Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma

A technology of tracheal smooth muscle and diacerein, applied in the field of medicine

Inactive Publication Date: 2020-02-14
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Diacerein relaxes airway smooth muscle in the treatment of asthma, but there is no relevant report at home and abroad

Method used

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  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma
  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma
  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma

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Experimental program
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Effect test

Embodiment 1

[0044] 1. Experimental animals:

[0045] Healthy sexually mature male BALB / c mice, SPF grade, with an average age of 6-8 weeks were purchased from Hubei Provincial Center for Disease Control and Prevention (Wuhan, China). Optimum environment for raising mice: 12 hours (8:00-20:00) light-dark cycle, room temperature maintained at 20-25° C., and humidity maintained at 50-60%.

[0046] 2. Experimental consumables and equipment:

[0047]Microscope (IX71) (Olympus Corporation); dissecting mirror (XTL-2300) (Shanghai Precision Instrument Company); stereo microscope (SZM) (Wuhan Aispe Scientific Instrument Co., Ltd.); ultrapure water system (Aike Pu Company); biological function experiment system (BL-420S) (Chengdu Taimeng Technology Co., Ltd.); HV-4 type constant temperature perfusion system for isolated tissues and organs (Chengdu Taimeng Technology Co., Ltd.); tension transducer (JH-2 Type) (China Beijing · Institute of Aerospace Medical Engineering); Circulating water vacuum pu...

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Abstract

The invention relates to an application of diacerein in relaxation of preshrunk tracheal smooth muscles and preparation of a medicine for treating asthma, which belong to the field of medicines. The in-vitro tracheal ring muscle tension of an experimental mouse is detected, the diacerein has the effect of efficiently relaxing tracheal smooth muscles, especially can relax high-potassium induced airway smooth muscle preconstriction and acetylcholine induced airway smooth muscle preconstriction, and is expected to be applied to relieving the symptom of airway obstruction during attack of asthma patients.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of diacerein (Diacerein) in relaxing and pre-contracting tracheal smooth muscle and treating asthma, which can be used for the development of new drugs for preventing or treating asthma. Background technique [0002] Asthma is a serious chronic respiratory disease and an allergic disease with abnormal immune function, which is a worldwide problem. However, the disease not only has a high incidence rate, but also has a long course of disease and is prone to repeated attacks, which is also a serious public health problem. In recent years, with the in-depth research on genetics, immunology, cytology, biology and molecular biology, the research on the pathogenesis of bronchial asthma has also made unprecedented progress, marking a new step in the prevention and treatment of asthma. new steps. However, the pathogenesis of asthma is extremely complicated, and some m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/222A61P11/06
CPCA61K31/222A61P11/06
Inventor 沈金花时顺波
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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