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Bracket with drug temperature-sensitive controlled-release function and application thereof

A temperature-sensitive, functional technology, applied in the field of stents, to achieve the effect of inhibiting proliferation, good temperature sensitivity, and good drug release function

Inactive Publication Date: 2010-10-20
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on stents with good temperature sensitivity and drug controlled release function.

Method used

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  • Bracket with drug temperature-sensitive controlled-release function and application thereof
  • Bracket with drug temperature-sensitive controlled-release function and application thereof
  • Bracket with drug temperature-sensitive controlled-release function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of amphiphilic block copolymer of temperature-sensitive polymer and degradable hydrophobic polymer

[0037] (1) Mix NIPAm and NHMAAm at a ratio of 7mmol:1mmol, dissolve them in 10ml tetrahydrofuran (THF), then add 0.04mmol benzoyl peroxide (BPO) to the solution as initiator, 0.08mmol mercaptoethanol for chain transfer Agent, solution pass N 2 Breathe 20min;

[0038] (2) Then in N 2 Placed in a 70℃ constant temperature water bath under the protection of, and react with electromagnetic stirring for 7 hours;

[0039] (3) After the reaction liquid is cooled, suction filtration to remove impurities;

[0040] (4) 8-10 times the volume of ether is used as a precipitant, and white powder is obtained after repeated dissolution, precipitation, and vacuum drying.

[0041] (5) Copolymerize the prepared methylol acrylamide and N-isopropyl acrylamide with polycaprolactone (PCL) in a ratio of 1:4 (molar ratio), react at 120°C for 24 hours to obtain the desired amphiphilic temper...

Embodiment 2

[0051] 1. Preparation of amphiphilic block copolymer of temperature-sensitive polymer and degradable hydrophobic polymer

[0052] (1) Mix NIPAm and NHMAAm in a ratio of 5mmol:1mmol, dissolve them in 10ml tetrahydrofuran (THF), then add 0.04mmol benzoyl peroxide (BPO) to the solution as the initiator, and 0.10mmol mercaptoethanol for chain transfer Agent, solution pass N 2 Breathe 20min;

[0053] (2) Then in N 2 Placed in a 70℃ constant temperature water bath under the protection of, and react with electromagnetic stirring for 7 hours;

[0054] (3) After the reaction liquid is cooled, suction filtration to remove impurities;

[0055] (4) 8-10 times the volume of ether is used as a precipitant, and white powder is obtained after repeated dissolution, precipitation, and vacuum drying.

[0056] (5) The prepared copolymer and polycaprolactone (PCL) are in a ratio of 1:6 (molar ratio) and reacted at 180°C for 24 hours to obtain the desired amphiphilic temperature-sensitive copolymer P-(NIPAA...

Embodiment 3

[0064] 1. Preparation of amphiphilic block copolymer of temperature-sensitive polymer and degradable hydrophobic polymer

[0065] The specific method is the same as in Example 1, wherein the ratio of poly-N-isopropylacrylamide and polylactide (PLA) is 1:1 (molar ratio).

[0066] 2. Preparation of the coating with temperature-sensitive and controlled-release drug

[0067] Weigh 100 mg of polylactide (PLA) to prepare an organic solution of tetrahydrofuran with a concentration of 10-15% by weight. Weigh camptothecin at a drug / polylactide ratio of 1:20-1:30. Place in the above solution, mix and stir. Weigh the amphiphilic block copolymer at a ratio of 1:1-1:15 amphiphilic block copolymer / polylactide. Place the amphiphilic block copolymer in the above solution and mix, stir and swirl to form a uniform mixed solution .

[0068] 3. Preparation of a stent with drug temperature-sensitive and controlled-release effect

[0069] A tracheal stent (MTN tracheal stent, nickel-titanium alloy materia...

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Abstract

The invention relates to a bracket with a drug temperature-sensitive controlled-release function, which consists of a supporting bracket and a drug-carrying coating which covers the surface of the bracket, wherein the drug-carrying coating is formed by applying the coating with the drug temperature-sensitive controlled-release function on the surface of the bracket in the modes of spin coating, dip coating or spray coating. The invention also provides a coating with the drug temperature-sensitive controlled-release function and the application thereof. The coating with the drug temperature-sensitive controlled-release function has good temperature sensibility and drug controlled release function, can be evenly applied on the surface of bracket material. The drug-carrying bracket can effectively kill cancer cells and restrain the proliferation of nude mouse cancer transplantation tumor.

Description

【Technical Field】 [0001] The invention relates to a stent, in particular to a tumor therapeutic stent with temperature-sensitive and controlled-release effects of drugs and its application. 【Background technique】 [0002] In the field of interventional therapy, for the stenosis of blood vessels, trachea, esophagus, urethra, biliary tract and other organs, stents are usually implanted to expand the stenosis and effectively maintain the smoothness of the lumen. The stent is introduced into the lumen in the unexpanded state and positioned at the stenosis, expanded and placed there. Later, people invented drug-eluting stents on the basis of stents. Drug-eluting stents are also called drug-releasing stents. Drugs are carried by the polymer coated on the surface of the metal stent. When the stent is placed in the lesion in the lumen, the drug The drug is released from the polymer coating by elution. The current drug-eluting stents are more directly loaded with hydrophobic polymers su...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61F2/82
Inventor 李松岗全志伟谭庆刚王雪峰
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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