46 results about "Airway smooth muscle" patented technology

The invention relates to a pharmaceutical composition for treating chronic bronchitis. The pharmaceutical composition for treating chronic bronchitis is prepared from the following components according to a shown weight part ratio range: 40-60 parts of aster, 40-60 parts of dandelion, 25-35 parts of phoenix-tail fern, 25-35 parts of radix tinosporae, 20-30 parts of bulbus fritillariae cirrhosae, 10-20 parts of dysosma versipellis, 10-20 parts of common andrographis herb, 10-20 parts of isatis root, 3-8 parts of herba lagotis, 3-8 parts of borneol and 3-8 parts of radix ophiopogonis. According to the pharmaceutical composition, all Chinese medicinal herbs are compatible, monarch and minister are cooperated, and assistant and guide are assisted, so that the pharmaceutical composition has the functions of carrying out desensitization and adjusting vegetative nerve imbalance, has the function of directly expanding airway smooth muscle, and is capable of relieving bronchus smooth muscle spasm to ensure that a subcutaneous nodule and epithelial cells of neutral cells are reduced and the cellular degeneration is lightened so that the virus toxicity is remarkably weakened. The pharmaceutical composition has a capacity of improving body defence, and lesion repair is promoted, the symptoms such as cough, phlegm, asthma and lung wheezing rale are remarkably relieved.

The invention discloses a novel method for lowering the breath resistance of the bronchus, which achieves the aim of treating asthma by the function of suppressing MLCK and still belongs to the first time at home and even abroad. The preparation of an MLCK gene knockout mouse and the research of the contraction function of the MLCK gene knockout mouse confirm the key function of the MLCK in the contraction of the smooth muscle of the air duct so as to confirm that the breath resistance of the bronchus can be obviously lowered under the conditions of physiology and pathology by suppressing the MLCK, thereby making a sufficient preparation for the next artificial synthesis of an MLCK suppressor used for treating the asthma. The invention not only finds the novel method for lowering the breath resistance of the bronchus but also provides a concept for developing other treatment schemes afterwards.

The invention discloses application of artemisinin and artesunate as an artemisinin derivative to preparation of a medicine for treating asthma and belongs to the field of biological medicine. The artemisinin and the artesunate as the artemisinin derivative have a remarkable effect of inhibiting the asthma, and are specifically capable of inhibiting the proliferation of smooth muscle cells and promoting apoptosis to inhibit the reconstruction of an asthmatic airway, capable of inhibiting the smooth muscle cells from synthesizing and secreting inflammatory factors TGF-beta1, IL-5 and IL-8 to relieve the inflammation of the asthmatic airway, and also capable of inhibiting the proliferation of airway smooth muscle, promoting the apoptosis and relieving the reconstruction of the airway. The artemisinin and the artesunate as the artemisinin derivativ are capable of effectively inhibiting the inflammation of the airway and relieving the reconstruction of the airway in the genesis and development of the asthma so as to achieve a good treatment effect on the asthma. The known artemisinin and the derivative artesunate are used for preparing the medicine for treating the asthma, a new application field is created, and remarkable economic and social benefits are brought.

The invention provides a method for preparing sedum sarmentosum extract and use thereof for preparing medicine for relaxing airway smooth muscle. The sedum sarmentosum extract includes at least one ofan ethanol extract of sedum sarmentosum, a petroleum ether extract of sedum sarmentosum, an ethyl acetate extract of sedum sarmentosum, a n-butanol extract of sedum sarmentosum, and a residual water-phase concentrate after extraction and separation. In the present application, through the detection of isolated tracheal ring muscle tension in experimental mice and Ca<2+> detection in airway smoothmuscle cells, the sedum sarmentosum extract is a highly effective drug for relaxing airway smooth muscle, and the relaxation is caused by blocking LVDCCs and activating calcium channels such as BKCa.The above research results can confirm that sedum sarmentosum extract has the ability to relieve airway obstruction of asthma patients and can be used in the preparation of drugs for relaxing airwaysmooth muscle.

The invention provides a lotus plumule chloroform extract. The lotus plumule chloroform extract is prepared by adopting the following steps: selecting dry lotus plumule as a raw material, and grinding into powder; adopting methyl alcohol or ethyl alcohol to carry out heating reflux extraction two to four times, and collecting an extract; carrying out centrifugal treatment on the extract, collecting supernatant, then evaporating the supernatant to dryness by using a rotary evaporator, and collecting residues; dissolving the residues to a hydrochloric acid solution, extracting two to four times by using petroleum ether, removing oils and fats, and collecting a filtrate; adjusting the pH value of the filtrate to be 9-11, then extracting by using chloroform, collecting an extract liquor and evaporating to obtain an extract, namely the lotus plumule chloroform extract. Experiments show that the extract can relax airway smooth muscle, and can be used for relieving the airway obstruction of an asthma patient, so that the lotus plumule chloroform extract can be applied to the preparation of medicine for treating bronchial asthma.

The invention discloses an application of a safflower organic solvent part extract in preparation of airway smooth muscle relaxation medicines. Research discovers that the safflower is capable of causing the relaxation of contractive airway smooth muscle, has a relaxation effect about three times higher than that of beta2 receptor stimulant isoprenaline clinically used at present, and can be applied to preventing and/or treating asthma. In addition, the detection on the cyclic tension of the isolated organ of an experimental rat also proves that the safflower organic solvent part extract has an effective airway smooth muscle relaxation effect and can be applied to relieving the airway obstruction; in short, a high-efficiency new medicinal source is provided for preventing and treating the asthma.

The invention relates to a novel method for preventing and treating asthma, in particular to a pertussis vaccine for preventing and treating asthma through oral immunological tolerance. As proved by experiments, the pertussis vaccine with low oral dosage can achieve the aim of preventing and treating asthma. The method not only applies the pertussis vaccine to prevention and treatment of asthma for the first time but also is convenient to apply medicines and prolongs the treatment effect in a mode of oral application according to the theory of 'oral tolerance'. The method breaks through the prior method for treating asthma by taking 'anti-inflammation, relaxation of smooth muscles in the air passage' as targets, establishes a novel path which 'gives priority to asthma prevention', and then develops a novel path for controlling attack and preventing asthma.

The invention relates to the field of a protein drug, and particularly discloses novel use of S100 calcium binding protein A11 for preparation of a drug for relaxing airway smooth muscle, and a drug preparation containing the protein. The invention discloses a novel function of the S100 calcium binding protein A11 for relaxing the airway smooth muscle. The airway smooth muscle can be obviously relaxed by the S100A11; the airway resistance of an asthma model rat is reduced, so as to play a role of treatment of asthma. The S100 calcium binding protein A11 can be applied to treatment of an asthma disease and preparation of a drug for treating asthma, and is applied to the quality of the asthma disease in a form of an injection or spray. Therefore, the S100 calcium binding protein A11 has the advantages of being safe, effective and stable to use and the like.

The invention discloses application of dandelion or dandelion extractive in preparation of airway smooth muscle shrinking restrainer. Research finds that dandelion, particularly ethyl acetate extractive can relax airway smooth muscle, relieve airway obstruction of an asthma patient, and be used for preparing medicine preventing or curing bronchial asthma.

The present invention relates to extracts of Sophora Flavascens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavascens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.

The invention relates to the field of a protein medicine, and in particular discloses application of S100 calcium binding protein A8 in preparation of an airway smooth muscle dilating medicine and a pharmaceutical preparation containing the protein. The invention discloses a new function of S100 calcium binding protein A8 for dilating airway smooth muscle; S100A8 can significantly dilate the airway smooth muscle and reduce airway resistance of an asthma model rat so as to treat asthma; S100A8 is applicable to treatment of asthma disease and preparation of an asthma treating medicine; S100A8 is used for treating the asthma disease in a form of injection or spray, and is safe to use, effective and stable.

The invention discloses application of an extract of cynanchum stauntonii in the preparation of drugs for relaxing the airway smooth muscle. The tension of the isolated tracheal circular muscle of anexperimental mouse is detected, the extract of the cynanchum stauntonii relaxes pre-contraction of the airway smooth muscle induced by acetyl choline and potassium, and it is found that the extract ofthe cynanchum stauntonii is a highly effective drug for relaxing the airway smooth muscle; and it is found that ethyl acetate extract (EAEC) of the cynanchum stauntonii can block other channels except for a VDCCs channel to participate in the relaxation of tracheal smooth muscle; and the VDCCs channel is excluded, the ethyl acetate extract of cynanchum stauntonii can block other channels except for VDCCs and NSCCs to participate the relaxation of the airway smooth muscle.

The invention discloses application of an extract from sophora alopecuroides in preparation of medicines for relaxing the airway smooth muscle. Detection on the muscle tension of tracheal rings isolated from a laboratory mouse discovers that the extract from sophora alopecuroides is a medicinal material with an efficient effect for relaxing the airway smooth muscle, which indicates that sophora alopecuroides is a source for new efficient medicines for preventing and treating asthma. The extract from sophora alopecuroides can be used for relieving the symptom of airway obstruction when an asthma patient is attacked, and has a great popularization value.

The invention provides a novel medicine for preventing and treating asthma, which is Bordetella pertussis CpG-ODNs (CpG oligodeoxynucleotides) with a sequence as shown by SEQIDNO.1. The Bordetella pertussis CpG-ODNs (seqA) can inhibit inflammatory response of the asthma and prevent or control asthmatic attack. With generation of signal transduction by using a TLR-9 (Toll-like Receptor) signal molecule and Th1/Th2 (T helper 1/ T helper 2) unbalance as theoretical basis, effects of the seqA on adjustments of asthma related cell factors and inhibition of airway inflammation are found in the invention. The invention breaks through a traditional asthma treatment method of using inflammation prevention and relaxation of an airway smooth muscle as a target point and establishes a new way with asthma control as main, thereby building up a new way for controlling asthmatic attack and preventing the asthma.

Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

The present invention relates to the field of drug research and development, and specifically discloses uses of an actin binding protein 2 in smooth muscle dysfunction disease treatment drug screening. According to the present invention, Transgelin2 is adopted as a drug action target protein, 22 possible micromolecule compounds are designed and initially screened, and 2 micromolecule drugs with the exact airway smooth muscle relaxation function are screened from the 22 possible micromolecule compounds through the further cell experiments so as to be used for the preparation of the airway smooth muscle relaxation drugs; and the guidance and the reference are provided for the application of the Transgelin2 protein in the treatment of a plurality of diseases possibly caused by smooth muscle dysfunction and including vascular smooth muscle spasm diseases, intestinal canal smooth muscle spasm diseases, trachea smooth muscle spasm diseases, and endocrine diseases.

The present disclosure relates to methods for relaxing airway smooth muscle tissue, alleviating or preventing bronchospasm, and treating lung diseases by administering an HMG-CoA reductase inhibitor (statin) directly to lung tissue by inhalation. The disclosure also relates to formulations and compositions useful for the practice of methods of the disclosure.

The invention discloses the application of a rhizoma alismatis extract in the preparation of a drug for relaxing the airway smooth muscle. It is found that the rhizoma alismatis extract has an efficient function of relaxing the airway smooth muscle through the detection of the isolated tracheal ring muscle tension of an experimental mouse, can be used for alleviating the symptom of airway obstruction during asthmatic attack of a patient, and has great promotion value.