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Preparation method for double-sensitivity cellulose-based aerogel

A cellulose-sensitive technology, applied in the field of preparation of double-sensitive cellulose-based airgel, can solve the problem of low drug loading capacity, and achieve the effect of low raw material price, light weight and simple operation

Active Publication Date: 2019-01-04
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for virgin cellulose, the drug loading capacity is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing a dual-sensitive cellulose-based airgel in this embodiment uses biomass cellulose as a raw material for preparation, including the following steps:

[0021] (0) Pretreatment-preparation of cellulose suspension: soak 200g of paper pulp (bamboo pulp) in water for 1 to 2 hours, and use a mechanical stirrer with a rotating speed of less than 100rpm for 2 to 5 hours; then use an ultrafine grinder at a rotating speed of 1000 to 2000rpm, The gap between the grinding discs is gradually reduced from 2mm to 0μm or even lower, and the pulp is fibrillated by circulating feeding; finally, the dispersion liquid is homogenized for 10 to 30 times by high-pressure homogenization, and then concentrated by rotary evaporation to a certain extent. Cellulose suspension with good stability (pulp concentration is 0.55wt%, bamboo pulp concentration is 0.48wt%);

[0022] (1) Prepare DAC (dialdehyde cellulose): get 100mL 0.55wt% wood pulp cellulose and 1.5g NaIO 4 Stir in ...

Embodiment 2

[0028] The difference between embodiment 2 and embodiment 1 is:

[0029] (1) Take 2 g of the DAC aqueous dispersion in step (1) of Example 1 in a round-bottomed flask filled with 100 ml of deionized water, stir at 100° C. for 2 h, and centrifuge to obtain a DAC aqueous solution with a concentration of 3.2 mg / mL.

[0030] (2)~(3): the DAC aqueous solution that gets 50ml gained and 20mg polymerizable monomer PDMAEMA join in the there-necked flask that fills deionized water, under N 2 Stir well under atmosphere, use 70% HNO 3 Adjust the pH of the solution to <3, add 5 mg CAN to the mixture, continue to stir for 6 hours, and dialyze to obtain the DAC / PDMAEMA copolymer; take 0.1 g of the copolymer obtained above and 0.5 g of PEI (Mw=600) and mix thoroughly, and stir at room temperature After 12 hours, dialyze and adjust the concentration of the suspension to about 0.1% to obtain a DAC / PDMAEMA / PEI copolymer.

[0031] (4) Take 10ml of DAC / PDMAEMA / PEI copolymer homogeneous dispersio...

Embodiment 3

[0034] (1) Get 100mL 0.48wt% bamboo pulp cellulose and 1.75g ​​NaIO 4 Stir in a 250ml Erlenmeyer flask at room temperature in the dark for 48 hours, then centrifuge, wash with deionized water, and dialyze to obtain a 0.35g / g DAC aqueous dispersion;

[0035] (2)~(3): The DAC water dispersion of 1g gained and 50mg polymerizable monomer PDMAEMA join in the there-necked flask that fills deionized water in N 2 Stir well under atmosphere, use 70% HNO3 Adjust the pH of the solution to 1, add 3 mg CAN to the mixture, continue stirring for 12 hours, and dialyze to obtain the DAC / PDMAEMA copolymer. Take 1 g of the above-obtained copolymer and 5.0 g of PEI (Mw=1800) and mix thoroughly, stir at room temperature for 12 hours, then dialyze, and adjust the concentration of the suspension to about 0.1%, to obtain DAC / PDMAEMA / PEI copolymer.

[0036] (4) Take 10ml of DAC / PDMAEMA / PEI copolymer homogeneous dispersion liquid and quickly form it in liquid nitrogen at -196°C, and then put it into a...

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Abstract

The invention discloses a preparation method for double-sensitivity cellulose-based aerogel. Dialdehyde cellulose, a dialdehyde cellulose / dimethylaminoethyl methacrylate copolymer and a dialdehyde cellulose / dimethylaminoethyl methacrylate / polymine copolymer are prepared successively, then freezing drying is conducted, and a product can be obtained; the product is the double-sensitivity cellulose-based aerogel, the accumulated adsorbing capacity of the aerogel reaches 250 mg / g, the accumulated releasing amount of the aerogel in a 0.2%NaCl (pH<3) solution,a 0.05mol / L NaH2PO4 (pH=3-8) solution ora NaOH (pH>8) solution reaches 63-90%, the obtained product has the advantages that the mass is low, the biocompatibility is good, the porosity is high, and the pH / temperature double-sensitivity is high; the product can be taken as a biomedical material, and has a wide application prospect in medicine slow releasing, wound dressing and other aspects.

Description

technical field [0001] The invention belongs to the field of natural polymer materials, and in particular relates to a preparation method of a double-sensitive cellulose-based airgel. Background technique [0002] Traditional pharmaceutical preparations usually have many side effects, including gastrointestinal or renal side effects. Also, most drugs have a short half-life and must be taken in multiple daily doses to maintain therapeutic blood levels. Therefore, targeting drug release, drug action intensity and drug effect duration has become the subject of research in related disciplines. [0003] Currently, some polymers have been developed to achieve sustained release of drugs to increase the duration of drug effect. However, most pharmaceutical formulations such as Pe, PP, and PDMS are chemically synthesized and non-biodegradable. At present, natural polysaccharides or their derivatives have become the first choice for the research of drug-loaded preparations due to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08G81/02C08F251/02C08F220/34
CPCC08F251/02C08G81/024C08J9/28C08J2201/0484C08J2205/026C08J2387/00C08F220/34C08B15/005C08B15/02C08B15/06C08F299/00C08H8/00C08L1/02C08L1/04C08L1/08C08L79/02C08J2301/02C08J2333/14
Inventor 曾宪海闫贵花孙勇唐兴林鹿雷廷宙
Owner XIAMEN UNIV
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