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Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold

A polyvinylidene fluoride and nanotechnology, applied in medical science, prosthesis, etc., can solve problems such as poor degradability, insufficient hardness and stiffness, and weak biological activity

Inactive Publication Date: 2017-05-24
CENT SOUTH UNIV
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Problems solved by technology

[0007] The purpose of the present invention is to solve the problems of weak biological activity, poor degradability, insufficient hardness and rigidity of the polyvinylidene fluoride bone scaffold, and compound nano-1393 bioglass and nano-diamond into polyvinylidene fluoride, and prepare it by selective laser sintering A composite bone scaffold with good biological and mechanical properties

Method used

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Embodiment Construction

[0018] The specific implementation manner of the present invention will be further described below in conjunction with an embodiment, but the content of the present invention is not limited thereto.

[0019] 1) Accurately measure 90g of polyvinylidene fluoride, 5g of nano-1993 bioglass, and 5g of nano-diamond for mechanical dispersion.

[0020] 2) Dissolve the composite material dispersed in step 1) in absolute ethanol to form a ternary composite dispersion suspension, first disperse it by ultrasonic for 30 minutes, stir it by a magnetic stirrer for 1 hour, and finally disperse it by ultrasonic for 30 minutes to obtain Mix a homogeneous solution.

[0021] 3) Filter the solution obtained in step 2, dry at 60° C. for 10 hours, and grind the dried composite powder by a ball mill to obtain a uniformly mixed composite powder.

[0022] 4) Fill the uniformly mixed composite powder into the automatic auxiliary powder device of the selective laser sintering machine, and perform laser ...

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Abstract

The invention belongs to the technical field of composite bone scaffold preparation and provides a selective laser sintering preparation method by the utilization of nanometer 1393 bioglass and nano-diamond reinforced polyvinylidene fluoride. By the short degradation period of the 1393 bioglass, degradation of a polyvinylidene fluoride scaffold is promoted and the degradation speed is accelerated. By the high hardness and low granularity of nano-diamond, hardness and rigidity of the polyvinylidene fluoride scaffold are enhanced. Meanwhile, by excellent biological properties, bone inductivity of the polyvinylidene fluoride scaffold is enhanced. By the method, the nano-composite bone scaffold with good biological properties, controllable degradability and good mechanical property is prepared. The product is low-cost, has strong practicality, and has strong promotion and practical value.

Description

[0001] Technical field [0002] The invention relates to a method for improving the biological properties and mechanical properties of polyvinylidene fluoride materials by using nano-1393 biological glass and nano-diamond, and using a selective laser sintering process to prepare a high-performance nano-composite bone scaffold, which belongs to mechanical engineering and tissue engineering. , an interdisciplinary field of life sciences. Background technique [0003] Autologous bone grafting is considered to be the gold standard of bone grafting, but there are defects such as limited materials and easy to cause complications at the donor site. played an important role in. Polyvinylidene fluoride (Polyvinylidene fluoride) is the repeating unit -CH 2 -CF 2 - The polymer material with excellent semi-crystalline properties, referred to as PVDF, is widely used in the field of biomedicine due to its easy processing, good mechanical properties, good thermal stability and biocompatib...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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