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3D printed embeddable double-layer PCL (polycaprolactone) slow-degradation tissue engineering tracheal stent with incomplete tracheal ring and application of stent

A technology for tracheal stents and degraded tissues, which is applied in the field of medical devices to achieve slow degradation, reduce the incidence of infection, and solve the effects of construction difficulties

Pending Publication Date: 2018-05-04
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about a 3D printed incomplete tracheal ring of the present invention that can be embedded with double-layer PCL slow-degradation tissue engineering tracheal stent and its application.

Method used

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  • 3D printed embeddable double-layer PCL (polycaprolactone) slow-degradation tissue engineering tracheal stent with incomplete tracheal ring and application of stent
  • 3D printed embeddable double-layer PCL (polycaprolactone) slow-degradation tissue engineering tracheal stent with incomplete tracheal ring and application of stent
  • 3D printed embeddable double-layer PCL (polycaprolactone) slow-degradation tissue engineering tracheal stent with incomplete tracheal ring and application of stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Slowly degrading tracheal stent

[0036] Please refer to the attached Figure 1-4 , with figure 1 It is a schematic diagram of the structure of a slowly degrading tracheal stent, with figure 2 It is a schematic top view of a slowly degrading tracheal stent, with image 3 is the schematic diagram of the structure of the outer support, with Figure 4 is a schematic diagram of the structure of the inner layer bracket.

[0037] The slowly degrading tracheal stent is composed of an outer stent 1 and an inner stent 2, the outer stent 1 is a hollowed-out C-shaped round tube, the inner stent 2 is a hollowed-out round tube, and the outer stent 2 is a hollowed-out round tube. A hollow C-shaped ring 11 is provided on the outer surface of the layer bracket 1 , and the inner layer bracket 2 is embedded in the outer layer bracket 1 .

[0038] The slowly degradable tracheal stent can be made of materials including but not limited to PCL that can degrade slowly in the...

Embodiment 2

[0042] Example 2: Slowly degrading tracheal stent

[0043] Please refer to the attached Figure 1-4 , with figure 1 It is a schematic diagram of the structure of a slowly degrading tracheal stent, with figure 2 It is a schematic top view of a slowly degrading tracheal stent, with image 3 is the schematic diagram of the structure of the outer support, with Figure 4 is a schematic diagram of the structure of the inner layer bracket.

[0044] The material of the slowly degrading tracheal stent is PCL, and the slowly degrading tracheal stent is composed of an outer stent 1 and an inner stent 2, the outer stent 1 is a mesh C-shaped round tube, and the inner stent The layer support 2 is a mesh-shaped round tube, and the outer surface of the outer layer support 1 is provided with a hollow C-shaped ring 11 , and the inner layer support 2 is embedded in the outer layer support 1 . The inner diameter of the outer stent 1 is 5.1 mm, and the length of the C-shaped notch of the ou...

Embodiment 3

[0045] Example 3: Slowly degrading tracheal stent

[0046] Please refer to the attached Figure 5 , with Figure 5 It is a schematic diagram of the structure of a slowly degrading tracheal stent.

[0047] The material of the slowly degrading tracheal stent is PCL, and the slowly degrading tracheal stent is composed of an outer stent 1 and an inner stent 2, the outer stent 1 is a hollow C-shaped round tube, and the inner stent The layer support 2 is a hollowed-out circular tube, and the outer surface of the outer layer support 1 is provided with a hollow C-shaped ring 11, and the upper and lower edges of the outer layer support 1 are circular rings 12, and the inner layer The bracket 2 is embedded in the outer bracket 1 . The inner diameter of the outer stent 1 is 5.1 mm, and the length of the C-shaped notch of the outer stent 1 is 3 mm. The outer diameter of the inner layer stent 2 is 5 mm, and the inner diameter of the inner layer stent 2 is 4.5 mm. The height of the C-s...

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Abstract

The invention relates to a PCL (polycaprolactone) slow-degradation tracheal stent. The stent comprises an outer stent and an inner stent, wherein the outer stent is a hollow C-shaped circular tube, the inner stent is a hollow circular tube, a hollow C-shaped ring is arranged on the outer surface of the outer stent, and the inner stent is embedded in the outer stent. The invention further providesa slow-degradation tissue engineering trachea and an application thereof. The tracheal stent has the advantages as follows: the tracheal stent is completely bionic in terms of organizational structure, the outer layer is tracheal cartilage, and the inner layer is ciliated columnar epithelium, tracheal toughness is achieved, expectoration capacity is maintained, and the incidence of infection aftertransplantation can be reduced; moreover, the tracheal ring is incomplete, has growth potential and can be applied to minor organisms. The tracheal stent can be made into any diameter, and can meet individualized requirements. The PCL stent can be degraded in vivo completely and slowly and is non-toxic to bodies.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a slow-degradation tissue engineering trachea stent and its application. Background technique [0002] At present, the existing tissue engineering 3D printed polycaprolactone (PCL) scaffold is a complete tracheal ring, and it is a single layer. Only tracheal chondrocytes can be planted on the surface. This kind of scaffold is a complete tracheal ring and lacks growth potential. , and because of failure to plant ciliated columnar epithelial cells, there is no ability to excrete sputum, and infection is prone to occur after transplantation, resulting in failure of tracheal transplantation. [0003] The trachea is a complex organ composed of hyaline cartilage, epithelial tissue, and connective tissue. The cartilage ring plays a supporting role, and the epithelial tissue plays a cleaning and defense function. Based on the anatomical and physiological characteristics of the t...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61L27/18A61L27/38B33Y10/00B33Y80/00
CPCA61L27/18A61L27/3813A61L27/3817A61F2/04B33Y10/00B33Y80/00A61F2002/046A61F2230/0069A61F2210/0076A61L2430/22C08L67/04
Inventor 高波涛郑景浩何晓敏刘玉洁罗凯高漫辰
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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