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32 results about "Tracheal ring" patented technology

Degradable artificial trachea stent and production method thereof

The invention relates to a degradable artificial trachea support frame and a manufacturing method thereof, which belong to the technical field of biological medicine. The support frame is characterized by being weaved into a circular pipe shape by polyp-dioxygen cyclohexanone monofilaments or polyglycolic acid monofilaments; the longitudinal axles of a tracheal wall transversely surround a pipe-shaped annulet formed by weaving the double-layered monofilaments at intervals; the monofilaments on the inner layer of the tracheal wall are bond uniformly; collagen is uniformly covered on the surfaces of the monofilaments; and chitosan is covered on the collagen in sequence. The manufacturing method comprises the following steps: weaving the circular pipe-shaped annular support frame; dipping the support frame into 2 percent of collage solution and drying; coating chitosan solution on the surface of the inner layer; and drying for standby. After the invention is executed, the stimulation of patches to human tissues is reduced and the anti-infectious capacity is strong, so as to be beneficial to reconstruct tracheas; a double-layer structure can accommodate the support frame for rehabilitating tracheal rings and achieve double rehabilitations in aspects of physiological anatomy and function of the defective tracheas; and the coating layer of the chitosan is arranged on the inner layer, so as to be beneficial to the creeping rehabilitation of tracheal endothelium.
Owner:唐华 +3

3D printed embeddable double-layer PCL (polycaprolactone) slow-degradation tissue engineering tracheal stent with incomplete tracheal ring and application of stent

PendingCN107981954AHas growth potentialMaintain expectoration abilityAdditive manufacturing apparatusTracheae3d printInsertion stent
The invention relates to a PCL (polycaprolactone) slow-degradation tracheal stent. The stent comprises an outer stent and an inner stent, wherein the outer stent is a hollow C-shaped circular tube, the inner stent is a hollow circular tube, a hollow C-shaped ring is arranged on the outer surface of the outer stent, and the inner stent is embedded in the outer stent. The invention further providesa slow-degradation tissue engineering trachea and an application thereof. The tracheal stent has the advantages as follows: the tracheal stent is completely bionic in terms of organizational structure, the outer layer is tracheal cartilage, and the inner layer is ciliated columnar epithelium, tracheal toughness is achieved, expectoration capacity is maintained, and the incidence of infection aftertransplantation can be reduced; moreover, the tracheal ring is incomplete, has growth potential and can be applied to minor organisms. The tracheal stent can be made into any diameter, and can meet individualized requirements. The PCL stent can be degraded in vivo completely and slowly and is non-toxic to bodies.
Owner:SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Method for establishing animal in-vitro tracheal model for evaluating inflammatory response induced by tobacco mainstream smoke and evaluation method

The invention relates to a method for establishing an animal in-vitro tracheal model for evaluating inflammatory response induced by tobacco mainstream smoke and an evaluation method, and belongs to the technical field of cigarette hazard assessment. The method for establishing the animal in-vitro tracheal model comprises the following steps: 1) separating a tracheal ring; 2) culturing the tracheal ring obtained in the step 1) in vitro; and 3) exposing the tracheal ring cultured in the step 2) to a flue gas condensate for 1 to 24 hours. The evaluation method of the inflammatory response induced by the tobacco mainstream smoke comprises selection of evaluation indexes and division of evaluation criteria; and evaluation of the degree of the inflammatory response. The method has the followingadvantages: 1) the detection method of the tracheal inflammation after smoke exposure has high efficiency; 2) the detection method of the tracheal inflammation after smoke exposure has good repeatability and system stability and high accuracy; and 3) the use range is wide. The method can be applied to in vitro exposure models of cigarette mainstream smoke, sidestream smoke, ambient flue gas and other smoke aerosols.
Owner:ZHENGZHOU TOBACCO RES INST OF CNTC +1

3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application

PendingCN107854195AHas growth potentialMaintain expectoration abilityTracheae3d printTracheal tube
The invention relates to a 3D printed incomplete tracheal ring that can be embedded in a double-layer PLLA tissue engineering tracheal stent and its application, including a PLLA degradable tracheal stent with an incomplete tracheal ring on the outer layer and an incomplete inner layer The PLLA degradable tracheal stent with tracheal ring; the PLLA degradable tracheal stent with an incomplete tracheal ring on the outer layer is composed of an outer PLLA degradable tracheal stent and an incomplete tracheal ring; the side design of the outer PLLA degradable tracheal stent There is a stent gap through the tube wall and several incomplete tracheal rings; there is a through tracheal ring gap on the incomplete tracheal ring; the inner layer does not have a PLLA degradable tracheal stent nested with incomplete tracheal rings Inside the tube of a PLLA degradable tracheal stent with an incomplete tracheal ring on the outer layer. Its advantages are: completely bionic, which not only has the toughness of the trachea but also maintains the ability to expel sputum, reduces the incidence of infection after transplantation, and can be applied to minors; the tracheal stent can be degraded in the body and is non-toxic to the body.
Owner:SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Vibration detector and vibration detection method

The invention discloses a vibration detector and a vibration detection method. The vibration detector comprises a vibration assembly and a control assembly connected with the vibration assembly. The vibration assembly comprises a shell, a vibration motor arranged in the shell and a vibration head connected with the shell, wherein the vibration motor is connected with the control assembly; the side, away from the shell, of the vibration head is of a curved-surface-shaped structure. The curved-surface-shaped structure comprises transition arc surfaces located at two ends of the vibration head, and concave arc surfaces which are in smooth connection with the transition arc surfaces at the two ends and are externally tangent to the transition arc surfaces. The vibration detector disclosed by the invention is designed according to a special anatomical structure of a neck tracheal ring, so the vibration detector is matched with the neck trachea and the anatomical structure, the contact surface is not too large or too small, other tissues of the neck are not stimulated, the test result is accurate, cough sensitivity objective evaluation indexes based on physical stimulation are obtained,adverse reactions are avoided, and the compliance degree of a subject is higher.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1

An in vitro animal trachea model establishment method and evaluation method for evaluating tobacco mainstream smoke-induced inflammatory response

The invention relates to a method for establishing an animal in-vitro tracheal model for evaluating inflammatory response induced by tobacco mainstream smoke and an evaluation method, and belongs to the technical field of cigarette hazard assessment. The method for establishing the animal in-vitro tracheal model comprises the following steps: 1) separating a tracheal ring; 2) culturing the tracheal ring obtained in the step 1) in vitro; and 3) exposing the tracheal ring cultured in the step 2) to a flue gas condensate for 1 to 24 hours. The evaluation method of the inflammatory response induced by the tobacco mainstream smoke comprises selection of evaluation indexes and division of evaluation criteria; and evaluation of the degree of the inflammatory response. The method has the followingadvantages: 1) the detection method of the tracheal inflammation after smoke exposure has high efficiency; 2) the detection method of the tracheal inflammation after smoke exposure has good repeatability and system stability and high accuracy; and 3) the use range is wide. The method can be applied to in vitro exposure models of cigarette mainstream smoke, sidestream smoke, ambient flue gas and other smoke aerosols.
Owner:ZHENGZHOU TOBACCO RES INST OF CNTC +1
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