Elastic degradable tracheal stent and construction method thereof

Abstract

The invention relates to an elastic degradable tracheal stent and a construction method thereof. The stent is of a three-layer elastic tracheal shape composite structure, and successively includes a PGS tube core, C-type PCL rings arranged in parallel and a PCL sheath layer from inside to outside; the PGS tube core is of a tubular structure made of a poly(glycerol-sebacate) material; the C-type PCL rings are of C-type structures made of polycaprolactone, and the PCL sheath layer is a polycaprolactone sheath layer prepared by electrospinning. According to the elastic degradable tracheal stent and the construction method thereof, by constructing a three-layer elastic tracheal shape composite scaffold material with the PGS tube core-C-type PCL rings-PCL sheath layer, a tracheal scaffold material with good elasticity, good pore connectivity, good support and timely degradation is obtained, the tracheal scaffold material is superior to other tissue engineering materials in the past, the scaffold material can realize the advantages of rapid vascularization, good tissue infiltration, good flexibility and the like, and the scaffold material paves the way for follow-up application in clinical researches.

Description

technical field

[0001] The invention relates to the technical field of biomedical devices, in particular to an elastic degradable tracheal stent and a construction method thereof. Background technique

[0002] Tracheal tumors, tracheal trauma, or congenital tracheal deformities often lead to tracheal stenosis and even seriously threaten the lives of patients. Clinically, the incidence of tracheal malformation is high in children with congenital heart disease. According to literature reports, tracheal malformation accounts for about 12.9% of children with congenital heart disease. In my country, the incidence of congenital heart disease accounts for 0.7%-0.8%, and it is increasing by about 150,000 children every year. Among them, many children with congenital heart disease are complicated with tracheal deformities every year. Tracheal stenosis is the most common form of tracheal malformation, and compression and softening of the trachea by cardiovascular malformations is on...

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