Manufacturing method of controllable antibacterial tracheal stent

Abstract

The invention discloses a manufacturing method of a controllable antibacterial tracheal stent. The manufacturing method comprises the following steps of S1, preparing an antibacterial solution and a biocompatible degradable substrate material; S2, according to requirements, determining the geometric parameters and antibacterial component concentration of a degradable antibacterial layer at the surface of a substrate of the tracheal stent; S3, according to the geometric parameters and antibacterial component concentration in S2, calculating the printing route and printing parameters; S4, according to the printing route and printing parameters in S3, printing a degradable antibacterial mixing material at the surface of the substrate of the tracheal stent; S5, curing the printed degradable antibacterial mixing material, and curing the degradable antibacterial layer into a film. After the tracheal stent manufactured by the method is implanted into a human body, the antibacterial componentsare released along with the gradual degrading of the degradable substrate material; the release rate, concentration, antibacterial time and the like of the antibacterial components are controlled bycontrolling the antibacterial component concentration and the geometric parameters of the antibacterial layer, so that the implanted tracheal stent can reach the controllable antibacterial effect.

Description

technical field [0001] The invention relates to the technical field of tracheal stents, in particular to a method for manufacturing a controllable antibacterial tracheal stent. Background technique [0002] Tracheal and bronchial stenosis can be caused by a variety of etiologies, including: inflammatory granuloma, trauma, tracheomalacia, tumor, etc. Tracheal stenosis can cause obstructive pneumonia, atelectasis, and dyspnea, and in severe cases, respiratory failure can occur in patients and be life-threatening. [0003] Tracheal stent implantation is one of the important means for the treatment of tracheal stenosis, which can quickly relieve dyspnea. Improve clinical symptoms. At present, the tracheal stents that are widely used clinically mainly include metal stents and silicone stents. Metal tracheal stents are mostly made of titanium-nickel memory alloy or stainless steel to weave into a meshed circular tube shape, and can be divided into covered stents and bare stents...

AI Technical Summary

Problems solved by technology

[0005] The tracheal stent can be placed in the human body for a short or long term. Clinically, the stent is placed in an open environment (same as the air) after the stent is placed, and is easily infected by microorganisms brought in by respiratory movement. Because there is no blood circulation on the surface of the stent, there are no cells. Immune function, so after surgery, bacteria are easy to colonize and multiply on the stent and are difficult to remove, resulting in repeated airway infections after the stent is placed, and even endanger the patient's life

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