80 results about "Tracheal stent" patented technology

A tracheal stent is an expandable tubular member having a proximal end, a distal end, an inner surface, and an outer surface. Circumferentially adjacent surface protrusions extend outwardly from the outer surface of the expandable tubular member. These surface protrusions have an outer surface, a first lateral surface and a second lateral surface. When the tracheal stent is deployed, the outer surface of the surface protrusion applies a radial force to a wall of the trachea to remove an airway constriction.

Devices used in the management of bodily airways including bronchial and tracheal stents, bronchial Y-tubes, bronchial TY-tubes, nasal septal buttons, and nasal stents. The present invention also relates to devices used to manage the esophagus, such as salivary bypass tubes. These devices may comprise a fiber mesh imbedded in the walls of the device in order to provide integrity to the device wall and permit anchoring and suturing of the device.

An airway stent with an integral suture anchor is used to prevent migration of the stent within the airway. The suture anchor is incorporated by percutaneous placement of a suture through the neck and into the stent. The distal end of the suture includes an anchor element to secure the suture to the stent. The opposite end of the suture is tensioned and held in place by a suture clamp and a pledget routed over the stent and placed against the neck. Airway stents such as tracheal stents are effective at maintaining airway patency however; a common complication is stent migration. The integral suture anchor provides a reliable, economical, and non-intrusive solution to stent migration.

The invention relates to a tracheal stent and application thereof. The tracheal stent comprises supporting rings and a supporting connecting rod, wherein the various supporting rings are of C-shaped structures and are serially connected by virtue of the supporting connecting rod, so that the various supporting rings are integrally fixed with the supporting connecting rod. The invention further provides a tissue engineering trachea, and the tissue engineering trachea is prepared by winding a chondrocyte-gelatin / polycaprolactone electrospun membrane complex on the outer surface of the tracheal stent. The tracheal stent or the tissue engineering trachea disclosed by the invention can be used for repairing tracheal stenosis by virtue of a tracheal external support suspension method, and a new C-shaped cartilaginous ring is formed after the implantation of the tracheal stent or the tissue engineering trachea, so as to guarantee growth potential finally.

The invention discloses a 4D-printing shape-memory-polymer-composite-material tracheal stent and a preparing method thereof, and belongs to the technical field of 4D printing. As for the problem thata traditional tracheal stent is difficult to implant, and the secondary stricture problem caused by the overlarge hole diameter of the tracheal stent, and the problem that as the hole diameter of thetracheal stent is over small, swinging of airway cilia is blocked, a compound of a shape memory polymer and nanometer iron oxide serves as a material, a curve-edge rectangle serves as a basic unit, and a tracheal-stent three dimensional structure model is designed; the tracheal-stent three dimensional structure is printed and formed with the fused deposition or direct writing printing method, is subjected to electrostatic spinning medicine carrying covering, and then is subjected to in-vitro remote excitation so that the shape of the stent is recovered, and a formed tracheal stent is obtained.The 4D-printing shape-memory-polymer-composite-material tracheal stent and the preparing method thereof are suitable for production of the tracheal stent.

The invention provides a tracheal stent, a tissue engineering trachea adopting the tracheal stent and application of the tracheal stent and tissue engineering trachea. The tracheal stent comprises a plurality of supporting rings which are arranged at intervals, wherein a hollow reticular supporting part is arranged between adjacent supporting rings. The tracheal stent has the advantages of excellent supporting capacity, relatively good cartilage which is identified by a dyeing means can be formed within two weeks and can be directly used for transplanting, while the stent reported in the prior art can be transplanted for at least two months generally; and the tracheal stent in the prior art is cultured in vitro firstly, subcutaneously pre-transplanted on animals and then is taken out for transplanting, but the cartilage formed by virtue of the tracheal stent within two weeks can be transplanted without animal subcutaneous pre-transplanting.

A bioabsorbable tracheal stent is provided. The bioabsorbable stent comprises a biodegradable polymer, wherein the “ biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. A drug is dispersed within or dissolved in the biodegradable polymer. In a second and third aspect, the invention relates to methods of manufacturing a bioabsorbable tracheal stent. The first method includes forming a solution comprising a biodegradable polymer and a drug, the biodegradable polymer comprising about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. The method further comprises casting the solution to form the bioabsorbable tracheal stent. The second method includes forming a polymeric stent, and dip casting the polymeric stent in a solution comprising a biodegradable polymer and a drug to form a coating on the polymeric stent, wherein the biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof.

