biodegradability. At present, almost all commercial artificial bone materials contain hydroxyapatite, which can be sintered at high temperature to obtain high-strength hydroxyapatite ceramic materials. Common hydroxyapatite bioceramics, coral hydroxyapatite, However, they all have disadvantages such as difficulty in shaping, low porosity, insufficient void size, and poor osteoinductive ability. [0003] Chitosan (CS) widely exists in nature. It has good biocompatibility and can be degraded into glucosamine in the body. Glucosamine is neutral or weakly alkaline, does not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/08A61L27/56A61L27/58
CPCA61L27/08A61L27/12A61L27/56A61L27/58A61L2400/12A61L2430/02
Inventor 石小军周凯喻鹏杨伟杨鸣波
Owner SICHUAN UNIV
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