Application of rauvolfia verticillate ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle

A technology for extracting tracheal smooth muscle and ethanol, which is applied in the field of medicine, can solve problems such as the treatment of asthma that have not yet been seen, and achieve the effect of efficiently relaxing tracheal smooth muscle

Active Publication Date: 2021-05-07
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, there is no report on the use of Rauwolfia to relax tracheal smooth muscle and then treat asthma

Method used

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  • Application of rauvolfia verticillate ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle
  • Application of rauvolfia verticillate ethanol extract to preparation of medicine for relaxing preshrunk tracheal smooth muscle

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Embodiment Construction

[0015] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, and the content of the present invention is not limited to the following embodiments.

[0016] 1. Preparation of Rauwolfia ethanol extract:

[0017] The dried root of Rauwolfia is used as raw material, and it is ground into a powder state. Take 500g of Rauwolfia powder, soak it in 95% ethanol solution at room temperature for 4 days with a solid-to-liquid ratio of 1:10. The soaked solution is filtered and then rotary evaporated to obtain the ethanol extract, which is the ethanol extract of Rauwolfia, which is placed in a vacuum drying oven for later use. During the experiment, dimethyl sulfoxide (DMSO) was used as a solvent to dissolve the ethanol extract of Rauwolfia for biological activity experiments.

[0018] 2. In Vitro Isolation of Mouse Trachea

[0019] The animals used in the experiments were male BALB / c mice aged 6-8 weeks. After the mice we...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a rauvolfia verticillate ethanol extract to preparation of a medicine for relaxing preshrunk tracheal smooth muscle. According to the invention, test on the in-vitro tracheal ring muscle tension of an experimental mouse discovers that the rauvolfia verticillate ethanol extract has efficient effect of relaxing tracheal smooth muscle, and the substance is expected to be used for relieving asthma. A basis is provided for developing the application of the rauvolfia verticillate ethanol extract to preparation of the medicine for relaxing the preshrunk tracheal smooth muscle.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of the ethanol extract of Rauwolfia in the preparation of medicine for relaxing and pre-contracting tracheal smooth muscle. Background technique [0002] The full name of asthma is bronchial asthma, which is jointly participated by structural cells, inflammatory cells, and cell components. Asthma is clinically manifested as paroxysmal dyspnea, shortness of breath, chest tightness, cough, etc., usually accompanied by wheezing. Some data show that the development of social industry has led to worsening air quality and an increase in the content of harmful substances in the air, which in turn has led to a significant increase in asthma cases. Traditional Chinese medicine has the advantages of long research history, low price, mild effect, and not easy to produce drug resistance. We use this as a research idea to find safe and effective drugs for the treatment of as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/24A61P11/06
CPCA61K36/24A61P11/06A61K2236/333Y02A50/30
Inventor 沈金花李威
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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