The invention relates to the field of pesticides and fertilizers, in particular to a pesticidal disease protecting and nutrient pesticide fertilizer and application thereof, and a pesticidal disease protecting and nutrient pesticide fertilizer slow release formulation and application thereof. The pesticidal disease protecting and nutrient pesticide fertilizer comprises 0.001 to 12 parts of thiamethoxam, 0.001 to 5 parts of thifluzamide, 20 to 60 parts of effective fertilizer composition, 0.01 to 10 parts of secondary element fertilizer effective composition, 0.001 to 5 parts of trace element fertilizer effective composition, and 0.001 to 1 part of beneficial element fertilizer effective composition in part by mass, wherein the effective fertilizer composition is selected form N, P2O5 and K2O; the secondary element fertilizer effective composition is selected from calcium, magnesium, silicon or sulfur; the trace element fertilizer effective composition is selected from boron, zinc, manganese, molybdenum, iron or copper; the beneficial element fertilizer effective composition is selenium. The pesticide and fertilizer can effectively prevent and cure aphid in wheat field and banded sclerotial blight, can reduce the loss of wheat field caused by insect pest after being applied, and has good yield-increasing effect.