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Bionic composite artificial trachea and preparation method thereof

A technology of artificial trachea and tracheal stent, which is applied in the field of bionic composite artificial trachea and its preparation, can solve the problem of no trachea substitute, and achieve the effects of reducing the chance of infection and rupture, easy control, and good ventilation

Pending Publication Date: 2020-09-11
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, the purpose of the present invention is to provide a bionic composite artificial trachea and its preparation method. The bionic composite artificial trachea provided by the present invention can realize clinical application, and can solve the problem of ultra-long trachea resection in current tracheal surgery in one operation. Problems with primary tracheal reconstruction without effective tracheal substitutes

Method used

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  • Bionic composite artificial trachea and preparation method thereof
  • Bionic composite artificial trachea and preparation method thereof
  • Bionic composite artificial trachea and preparation method thereof

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preparation example Construction

[0055] The present invention also provides a method for preparing the bionic composite artificial trachea described in the above technical solution, comprising the following steps:

[0056] a) Cover the bio-patch layer with the absorbable biomaterial layer, and then evenly wrap the same mold as the autologous trachea with one side of the bio-patch layer, and after cutting and suturing to obtain the artificial trachea wall; A tracheal stent is set on one side of the layer; finally, the edge of the tracheal stent is wrapped with a gasket to obtain a bionic composite artificial trachea.

[0057] In the present invention, the absorbable biological material layer is firstly covered on the biological patch layer, and then the same mold as the autologous trachea is uniformly wrapped on one side of the biological patch layer, and the artificial trachea wall is obtained after cutting and suturing. In the present invention, the absorbable biomaterial layer and the biopatch layer are the...

Embodiment 1

[0076] Carbon fiber C-shaped external stent combined with bovine pericardial patch to make artificial trachea for tracheal reconstruction after ultra-long (8.6cm) tracheectomy:

[0077] see figure 1 as shown, figure 1 Schematic diagram of the structure of the biomimetic composite artificial trachea provided in Example 1; wherein, the white part is the biological patch layer, and the sky blue part is the absorbable biomaterial layer, covering the outer periphery of the biological patch layer, and the two form a closed artificial trachea wall (tubular), and make the corresponding diameter and length according to the actual needs in the operation; multiple carbon fiber C-shaped external stents are sutured side by side on the outer periphery of the artificial trachea wall, and the width of each carbon fiber C-shaped external stent is 4mm-8mm, and the interval is 5mm-10mm (depending on the situation during the operation); the white strip is a polyester felt pad, which wraps both e...

Embodiment 2

[0092] One case of repairing the wall of trachea and right main bronchus (4cm) with carbon fiber overall external stent combined with autologous pericardial patch.

[0093] ◆Medical records: Patient: Male; 56 years old, physical examination revealed a tracheal tumor for more than 2 months.

[0094] ◆History of present illness: A mass on the right wall of the lower trachea was found in the physical examination 2 months before the operation, accompanied by a mild dry cough.

[0095] Further bronchoscopic biopsy diagnosis: low-grade schwannoma. One month before the operation, CT showed "the new growth on the right side wall near the bifurcation of the lower trachea and the opening of the right main bronchus, accompanied by stenosis of the lumen. The general condition is acceptable.

[0096] ◆Contrast-enhanced CT of the lungs: New organisms on the right wall near the bifurcation of the lower trachea and at the opening of the right main bronchus, accompanied by stenosis of the lum...

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Abstract

The invention provides a bionic composite artificial trachea. The bionic composite artificial trachea comprises an artificial trachea wall, a trachea stent arranged on the outer side of the artificialtrachea wall and a gasket wrapping the edge of the trachea stent, wherein the artificial trachea wall comprises a biological patch layer and an absorbable biological material layer from inside to outside. According to the bionic composite artificial trachea, the biological patch layer and the absorbable biological material layer serve as the artificial trachea wall, and the trachea stent is arranged, so that ventilation is good, the bionic composite artificial trachea can deform slightly along with airway pressure and has certain telescopic elasticity, the head of a patient can move freely, and the trouble that the neck needs to be fixed after a traditional trachea operation is avoided; meanwhile, the gasket can prevent the tail end of the trachea stent from contusion of surrounding organs due to friction at the initial stage of implantation; in conclusion, the bionic composite artificial trachea provided by the invention can realize clinical application, and can solve the problem that no effective trachea substitute is available for first-stage trachea reconstruction when an ultra-long trachea is excised in a tracheal surgical operation at present in one operation.

Description

technical field [0001] The invention relates to the technical field of artificial trachea, and more specifically relates to a bionic composite artificial trachea and a preparation method thereof. Background technique [0002] Surgical resection is still the main treatment for tracheal diseases such as tracheal tumor and tracheal stenosis. By removing tracheal lesions and restoring ventilation function, the purpose of treating diseases and improving symptoms can be achieved. However, the resectable length of the trachea is limited. The maximum length of the resected trachea in adults is 4-6 cm. When the resected trachea exceeds this length, in situ anastomosis is extremely difficult. At this time, a suitable tracheal substitute is needed to connect the upper and lower tracheal remnants. end. At present, there are no mature tracheal substitutes that can be applied to tracheal reconstruction in thoracic surgery. Therefore, when the trachea involved by tumors or lesions exceed...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61L27/40A61L27/58A61L27/36A61L27/50A61L27/18
CPCA61F2/04A61F2002/046A61F2210/0004A61F2210/0057A61F2220/0008A61F2240/001A61L27/18A61L27/3604A61L27/3679A61L27/50A61L27/58A61L2430/22C08L67/04
Inventor 王彬彭慕云喻风雷王翔钱邦伦胡琪康梁恒星黄奇曾超舒陆
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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