Biocompatible composite bone repair material

Abstract

The invention discloses a biocompatible composite bone repair material which is characterized by being prepared from the following raw materials in parts by weight: 15-20 parts of demineralized bone matrixes, 4-6 parts of hydroxyapatite, 6-8 parts of silk protein powder, 8-12 parts of shell powder, 3-5 parts of synthetic fiber, 1.2-1.5 parts of chitosan, 10-15 parts of bone morphogenetic proteins, 12-15 parts of a collagen solution and 10-12 parts of nanometer polylactic acid. The bone morphogenetic proteins in the biocompatible composite bone repair material can be used for inducing undifferentiated cells at the periphery of blood vessels to be converted to bones and cartilages so as to have a bone inducing effect; due to the addition of polylactic acid and other components with relatively good biocompatibility, bone cells can form new bones through surface creepage, and the long-term tensile strength can be kept; and due to the addition of hydroxyapatite, acidic products generated by polylactic acid degradation can be neutralized, the irritation effects of overhigh acidic products can be eliminated, and mineral substances can be provided for the growth of bone tissues.

Description

technical field [0001] The invention belongs to the technical field of medical bone materials, in particular to a biocompatible composite bone repair material. Background technique [0002] Nano-bone repair materials are a kind of artificially synthesized materials with various excellent physical and chemical properties (self-curing, high mechanical strength, convenient use, etc.) and biological properties (no toxic side effects, absorption and degradation, good biocompatibility , can induce bone cells and blood vessel growth, etc.) new bone repair materials. Nano-bone repair materials developed in recent years mainly include: nano-ceramics (nano-hydroxyapatite and nano-alumina, etc.), nano-polymers (nano-scale polylactic acid, and polyhydroxyacetic acid, etc.), nanocomposites, nano Bionic bone (nano-hydroxyapatite polyamide 66), nano-bone pulp, etc. Nano-bone repair materials have unparalleled biological properties compared to traditional bone repair materials, and ha...

AI Technical Summary

Problems solved by technology

But there are also certain disadvantages, such as the amount of bone harvested is small, additional bone harvested surgical sites are required, the time for anesthesia and surgery is increased, complications are relatively high, and the bone harvested site may have pain for half a year or longer or discomfort

[0005] Calcium phosphate bone cement is a new type of bone repair material. It has good tissue compatibility and is also a good carrier of antibiotics. It can be implanted in infected bone defects to play a continuous anti-infective effect, but its mechanical strength is low and cannot Restorative synthetic substitutes for weight-bearing bone, such as polymethylmethacrylate, polyetheremethone, polysulfone, vulcanized silicone rubber, etc., are non-degradable materials that, although plentiful, can fill bone of various sizes and shapes Defect, and provide the mechanical strength of the reconstruction area, but because the material is not degradable, the defect area cannot regenerate bone through bone reconstruction

Acrylic bone cement can be shaped in time and has good mechanical properties; however, it has poor biocompatibility and lacks osteoconductivity, and the polymerization process will generate heat and cause surrounding bone necrosis, forming fibrous tissue at the bone-cement interface, and It is not conducive to absorption and ingrowth of bone tissue. How to modify it and improve its biocompatibility is the technical problem to be solved by the present invention