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Preparation method of silk fibroin composite bioglass tissue repair material

A technology of biological glass and silk protein, applied in tissue regeneration, cellulose/protein conjugated artificial filament, filament/thread forming, etc., can solve the problems of poor mechanical properties and poor drug adhesion, and achieve improved mechanical properties, Good porosity, the effect of improving the performance of medicine

Inactive Publication Date: 2017-09-08
HEFEI CHUANGWO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, in view of the existence of its amorphous silicon skeleton, bioglass still presents an amorphous form, poor mechanical properties, and poor drug adhesion, and its application in biomedical materials remains to be further developed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of silk protein composite biological glass tissue repair material, comprising the following steps:

[0020] Step 1: Heat 2L of deionized water to boiling, add 4.24g of sodium carbonate and 5g of silkworm raw silk, boil for 30min, wash with deionized water, and after drying, dissolve with 9.3mol / L LiBr solution; wait until completely dissolved Finally, put the solution into a dialysis bag, dialyze with deionized water for 72 hours, centrifuge at 9000r / min for 20 minutes, and repeat twice to obtain a silk protein solution;

[0021] Step 2: Dissolve 5g of polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer in 62g of ethanol solution with a volume concentration of 70%, and after fully stirring, add 6g of ethyl silicate in turn , 0.7g triethyl phosphate, 1.5g Ca(NO 3 ) 2 4H 2 O, 1g0.5M hydrochloric acid solution, get mixed liquor;

[0022] Step 3: Stir the mixed solution at room temperature for 24 hours and then let it stand....

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PUM

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Abstract

The invention relates to a preparation method of silk fibroin composite bioglass tissue repair material and belongs to the field of biomedical materials. The preparation method includes preparation of silk fibroin solution, preparation of bioglass solution, and preparation of repair material by electrospinning. Silk fibroin can improve the mechanical properties of the material, bioglass can improve the medical properties of the material. The tissue repair material prepared has good mechanical properties, tissue repair properties and drug adhesion properties.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a silk protein composite biological glass tissue repair material. Background technique [0002] Since the discovery of bioglass, people have paid more attention to the influence of bioglass components on biological activity. The rise of nanotechnology has made people realize that structure also has an important impact on biological activity, and more attention has been paid to the effect of size effect and microscopic fine structure on the structure and performance of materials. The nano-bioglass and mesoporous bioglass developed and designed from the nano-scale have attracted the attention of scholars at home and abroad. Bioglass can activate cell genes, help to enhance cell proliferation and differentiation, and has osteoinductive and osteoconductive effects. However, in view of the existence of its amorphous silicon skeleton, bioglass s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/22A61L27/18A61L27/02A61L27/00D01D5/00D01F8/02D01F8/16D01F1/10
CPCA61L27/56A61L27/00A61L27/025A61L27/18A61L27/227A61L27/50A61L2430/02D01D5/0015D01F1/10D01F8/02D01F8/16C08L89/00C08L71/02
Inventor 王吉鹏
Owner HEFEI CHUANGWO TECH CO LTD
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