Application of whitewashine in the preparation of medicines for relaxation and pre-contraction of tracheal smooth muscle

A technique for tracheal smooth muscle and airway smooth muscle, which is applied in the field of medicine to achieve the effect of efficiently relaxing tracheal smooth muscle

Inactive Publication Date: 2020-12-22
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
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Problems solved by technology

Recent studies have shown that cisternine is cytotoxic to human cervical cancer, colon cancer and oral cancer cells, but it has never been used in drugs that relax airway smooth muscle in the treatment of asthma

Method used

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  • Application of whitewashine in the preparation of medicines for relaxation and pre-contraction of tracheal smooth muscle
  • Application of whitewashine in the preparation of medicines for relaxation and pre-contraction of tracheal smooth muscle

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Embodiment Construction

[0014] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, and the content of the present invention is not limited to the following embodiments.

[0015] In vitro isolation of mouse trachea:

[0016] Male BABL / C mice aged 6-8 weeks were sacrificed by neck dissection, and the abdomen of the mouse was fixed on the dissecting board. The chest cavity was cut open to expose the heart and lung tissue. For the whole tissue, immediately soak the removed tissue in pre-cooled PSS solution (NaCl 135mM, KCl 5mM, MgCl 2 1mM, CaCl 2 2mM, HEPES 10mM, glucose 10mM, NaOH to adjust the pH to 7.4), and then transferred to the gel plate to further separate the tracheal ring. Under a stereomicroscope, use Venus scissors to carefully remove the connective tissue around the trachea and the residual blood in the lumen, and separate the main tracheal ring of about 5-7mm.

[0017] Tension detection method of mouse airway smooth mus...

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Abstract

The invention relates to the technical field of medicine, in particular to an application of dictamnine to preparation of a medicine for relaxing precontracted tracheal smooth muscles. The action mechanism of the dictamnine in the aspect of relaxing the pre-stimulated airway smooth muscle is found, particularly, the dictamnine has a relaxing effect on contraction of the airway smooth muscle induced by high potassium and acetylcholine, and a basis is provided for developing the dictamnine for relaxing the airway smooth muscle to prepare the medicine for treating asthma.

Description

technical field [0001] The invention relates to the technical field of medical technology, in particular to the application of catharonine in the preparation of medicaments for relaxing and pre-contracting tracheal smooth muscle. Background technique [0002] Asthma, also known as bronchial asthma, is an airway inflammatory disease involving eosinophils and other inflammatory cells and cytokines. Sustained contraction of airway smooth muscle and increased calcium sensitivity are one of the main symptoms of asthma and chronic obstructive pulmonary disease. Among the above drugs for the treatment of respiratory diseases, bronchodilator drugs such as glucocorticoids are common clinical drugs. In recent years, various new treatments and drugs for the treatment of asthma have emerged, but there is still no effective drug that can completely cure asthma. Therefore, it is still necessary to develop small molecular compounds that can relax and pre-shrink airway smooth muscle as new...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/438A61P11/06
CPCA61K31/438A61P11/06
Inventor 沈金花韩淑慧
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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