Preparation method of anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and product

A 3D printing and tracheal stent technology, which is applied in stents, prostheses, medical science, etc., can solve the problems of epithelial crawling and granulation formation in the lumen, which are easy to attach and crawl, firm and difficult to fall out, and easy to operate. Effect

Active Publication Date: 2019-04-19
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Artificial trachea materials have gradually developed from non-porous, hard, and single components to porous, biological, and composite components. The earliest artificial trachea was mostly made of Neville tube, which has strong plasticity, good air tightness, no leakage, and is not easy to leak. Infection, but the epithelium in the lumen is difficult to crawl. Hou Dongxiang, Lu Shiqian, Acocella et al. used polyester cloth to wrap the silicone tube for tracheal reconstruction and achieved good results, but the gap between the silicone tube and the trachea is still difficult to avoid the formation of granulation

Method used

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  • Preparation method of anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and product
  • Preparation method of anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and product
  • Preparation method of anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and product

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A method for preparing an anatomical 3D printed bellows-shaped elastomeric tracheal stent, using bioelastomer poly-1,8-octanediol-citric acid (POC) as the main structural material, and then preparing biodegradable stents by fused deposition modeling 3D printing Type tracheal stent material, follow the steps below:

[0031] Synthesis of POC: Put 1,8-octanediol and citric acid with a molar ratio of 1:1 in a three-necked flask, and heat it to 160°C under the protection of inert gas. The two monomers are completely melted and the reaction temperature is kept at 140°C. Continue stirring until the reaction Near the gel point, the prepolymer was dissolved in ethanol, and unreacted small molecules were precipitated with deionized water. After curing and cross-linking at 120°C, the POC raw material is obtained.

[0032] Cut the POC material into small pieces, stuff it into the printing cavity of the 3d plotter, preheat it at 110 degrees Celsius, and stack the layers with a heig...

Embodiment 2

[0037] A preparation method of anatomical 3D printing bellows-shaped elastomeric tracheal stent, using bioelastomers poly-1,8-octanediol-citric acid (POC) and polycaprolactone (PCL) as the main structural materials, and then by melting To prepare degradable tracheal stent material by deposition modeling 3D printing method, follow the steps below:

[0038] Synthesis of POC: Put 1,8-octanediol and citric acid PCL with a molar ratio of 1:1 in a three-necked flask, add 30% by mass water PCL material, heat to 160°C under the protection of an inert gas, and completely melt to maintain the reaction temperature at 140°C, continue to stir until the reaction is close to the gel point, dissolve the prepolymer in ethanol, and use deionized water to precipitate unreacted small molecules. The POC-PCL raw material is obtained after post-curing and cross-linking at 120°C.

[0039] First, cut the POC-PCL raw material into small pieces and fill them into the cavity of the Haake rheometer preheat...

Embodiment 3

[0044] A method for preparing an anatomical 3D printed bellows-shaped elastomer tracheal stent, using bioelastomers poly-1,8-octanediol-citric acid (POC) and polycaprolactone (PCL) as the main structural materials, nano-sized Hydroxyapatite particles (Hap) are used as a filler, mixed with POC-PCL to form a POC-PCL / Hap masterbatch, and then a degradable tracheal stent material is prepared by fused deposition modeling 3D printing, as follows:

[0045] Put 1,8 octanediol and citric acid POC with a molar ratio of 1:1 in a three-necked flask, add PCL material with 30% water by mass, heat to 160°C under the protection of inert gas, and completely melt to keep the reaction temperature at 140°C. Continue to stir until the reaction is close to the gel point, dissolve the prepolymer in ethanol, and use deionized water to precipitate unreacted small molecules. The POC-PCL raw material is obtained after post-curing and cross-linking at 120°C. Add about 1% of nano-hydroxyapatite powder by...

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Abstract

The invention relates to a preparation method of an anatomical type three-dimensional printing corrugated pipe elastic body tracheal stent and a product thereof. Biological elastic body poly 1, 8- octylene glycol-citric acid (POC) and polycaprolactone (PCL) are main structural materials of a mechanical support, nano-sized hydroxyapatite particles (Hap) are used as a filler and are mixed with POC-PCL to form POC-PCL/Hap master batch, and then a degradable tracheal stent material is prepared by a three-dimensional printing method through melt deposition forming. The stent consists of a tubular body, four symmetrical circular holes are formed in the edge of the body and are used for fixing an air pipe, the surface of the stent is smooth and corrugated, the diameter of the stent is 2cm, the length of the stent is 6cm, and an array of holes are distributed on the corrugated curved surface of the stent. The tracheal stent has the advantages of accurate implantation, convenient operation, acceleration of postoperative healing, good stability, firmness and difficulty in releasing.

Description

technical field [0001] The invention relates to the production of a degradable tracheal stent used in thoracic surgery, belongs to the application field of medical device preparation and processing, and relates to a method for preparing an anatomical 3D printed bellows-shaped elastic body tracheal stent and a product thereof. technical background [0002] Tracheal stenosis, tracheal defects caused by congenital diseases and tumors are difficult to repair. Partial resection of tracheal lesions is often performed to treat diseases and improve symptoms. Conventional resection is difficult to meet the needs of patients. Therefore, tracheal transplantation has become An important developmental branch of tracheal surgery, it has become an important means of reconstruction after long segmental resection of the trachea. The key to reconstructive surgery mainly depends on the length of the trachea that can be resected and tension-free anastomosis can be performed. It is generally bel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82
CPCA61F2/82A61F2002/821A61F2210/0004A61F2240/002
Inventor 何丹农严一楠冯耘王杰林许晓雷杨迪诚王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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