Drug sustained-release hydrogel semi-embedded composite scaffold and preparation method thereof

A composite scaffold and hydrogel technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of immune rejection limitation, side effects of clinical therapy, etc., to promote bone growth, great clinical application value, and simple process Effect

Active Publication Date: 2021-02-23
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the application and efficacy of clinical therapy (including drug therapy and surgical transplantation, etc.) are limited due to side effects, immune rejection, etc.

Method used

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  • Drug sustained-release hydrogel semi-embedded composite scaffold and preparation method thereof
  • Drug sustained-release hydrogel semi-embedded composite scaffold and preparation method thereof
  • Drug sustained-release hydrogel semi-embedded composite scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]In this embodiment, a method for preparing a drug sustained-release hydrogel semi-embedded composite stent includes the following steps:

[0042](1) Preparation of Alendronate Sodium (ALN) deposition type hydroxyapatite scaffold;

[0043](2) Preparation of pre-crosslinked drug sustained-release hydrogel solution;

[0044](3) Use gelatin to seal the holes in the lower layer of the hydroxyapatite scaffold;

[0045](4) Inject the pre-crosslinked drug sustained-release hydrogel solution in step (2) on the upper layer of the hydroxyapatite scaffold in step (3) by means of a mold, and cross-link under ultraviolet light;

[0046](5) Wash the hydrogel semi-embedded composite stent formed in step (4), and dissolve and remove the gelatin that seals the holes in the lower layer of the stent to obtain the drug sustained-release hydrogel semi-embedded composite stent.

[0047]Further, in the step (1), the preparation method of the alendronate sodium deposition type hydroxyapatite scaffold includes the follo...

Embodiment 2

[0065]The difference between this example and Example 1 is that the preparation of the alendronate sodium deposition type hydroxyapatite scaffold is as follows: The preparation is as follows: by weight, hydroxyapatite powder and dispersant PAA-NH4 ( The solid content is soluble in water / glycerin (w / w, 7 / 3) and NH is used3·H2O adjust the pH to 9.50 to prepare a mixture, the added concentration of the hydroxyapatite powder is 45% by weight, and the addition amount of the dispersant PAA-NH4 is 1.5% of the mass of the hydroxyapatite powder; put the mixture into a ball mill pot Mid-grind for 12 h, then add hydroxypropyl methyl cellulose and n-octanol to the ball mill to obtain a slurry with appropriate viscosity. A cylindrical hydroxyapatite three-dimensional scaffold with 60% scaffold porosity was obtained by 3D printing technology, and the printed scaffold was sintered at a high temperature of 1110°C for 3 hours. The bracket is printed with a 30° oblique angle, the bracket radius is 6 ...

Embodiment 3

[0068]The difference between this embodiment and Embodiment 1 is:

[0069]In the step (1), the preparation method of the alendronate sodium deposition type hydroxyapatite scaffold includes the following steps: soak the hydroxyapatite three-dimensional scaffold in alendronate sodium (ALN) solution (the The concentration of alendronate sodium solution is 10 μM), taken out for 12 h, and a low-density hydroxyapatite scaffold deposited by alendronate sodium was obtained. The alendronate sodium deposit was observed as fine needles by scanning electron microscope .

[0070]The rest of the content of this embodiment is the same as that of Embodiment 1, and will not be repeated here.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a drug sustained-release hydrogel semi-embedded composite scaffold and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing an alendronate sodium deposition type hydroxyapatite scaffold; (2) preparing a pre-crosslinked drug sustained-release hydrogel solution; (3)sealing the holes in the lower layer of the hydroxyapatite scaffold with gelatin; (4) injecting the pre-crosslinked drug sustained-release hydrogel solution obtained in the step (2) into the upper layer of the hydroxyapatite scaffold, and carrying out photo-crosslinking; and (5) cleaning the hydrogel semi-embedded composite scaffold, and dissolving and removing the gelatin for sealing the holes in the lower layer of the scaffold to obtain the drug sustained-release hydrogel semi-embedded composite scaffold. The preparation method is convenient to operate and control, high in production efficiency, stable in product quality and beneficial to industrial production, and the prepared composite scaffold has the advantages of bionic structure, mechanical matching, high biological activity and capability of promoting targeted differentiation of stem cells.

Description

Technical field[0001]The present invention relates to the field of biomedical materials, and more particularly to a drug sustained release hydrogel semi-embedded composite stent and a preparation method thereof.Background technique[0002]The complex bone joint structure is composed of joint cartilage, calcified cartilage and cartilage bone. The three structures of the three structures affect each other, and the damage or lesions of any party will affect the development of the biological functions of the other, and it is likely to lead to the overall damage of the backbone. Therefore, while repairing the cartilage and cartilage bone when treating a osteoarth disease, it can achieve the purpose of the root cure. In addition, since the chemical composition of cartilage and cartilage, the mechanical properties and cellular differentiation type have great differentials to form a huge problem for osteoarthrosis. Bone joint damage As a common disease seriously plagued human health, and as t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/54A61L27/12A61L27/22A61L27/20A61L27/56
CPCA61L27/52A61L27/54A61L27/12A61L27/227A61L27/20A61L27/56A61L2430/06A61L2300/602A61L2300/216A61L2300/40C08L5/08
Inventor 焦燕王辉闵登梅王怀明黄榕康路婧胡民辉卫应奇
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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