Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma

A technology of artesunate and derivatives, applied in the field of biomedicine, can solve the problems of large side effects and unsatisfactory effects, and achieve the effect of suppressing asthma and significant economic and social benefits

Inactive Publication Date: 2015-07-22
AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of large side effects and unsatisfactory effects of asthma treatment drugs in

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma
  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma
  • Application of artemisinin and artesunate as artemisinin derivative to preparation of medicine for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Isolation and culture of primary asthmatic rat airway smooth muscle cells (ASMCs)

[0025] Take the 3rd to 4th grade bronchi of SD rats with asthma, peel off the pulmonary artery, pulmonary vein, nerve fiber, connective tissue, etc. Transfer to D-Hank's solution containing collagenase, papain, and bovine serum albumin, and place in 37°C with a volume concentration of 5% CO 2 Digest in an incubator for 40-50 minutes, filter with a 100-mesh stainless steel mesh, centrifuge at 800 rpm, remove the supernatant, add 20% fetal bovine serum in DMEM to suspend the separated single cells, and plant in a 25ml culture bottle in 5% CO at 37°C 2 Cultured in an incubator; after the primary cells grew and fused, they were digested and subcultured with 0.25% trypsin, and subcultured with DMEM medium containing 10% fetal bovine serum, and the 4th to 10th generation cells were used for experiments. Rat airway smooth muscle cells (ASMCs) figure 1 shown.

[0026] (2) Effect of artes...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses application of artemisinin and artesunate as an artemisinin derivative to preparation of a medicine for treating asthma and belongs to the field of biological medicine. The artemisinin and the artesunate as the artemisinin derivative have a remarkable effect of inhibiting the asthma, and are specifically capable of inhibiting the proliferation of smooth muscle cells and promoting apoptosis to inhibit the reconstruction of an asthmatic airway, capable of inhibiting the smooth muscle cells from synthesizing and secreting inflammatory factors TGF-beta1, IL-5 and IL-8 to relieve the inflammation of the asthmatic airway, and also capable of inhibiting the proliferation of airway smooth muscle, promoting the apoptosis and relieving the reconstruction of the airway. The artemisinin and the artesunate as the artemisinin derivativ are capable of effectively inhibiting the inflammation of the airway and relieving the reconstruction of the airway in the genesis and development of the asthma so as to achieve a good treatment effect on the asthma. The known artemisinin and the derivative artesunate are used for preparing the medicine for treating the asthma, a new application field is created, and remarkable economic and social benefits are brought.

Description

technical field [0001] The invention relates to the application of artemisinin and its derivative artesunate, in particular to the application of artemisinin and its derivative artesunate in preparing medicine for treating asthma, and belongs to the field of biomedicine. Background technique [0002] Bronchial asthma (Asthma for short) is a chronic airway inflammatory disease involving various cytokines, and its characteristic pathological changes are airway inflammation and airway remodeling. In recent years, airway inflammation and airway remodeling have become the focus of research in the pathogenesis and treatment of bronchial asthma. [0003] At present, foreign research focuses on culturing various normal airway smooth muscle cells (ASMCs) in vitro, and studies the effects of various inflammatory mediators, growth factors, and cytokines related to asthma on the proliferation of normal ASMCs. However, due to the differences in the phenotype and functional status of nor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/366A61K31/357A61P11/06
Inventor 莫碧文韦江红莫弼凡王昌明曾锦荣黄剑伟王绩英蒋明
Owner AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap