46 results about "Airway smooth muscle" patented technology

Methods of increasing gas exchange performed by the lung by damaging lung cells, damaging tissue, causing trauma, and / or destroying airway smooth muscle tone with an apparatus inserted into an airway of the lung. The damaging of lung cells, damaging tissue, causing trauma, and destroying airway smooth muscle tone with the apparatus may be any one of or combinations of the following: heating the airway; cooling the airway; delivering a liquid to the airway; delivering a gas to the airway; puncturing the airway; tearing the airway; cutting the airway; applying ultrasound to the airway; and applying ionizing radiation to the airway.

The invention provides an artemisia apiacea extract. The artemisia apiacea extract is prepared by the following steps: selecting dry artemisia apiacea as a raw material and grinding the artemisia apiacea into powder; heating the powder by using deionized water at 50-60 DEG C for 3h, vibrating once per 15min, filtering and collecting filtrate; repeatedly extracting filter residues once; merging the filtrate; evaporating to dryness by using a rotary evaporator and collecting residues; dissolving the residues into the deionized water, extracting the solution by using isopyknic petroleum ether for 2-4h, removing grease and other petroleum ether-soluble materials and collecting percolate; and extracting by using isopyknic chloroform, collecting an extract liquid, evaporating to dryness and preparing paste, namely the artemisia apiacea chloroform extract. An experiment shows that the extract is capable of relaxing airway smooth muscle and can be used for relieving airway obstruction of an asthma patient, so that the artemisia apiacea chloroform extract can be applied to preparation of medicines for treating bronchial asthma.

The invention provides a lotus plumule chloroform extract. The lotus plumule chloroform extract is prepared by adopting the following steps: selecting dry lotus plumule as a raw material, and grinding into powder; adopting methyl alcohol or ethyl alcohol to carry out heating reflux extraction two to four times, and collecting an extract; carrying out centrifugal treatment on the extract, collecting supernatant, then evaporating the supernatant to dryness by using a rotary evaporator, and collecting residues; dissolving the residues to a hydrochloric acid solution, extracting two to four times by using petroleum ether, removing oils and fats, and collecting a filtrate; adjusting the pH value of the filtrate to be 9-11, then extracting by using chloroform, collecting an extract liquor and evaporating to obtain an extract, namely the lotus plumule chloroform extract. Experiments show that the extract can relax airway smooth muscle, and can be used for relieving the airway obstruction of an asthma patient, so that the lotus plumule chloroform extract can be applied to the preparation of medicine for treating bronchial asthma.

The present invention relates to a composition for preventing, alleviating or treating respiratory diseases, containing a Siraitia grosvenorii residual extract as an active ingredient. In an ovalbumin(OVA) induced asthma animal model, a Siraitia grosvenorii residual extract of the present invention has effects of reducing airway hypersensitivity, inhibiting inflammatory cells in bronchoalveolar lavage fluid and reducing Th2 cytokines (IL-4, IL-5 and IL-13) in bronchoalveolar lavage fluid, reducing inflammation and tissue damage in lung tissue, inhibiting airway smooth muscle contraction and airway inflammation, inhibiting the expression of IL-13, TARC, TNF-a, IL-17 and mucus gene MUC5AC in lung tissue, and reducing, in alveolar cells, ROS having increased because of fine dust.