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Application of dandelion or dandelion extractive in preparation of airway smooth muscle shrinking restrainer

An airway smooth muscle and contraction inhibitor technology is applied to the application field of dandelion or its extract in the preparation of an airway smooth muscle contraction inhibitor, and can solve the problem of limited therapeutic effect, easy recurrence of the disease, increased social and economic burden and loss, etc. To achieve the effect of relieving airway hyperresponsiveness and effective relaxation

Inactive Publication Date: 2015-04-29
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, bronchodilators such as β2-receptor agonists are widely used clinically, but the therapeutic effect is limited. 30-45% of patients’ asthma symptoms cannot be controlled.
This causes great suffering to the patients themselves and their families, and also seriously increases the social and economic burden and loss

Method used

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  • Application of dandelion or dandelion extractive in preparation of airway smooth muscle shrinking restrainer
  • Application of dandelion or dandelion extractive in preparation of airway smooth muscle shrinking restrainer

Examples

Experimental program
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Embodiment 1

[0021] 1, the preparation of dandelion ethyl acetate extract:

[0022] Dandelion was purchased from Tong Ren Tang. Select dried whole dandelion herb as raw material, grind it into powder; use 75% ethanol to heat and reflux extract three times, and collect the extract; centrifuge the extract, collect the supernatant, and then evaporate the supernatant to dryness with a rotary evaporator , collect the residue; the residue is dissolved in 2% hydrochloric acid solution, extracted 3 times with sherwood oil, removes grease, and collects the filtrate; adjusts the pH value of the filtrate to 10 with ammonia water, and then uses Ethyl acetate extraction, the extract is collected and evaporated to dryness to obtain an extract, that is, the ethyl acetate extract of dandelion, which is about 0.5% of the dry weight of the raw material. Dandelion ethyl acetate extract was dissolved in DMSO for biological activity test.

[0023] 2. In vitro isolation of mouse trachea:

[0024] Male adult ...

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Abstract

The invention discloses application of dandelion or dandelion extractive in preparation of airway smooth muscle shrinking restrainer. Research finds that dandelion, particularly ethyl acetate extractive can relax airway smooth muscle, relieve airway obstruction of an asthma patient, and be used for preparing medicine preventing or curing bronchial asthma.

Description

technical field [0001] The invention relates to a new application of dandelion or its extract, in particular to the application of dandelion or its extract in the preparation of airway smooth muscle contraction inhibitor. Background technique [0002] In recent years, the rapid development of my country's industry has brought economic prosperity, but it has also inevitably led to large-scale air pollution in many cities. Along with the increasingly frequent occurrence of severe weather such as smog, smog-induced bronchial asthma (hereinafter "Asthma" for short) and other respiratory diseases, the visit rate of patients with respiratory diseases has doubled, and this disease is showing a trend of massive outbreaks. At the same time, the development of social economy and the improvement of living standards, the acceleration of environmental changes, and the increasing number of allergens such as automobile exhaust, industrial waste gas, home decoration, food additives, and dome...

Claims

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Application Information

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IPC IPC(8): A61K36/288A61P11/00A61P11/06
Inventor 刘庆华马立群谈丽
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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