The invention discloses a medicine-carrying nanofiber membrane biliary stent and a preparation method thereof. The medicine-carrying nanofiber membrane biliary stent comprises one part of nanofiber inner layers, the other part of nanofiber inner layers, a metal support and a medicine-carrying degraded fiber outer layer from inside to outside, wherein one part of nanofiber inner layers are arrayed in the pipe diameter direction, and the other part of nanofiber inner layers are arrayed disorderly. The nanofiber inner layers arrayed in the pipe diameter direction and the nanofiber inner layers arrayed disorderly are bonded together. The nanofiber inner layers arrayed disorderly and the medicine-carrying degraded fiber outer layer are boned together through meshes of the metal support, and the metal support is firmly fixed in a fiber membrane. The preparation method includes that electrostatic spinning equipment is adopted for electrostatic spinning. Compared with a micro-nano ball, the nanofiber membrane biliary stent has better structural stability, can be used for treating biliary stricture caused by tumors, has a mechanical expansion effect and a local treatment function, and can solve the biliary malignant stricture better than a common stent or a membrane-covering stent. In addition, the method can be applied to gastrointestinal tract stents and tracheal stents.

Tracheal stents may include a plurality of wave form structures each extending radially about the support structure, a plurality of axial loop members extending axially between adjacent wave form structures and a polymeric covering disposed thereover. Tracheal stents may include an expandable metal structure and a plurality of spacer fins extending above an outer surface of the expandable metal structure. The plurality of spacer fins may be formed of a material different than that of the expandable metal structure.

In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and / or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

The invention relates to a 4-axis 3D-printing tubular medical stent as well as a preparation method and application thereof. The 4-axis 3D-printing tubular medical stent comprises a tubular stent witha multi-stage pore structure; and the surface of the stent is coated with nanofibers so as to form a double-layer tubular stent used for tubular tissue repair, extravascular stents, artificial tracheal stents and the like. The 4-axis 3D-printing tubular medical stent solves the problem of difficult direct construction of porous tubular stents by extrusion-type, especially fused-deposition-molding-type (FDM-type), 3D printing; and the prepared medical stent has the advantages of being possessed of a precise and controllable multi-stage pore structure, simple in application method, quick to useand suitable for multiple materials. And thus, the 4-axis 3D-printing tubular medical stent has good application prospects in the field of repair of tubular tissues and organs, including blood vessels, trachea, esophagus, urethra and the like.

Devices used in the management of bodily airways including bronchial and tracheal stents, bronchial Y-tubes, bronchial TY-tubes, nasal septal buttons, and nasal stents. The present invention also relates to devices used to manage the esophagus, such as salivary bypass tubes. These devices may comprise a fiber mesh imbedded in the walls of the device in order to provide integrity to the device wall and permit anchoring and suturing of the device.

The invention belongs to the technical field of medical instruments and relates to a nanogold film memory alloy esophageal stent with a photo-thermal therapy function. A nanogold film is prepared by conducting in-situ surface chloroauric acid reduction on a high polymer material with a reduction function used for modifying the surface of a memory alloy wire under the alkaline condition. According to the preparing method, a unique nanogold surface coating method is adopted, the nanogold material is safe and free of toxicity, and the coating process is simple and quick; photo-thermal efficiency is high, and repeated use is realized. The method can be applied to nickel-titanium alloy stents in various shapes and types such as a biliary stent, an intestinal tract stent, a urinary tract stent and a tracheal stent.

Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is an absorbable esophageal or tracheal stent. In some embodiments, the device is a vascular stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. An ointment comprising a collagen inhibitor is further provided. Kits comprising the coated substrates are also provided.

