Delayed-release formulation with acetone-extracted product of Gamboge resin
Patent Information
- Application Number
- DE602024005932
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2024-07-22
- Publication Date
- 2026-07-08
- Estimated Expiration
- 2044-07-22
AI Technical Summary
There is a need for a sustained-release formulation containing the acetone-extracted product of gamboge resin for medical applications, as existing formulations do not effectively maintain a constant drug level over an extended period.
A formulation comprising 25.00 wt% to 31.25 wt% of the acetone-extracted gamboge resin as the active pharmaceutical ingredient, combined with sodium lauryl sulfate, hydroxypropyl methylcellulose, microcrystalline cellulose, silicon dioxide, magnesium stearate, lactose, and dextrose, formulated into tablets for sustained release over 12 to 72 hours, with a mean particle size of 10 µm.
The formulation achieves a gradual and sustained release of the acetone-extracted gamboge resin over 24 hours, maintaining effective drug levels in the bloodstream, as demonstrated by in vitro dissolution tests.