Elastic degradable tracheal stent and construction method thereof

A technique for tracheal stents and construction methods, applied in stents, coatings, medical science, etc., to achieve good tissue infiltration, good elasticity, and good pore connectivity

Active Publication Date: 2019-12-17
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Elastic degradable tracheal stent and construction method thereof
  • Elastic degradable tracheal stent and construction method thereof
  • Elastic degradable tracheal stent and construction method thereof

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[0043] The present invention will be described in detail below in combination with specific embodiments.

[0044] The invention relates to an elastic degradable tracheal stent, the stent is a three-layer elastic tracheal composite structure, which sequentially includes a PGS tube core, a C-shaped PCL ring and a PCL sheath arranged in parallel to form a PGS tube core-C Type PCL ring-PCL sheath has elastic degradable tracheal stent material.

[0045] The PGS core is a tubular structure made of polyglycerol sebacate (PGS) material; the C-shaped PCL ring is a C-shaped structure made of polycaprolactone (PCL); the PCL sheath The layer is a polycaprolactone sheath prepared by electrospinning. The C-type PCL ring is used as the middle supporting ring layer, including at least two rings, which are equal in size and arranged in parallel axially. The inner diameter of the stent is 4-9 mm, and the outer diameter is 6-11 mm; the width of the C-type PCL ring is 2-3 mm, and the adjacent d...

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Abstract

The invention relates to an elastic degradable tracheal stent and a construction method thereof. The stent is of a three-layer elastic tracheal shape composite structure, and successively includes a PGS tube core, C-type PCL rings arranged in parallel and a PCL sheath layer from inside to outside; the PGS tube core is of a tubular structure made of a poly(glycerol-sebacate) material; the C-type PCL rings are of C-type structures made of polycaprolactone, and the PCL sheath layer is a polycaprolactone sheath layer prepared by electrospinning. According to the elastic degradable tracheal stent and the construction method thereof, by constructing a three-layer elastic tracheal shape composite scaffold material with the PGS tube core-C-type PCL rings-PCL sheath layer, a tracheal scaffold material with good elasticity, good pore connectivity, good support and timely degradation is obtained, the tracheal scaffold material is superior to other tissue engineering materials in the past, the scaffold material can realize the advantages of rapid vascularization, good tissue infiltration, good flexibility and the like, and the scaffold material paves the way for follow-up application in clinical researches.

Description

technical field [0001] The invention relates to the technical field of biomedical devices, in particular to an elastic degradable tracheal stent and a construction method thereof. Background technique [0002] Tracheal tumors, tracheal trauma, or congenital tracheal deformities often lead to tracheal stenosis and even seriously threaten the lives of patients. Clinically, the incidence of tracheal malformation is high in children with congenital heart disease. According to literature reports, tracheal malformation accounts for about 12.9% of children with congenital heart disease. In my country, the incidence of congenital heart disease accounts for 0.7%-0.8%, and it is increasing by about 150,000 children every year. Among them, many children with congenital heart disease are complicated with tracheal deformities every year. Tracheal stenosis is the most common form of tracheal malformation, and compression and softening of the trachea by cardiovascular malformations is on...

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Application Information

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IPC IPC(8): A61F2/82D01D5/00B29C33/38B29C64/153B33Y10/00
CPCA61F2/82D01D5/0007D01D5/003D01D5/0084B29C64/153B29C33/3842B33Y10/00A61F2240/002
Inventor 吴炜加三三张心驰张思倩
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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