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Application of Rauwolfia Ethanol Extract in Preparation of Tracheal Smooth Muscle Medicine for Relaxation and Pre-contraction

A technology for extracting tracheal smooth muscle and ethanol, which is applied in the field of medicine, can solve problems such as the treatment of asthma that have not yet been seen, and achieve the effect of efficiently relaxing tracheal smooth muscle

Active Publication Date: 2022-06-07
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of Rauwolfia to relax tracheal smooth muscle and then treat asthma

Method used

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  • Application of Rauwolfia Ethanol Extract in Preparation of Tracheal Smooth Muscle Medicine for Relaxation and Pre-contraction
  • Application of Rauwolfia Ethanol Extract in Preparation of Tracheal Smooth Muscle Medicine for Relaxation and Pre-contraction

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Embodiment Construction

[0015] The present invention is described in detail in detail in conjunction with the accompanying drawings and embodiments below, the content of the present invention is not limited to the following embodiments.

[0016] 1. Preparation of rawwood ethanol extract:

[0017] The dried roots of ravenwood are used as raw materials and ground to form a powder. Take 500g of ravenwood powder and soak in 95% ethanol solution at room temperature at a solid-liquid ratio of 1:10 for 4 days. The soaked solution is filtered and then rotated to evaporate to obtain ethanol extract, that is, rawwood ethanol extract, which is placed in a vacuum drying box for later use. During the experiment, dissolve the olamine extract of radha viol with dimethyl sulfoxide (DMSO) as a solvent for biological activity experiments.

[0018] 2. In vitro isolation of mouse trachea

[0019] The animals used in the experiment were male BALB / c mice aged 6-8 weeks. Mice are sacrificed by the neck-breaking method and fixe...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of the ethanol extract of Rauwolfia in the preparation of medicine for relaxing and pre-contracting tracheal smooth muscle. The present invention finds that the ethanol extract of Rauwolfia ethanol has an efficient effect of relaxing tracheal smooth muscle through the detection of muscle tension of the isolated tracheal ring of experimental mice, suggesting that the substance is expected to be used for alleviating asthma. It provides a basis for the development of the application of the ethanol extract of Rauwolfia in the preparation of drugs for relaxing pre-contracted tracheal smooth muscle.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical technology, in particular to the application of radha ethanol extract in the preparation of drugs for diastolic pre-contraction of tracheal smooth muscle. Background [0002] Asthma, also known as bronchial asthma, is involved in structural cells, inflammatory cells, and cellular components. Asthma is clinically characterized by episodic dyspnea, shortness of breath, chest tightness, cough, etc., and is usually accompanied by wheezing. Data show that the development of social industry has led to poor air quality and an increase in the content of harmful substances in the air, which in turn has led to a significant increase in asthma cases. Traditional Chinese medicine has the advantages of a long research history, low price, mild effect, and difficulty in developing drug resistance, so as to use this as a research idea to find safe and effective drugs for the treatment of asthma. [0003] Luofu wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/24A61P11/06
CPCA61K36/24A61P11/06A61K2236/333Y02A50/30
Inventor 沈金花李威
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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