The invention discloses a 3D print tracheal stent. The tracheal stent comprises an inner stent and an outer stent, wherein the inner stent and the outer stent are each arranged as ring-shaped stent, and the outer diameter of the outer stent is larger than that of the inner stent, while the thickness of the inner stent is larger than that of the outer stent, and the space between the inner stent and the outer stent is connected through uniformly distributed support rods; the center of the inner stent is arranged as a central trachea. By the 3D print tracheal stent, the central tracheal stents are arranged as two layers, the central trachea is arranged in the center hole inside the inner stent; the inner and outer support structures can be arranged in several ways: spiral shape, dot-like distribution, linear or circular structure, the external supports of different structures can be adapted to different medical symptoms, and the solid support degrees of these structures are all very strong, and the stent has the characteristics of being small in stress area, significant in reducing the degree of stimulation of the trachea, and easy to use.

Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.

The invention discloses a multi-thermoplastic shape memory polymer 4D printing method. According to the multi-thermoplastic shape memory polymer 4D printing method, two or more thermoplastic shape memory polymers are adopted as a raw material, a solid structure is finally obtained through multiple steps of raw material wire drawing, target structure modeling and step-by-step fused deposition printing, initial structure modeling, programming mold manufacturing, shape programming and the like, and under the effect of the gradually-increased temperature, the solid structure can be recovered to atarget structure through step deformation. The multi-thermoplastic shape memory polymer 4D printing method can be widely applied to medical instruments such as tracheal stents and esophageal stents, gradually expands tissues such as trachea and esophagus, recovers organ functions and helps rehabilitation, and has important practical value.

The invention discloses a carbon fiber / carbon composite material C-shaped artificial tracheal stent with high biological activity and a preparation method thereof. The C-shaped artificial tracheal stent is composed of a single C-shaped tracheal stent unit, or is composed of two or more C-shaped tracheal stent units which are combined side by side or assembled into a continuous hollow tubular structure with an axial notch in the side wall. The main body of the C-shaped tracheal stent unit is a U-shaped or pear-shaped hollow banded structure , and the hollow is filled with bioactive materials. The tracheal stent has good biocompatibility and mechanical properties, high surface hardness and small friction coefficient, has a communicated space for blood supply, has a similar elastic modulus tocartilage, has a high goodness of fit with the biomechanical property of a tracheal port, particularly it is similar to a tracheal cartilage ring structure, and during the breathing process, througha C-shaped opening,the tracheal stent can be retracted or expanded to meet physiological functions.

The present invention provides a biological composite artificial trachea and its preparation method in combination with 3D printing technology. The material used in the present invention has both flexibility and certain mechanical strength, which meets the physical and mechanical properties of the trachea as a hollow organ in the thoracic cavity; secondly, The artificial trachea of ​​the present invention has a porous and loose structure, which is conducive to the diffusion of nutrients and the growth of autologous blood vessels; in addition, the present invention prints the seed cells obtained from the expansion of the recipient's own airway epithelial cells and chondrocytes in the trachea wall, The patient's rejection of the cells is avoided; moreover, the seed cells are composed of terminally differentiated mature cells, which avoids the problem of inducing differentiation and the risk of tumor formation caused by the use of stem cells; at the same time, the spatial distribution of the cells in the present invention is The printing is precise and controllable, and the distribution according to histological laws accelerates the repair process; finally, the tracheal stent can be degraded in the body, reducing the complications caused by foreign body residues in the body, and avoiding the risk of secondary surgical removal.

The invention relates to a trachea support and its application. The trachea stent is provided with support rings and support links, each of the support rings is C-shaped, and each support ring is connected in series by support links, so that each support ring and support links are fixed into one. The present invention also provides a tissue engineered trachea, which is made by wrapping the chondrocyte-gelatin / polycaprolactone electrospun membrane composite on the outside of the trachea stent. Using the tracheal stent or tissue engineered trachea of ​​the present invention, the tracheal stenosis can be repaired by the extratracheal support suspension method, and a new C-shaped cartilage ring can be formed after implantation, finally making it have the potential to grow.

The invention relates to a PCL (polycaprolactone) slow-degradation tracheal stent. The stent comprises an outer stent and an inner stent, wherein the outer stent is a hollow C-shaped circular tube, the inner stent is a hollow circular tube, a hollow C-shaped ring is arranged on the outer surface of the outer stent, and the inner stent is embedded in the outer stent. The invention further providesa slow-degradation tissue engineering trachea and an application thereof. The tracheal stent has the advantages as follows: the tracheal stent is completely bionic in terms of organizational structure, the outer layer is tracheal cartilage, and the inner layer is ciliated columnar epithelium, tracheal toughness is achieved, expectoration capacity is maintained, and the incidence of infection aftertransplantation can be reduced; moreover, the tracheal ring is incomplete, has growth potential and can be applied to minor organisms. The tracheal stent can be made into any diameter, and can meet individualized requirements. The PCL stent can be degraded in vivo completely and slowly and is non-toxic to bodies.

