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Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma

A technology of artesunate and derivatives, applied in the field of biomedicine, can solve the problems of large side effects and unsatisfactory effects, and achieve the effect of suppressing asthma and significant economic and social benefits

Inactive Publication Date: 2015-07-22
AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of large side effects and unsatisfactory effects of asthma treatment drugs in the prior art, and to provide an application of artemisinin and its derivative artesunate in the preparation of drugs for the treatment of asthma

Method used

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  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma
  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma
  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma

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Experimental program
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Embodiment 1

[0024] (1) Isolation and culture of primary asthmatic rat airway smooth muscle cells (ASMCs)

[0025] Take the 3rd to 4th grade bronchi of SD rats with asthma, peel off the pulmonary artery, pulmonary vein, nerve fiber, connective tissue, etc. Transfer to D-Hank's solution containing collagenase, papain, and bovine serum albumin, and place in 37°C with a volume concentration of 5% CO 2 Digest in an incubator for 40-50 minutes, filter with a 100-mesh stainless steel mesh, centrifuge at 800 rpm, remove the supernatant, add 20% fetal bovine serum in DMEM to suspend the separated single cells, and plant in a 25ml culture bottle in 5% CO at 37°C 2 Cultured in an incubator; after the primary cells grew and fused, they were digested and subcultured with 0.25% trypsin, and subcultured with DMEM medium containing 10% fetal bovine serum, and the 4th to 10th generation cells were used for experiments. Rat airway smooth muscle cells (ASMCs) figure 1 shown.

[0026] (2) Effect of artes...

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Abstract

The invention discloses application of artemisinin and artesunate as an artemisinin derivative to preparation of a medicine for treating asthma and belongs to the field of biological medicine. The artemisinin and the artesunate as the artemisinin derivative have a remarkable effect of inhibiting the asthma, and are specifically capable of inhibiting the proliferation of smooth muscle cells and promoting apoptosis to inhibit the reconstruction of an asthmatic airway, capable of inhibiting the smooth muscle cells from synthesizing and secreting inflammatory factors TGF-beta1, IL-5 and IL-8 to relieve the inflammation of the asthmatic airway, and also capable of inhibiting the proliferation of airway smooth muscle, promoting the apoptosis and relieving the reconstruction of the airway. The artemisinin and the artesunate as the artemisinin derivativ are capable of effectively inhibiting the inflammation of the airway and relieving the reconstruction of the airway in the genesis and development of the asthma so as to achieve a good treatment effect on the asthma. The known artemisinin and the derivative artesunate are used for preparing the medicine for treating the asthma, a new application field is created, and remarkable economic and social benefits are brought.

Description

technical field [0001] The invention relates to the application of artemisinin and its derivative artesunate, in particular to the application of artemisinin and its derivative artesunate in preparing medicine for treating asthma, and belongs to the field of biomedicine. Background technique [0002] Bronchial asthma (Asthma for short) is a chronic airway inflammatory disease involving various cytokines, and its characteristic pathological changes are airway inflammation and airway remodeling. In recent years, airway inflammation and airway remodeling have become the focus of research in the pathogenesis and treatment of bronchial asthma. [0003] At present, foreign research focuses on culturing various normal airway smooth muscle cells (ASMCs) in vitro, and studies the effects of various inflammatory mediators, growth factors, and cytokines related to asthma on the proliferation of normal ASMCs. However, due to the differences in the phenotype and functional status of nor...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/357A61P11/06
Inventor 莫碧文韦江红莫弼凡王昌明曾锦荣黄剑伟王绩英蒋明
Owner AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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