Application of diclofenac sodium in relaxation of pre-contractive tracheal smooth muscle and asthma treatment

A technology of diclofenac sodium and tracheal smooth muscle, which is applied in the field of medicine to achieve the effects of relieving airway obstruction and efficiently relaxing tracheal smooth muscle

Inactive Publication Date: 2019-04-16
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Diclofenac sodium relaxes airway smooth muscle in the treatment of asthma, and there are no relevant reports at home and abroad.

Method used

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  • Application of diclofenac sodium in relaxation of pre-contractive tracheal smooth muscle and asthma treatment
  • Application of diclofenac sodium in relaxation of pre-contractive tracheal smooth muscle and asthma treatment
  • Application of diclofenac sodium in relaxation of pre-contractive tracheal smooth muscle and asthma treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. In vitro isolation of mouse trachea:

[0040] Six-week-old male adult BALB / c mice were sacrificed by cervical dislocation. The mice were fixed on a dissection board with the abdomen facing up. The thoracic cavity was cut to expose the heart and lung tissue. A whole section of tissue from the upper part was immersed in PSS solution (NaCl 135mM, KCl 5mM, MgCl) throughout the experiment 2 1mM, CaCl 2 2 mM, HEPES 10 mM, glucose 10 mM, adjusted to pH 7.4 with 5 mM NaOH solution), then the isolated tissue was fixed on an organic rubber plate with a diameter of 8 cm and a thickness of 1 cm, and carefully removed with Venus scissors under a stereo microscope The connective tissue around the trachea and the residual blood in the lumen are separated from the main tracheal ring of about 5-7mm.

[0041] 2. Tension detection method of mouse airway smooth muscle:

[0042]The isolated mouse trachea was cut into a tracheal ring with a length of about 5 mm and then connected to th...

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PUM

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Abstract

The invention relates to application of diclofenac sodium in relaxation of pre-contractive tracheal smooth muscle and preparation of asthma treatment drugs and belongs to the field of medicine. It isfound through tests that diclofenac sodium has the great effect on relaxing the pre-contractive tracheal smooth muscle. The diclofenac sodium can make the relaxation percentage of the pre-contractivetracheal smooth muscle caused by high potassium reach 80.02+/-2.123% and make the relaxation percentage of pre-contractive tracheal smooth muscle caused by ACh reach 95+/-1.528%. In addition, the diclofenac sodium can be utilized to relax the pre-contractive tracheal smooth muscle, and it is indicated that the diclofenac sodium is expected to be developed as a new drug for asthma treatment.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of Diclofenac sodium in tracheal smooth muscle used for relaxation and pre-contraction, which can be used for the development of new drugs for treating asthma. Background technique [0002] Asthma is composed of a variety of cells including airway inflammatory cells and structural cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, airway epithelial cells, etc.) and cellular elements ) involved in chronic inflammatory diseases of the airways. This chronic inflammation results in airway hyperresponsiveness, usually with widely variable and reversible airflow limitation, and causes recurrent episodes of wheezing, shortness of breath, chest tightness, or coughing, often onset, exacerbated at night and / or early in the morning. , most patients can relieve spontaneously or after treatment. The risk factors of asthma include host factors (ge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61P11/06
CPCA61K31/196A61P11/06
Inventor 沈金花陈春发
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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