An airway stent with an integral suture anchor is used to prevent migration of the stent within the airway. The suture anchor is incorporated by percutaneous placement of a suture through the neck and into the stent. The distal end of the suture includes an anchor element to secure the suture to the stent. The opposite end of the suture is tensioned and held in place by a suture clamp and a pledget routed over the stent and placed against the neck. Airway stents such as tracheal stents are effective at maintaining airway patency however; a common complication is stent migration. The integral suture anchor provides a reliable, economical, and non-intrusive solution to stent migration.

The invention discloses a manufacturing method of a controllable antibacterial tracheal stent. The manufacturing method comprises the following steps of S1, preparing an antibacterial solution and a biocompatible degradable substrate material; S2, according to requirements, determining the geometric parameters and antibacterial component concentration of a degradable antibacterial layer at the surface of a substrate of the tracheal stent; S3, according to the geometric parameters and antibacterial component concentration in S2, calculating the printing route and printing parameters; S4, according to the printing route and printing parameters in S3, printing a degradable antibacterial mixing material at the surface of the substrate of the tracheal stent; S5, curing the printed degradable antibacterial mixing material, and curing the degradable antibacterial layer into a film. After the tracheal stent manufactured by the method is implanted into a human body, the antibacterial componentsare released along with the gradual degrading of the degradable substrate material; the release rate, concentration, antibacterial time and the like of the antibacterial components are controlled bycontrolling the antibacterial component concentration and the geometric parameters of the antibacterial layer, so that the implanted tracheal stent can reach the controllable antibacterial effect.

The invention discloses a bionic tracheal stent mounted in a trachea. The bionic tracheal stent comprises a stent body. The portion, corresponding to a cricothyroid membrane of the trachea, of the stent body is of a non-closed structure. The bionic tracheal stent has the advantages that the non-closed structure is arranged at the portion, corresponding to the cricothyroid membrane of the trachea of a human body, of the stent body, an arc-shaped structure made of a soft material is produced or two ends of the stent body extend in a staggered mode to enable the tracheal stent to form a helical structure, and the arc-shaped structure or the helical stent bends towards the interior of the stent body to reduce stress effect when the trachea is squeezed to contract, so that diameter change of the tracheal stent is limited, fatigue breakage of the stent due to stress contraction is reduced, and service life of the tracheal stent is prolonged.

The invention relates to a 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application. The 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent comprises a PLLA degradable tracheal stent of which outer layer is provided with an incomplete tracheal ring, and a PLLA degradable tracheal stent of which inner layer is free from the incomplete tracheal ring; the PLLA degradable tracheal stent of which outer layer is provided with the incomplete tracheal ring is composed of an outer layer PLLA degradable tracheal stent and an incomplete tracheal ring; the side face of the outer layer PLLA degradable tracheal stent is provided with a bracket notch penetrated through the pipe wall and several incomplete tracheal rings; one penetrated tracheal ring notch is arranged on the incomplete tracheal ring; the PLLA degradable tracheal stent of which inner layer is free from the incomplete tracheal ring is embedded in the pipe of the PLLA degradable tracheal stent of which outer layer is provided with the incomplete tracheal ring. The 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent has the advantages of achieving complete simulation, and keeping the tracheal flexibility as well as the sputum excretion ability, reducing occurrence rate of infection after transplanting; the tracheal stent can be applied to juvenile body; the tracheal stent can be degraded in the body and is free from toxic and harm to the body.

The invention relates to a preparation method of an anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and a product thereof. Biological elastic body poly 1, 8- octylene glycol-citric acid (POC) and polycaprolactone (PCL) are main structural materials of a mechanical support, nano-sized hydroxyapatite particles (Hap) are used as a filler and are mixed with POC-PCL to form POC-PCL / Hap master batch, and then a degradable tracheal stent material is prepared by a three-dimensional printing method through melt deposition forming. The stent consists of a tubular body, four symmetrical circular holes are formed in the edge of the body and are used for fixing an air pipe, the surface of the stent is smooth and corrugated, the diameter of the stent is 2cm, the length of the stent is 6cm, and an array of holes are distributed on the corrugated curved surface of the stent. The tracheal stent has the advantages of accurate implantation, convenient operation, acceleration of postoperative healing, good stability, firmness and difficulty in releasing.

The invention discloses an anti-infection nasal vestibule covered stent and a preparation method and application thereof, the nasal vestibule covered stent comprises a stent body, the shape and size of the stent body are matched with the shape of a nasal vestibule; and a covering film, wherein the covering film is compounded on the stent body. The stent body has a shape memory function and is well matched with the form structure of the nasal vestibule of a human body. The covering film is composed of at least one fiber layer, and the aperture of the fiber layer is gradually reduced from the lowermost layer of the lower covering film to the uppermost layer of the upper covering film in a gradient mode. The nasal vestibule covered stent provided by the invention can achieve gradient filtration of gas inhaled into a human body through a nose, and achieves the purpose of preventing bronchial, microbronchial and pulmonary infection of an artificial trachea or tracheal stent transplantation patient. The stent is simple in structure, convenient to manufacture, attractive in application and remarkable in anti-infection effect, medicine carrying and medicine releasing of the covered stent can be achieved, and the stent has multiple additional function attributes.

The invention belongs to the technical field of medical instruments, and relates to a memory alloy esophageal stent with a uniform nano copper sulfide film and an efficient photo-thermal physiotherapy function and a preparation method of the memory alloy esophageal stent. The stent is prepared by reducing dopamine under an alkaline condition to obtain a polydopamine-coated memory alloy stent, and then efficiently adsorbing copper ions through polydopamine under a heating condition to grow copper sulfide in situ. According to the method, a unique method for in-situ growth of nano CuS particles on the surface of the stent is adopted, the nano CuS material is safe and non-toxic, and the growth process is simple and rapid; photo-thermal conversion is efficient, and repeated use can be achieved; the method can be applied to nickel-titanium alloy stents of various shapes and other types, such as biliary tract stents, intestinal tract stents, urinary tract stents and tracheal stents.

The invention provides a bionic composite artificial trachea. The bionic composite artificial trachea comprises an artificial trachea wall, a trachea stent arranged on the outer side of the artificialtrachea wall and a gasket wrapping the edge of the trachea stent, wherein the artificial trachea wall comprises a biological patch layer and an absorbable biological material layer from inside to outside. According to the bionic composite artificial trachea, the biological patch layer and the absorbable biological material layer serve as the artificial trachea wall, and the trachea stent is arranged, so that ventilation is good, the bionic composite artificial trachea can deform slightly along with airway pressure and has certain telescopic elasticity, the head of a patient can move freely, and the trouble that the neck needs to be fixed after a traditional trachea operation is avoided; meanwhile, the gasket can prevent the tail end of the trachea stent from contusion of surrounding organs due to friction at the initial stage of implantation; in conclusion, the bionic composite artificial trachea provided by the invention can realize clinical application, and can solve the problem that no effective trachea substitute is available for first-stage trachea reconstruction when an ultra-long trachea is excised in a tracheal surgical operation at present in one operation.

The invention relates to an elastic degradable tracheal stent and a construction method thereof. The stent is of a three-layer elastic tracheal shape composite structure, and successively includes a PGS tube core, C-type PCL rings arranged in parallel and a PCL sheath layer from inside to outside; the PGS tube core is of a tubular structure made of a poly(glycerol-sebacate) material; the C-type PCL rings are of C-type structures made of polycaprolactone, and the PCL sheath layer is a polycaprolactone sheath layer prepared by electrospinning. According to the elastic degradable tracheal stent and the construction method thereof, by constructing a three-layer elastic tracheal shape composite scaffold material with the PGS tube core-C-type PCL rings-PCL sheath layer, a tracheal scaffold material with good elasticity, good pore connectivity, good support and timely degradation is obtained, the tracheal scaffold material is superior to other tissue engineering materials in the past, the scaffold material can realize the advantages of rapid vascularization, good tissue infiltration, good flexibility and the like, and the scaffold material paves the way for follow-up application in clinical researches.