Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma

A technology of tracheal smooth muscle and diacerein, applied in the field of medicine
CN110787157AInactive Publication Date: 2020-02-14SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Publication Date
2020-02-14
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to an application of diacerein in relaxation of preshrunk tracheal smooth muscles and preparation of a medicine for treating asthma, which belong to the field of medicines. The in-vitro tracheal ring muscle tension of an experimental mouse is detected, the diacerein has the effect of efficiently relaxing tracheal smooth muscles, especially can relax high-potassium induced airway smooth muscle preconstriction and acetylcholine induced airway smooth muscle preconstriction, and is expected to be applied to relieving the symptom of airway obstruction during attack of asthma patients.
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Description

technical field

[0001] The invention belongs to the field of medicine, and specifically relates to the application of diacerein (Diacerein) in relaxing and pre-contracting tracheal smooth muscle and treating asthma, which can be used for the development of new drugs for preventing or treating asthma. Background technique

[0002] Asthma is a serious chronic respiratory disease and an allergic disease with abnormal immune function, which is a worldwide problem. However, the disease not only has a high incidence rate, but also has a long course of disease and is prone to repeated attacks, which is also a serious public health problem. In recent years, with the in-depth research on genetics, immunology, cytology, biology and molecular biology, the research on the pathogenesis of bronchial asthma has also made unprecedented progress, marking a new step in the prevention and treatment of asthma. new steps. However, the pathogenesis of asthma is extremely complicated, and some m...

Claims

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