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Method for preventing and treating asthma

A kind of asthma, said technology, applied in the field of oral immune tolerance pathway, can solve the problems of insurvivability, reduced vaccine antigenicity, limited intestinal absorption rate, etc., and achieve the effect of convenient administration and long-lasting curative effect

Inactive Publication Date: 2009-07-22
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although oral vaccines have the above advantages, not all vaccines are suitable for oral administration. Many vaccines have many problems when they are taken orally, such as limited absorption rate in the intestinal tract, inability to survive on the mucosal surface, and adverse effects on the digestive tract after oral administration. The antigenicity reduction caused by the inactivation of the vaccine, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] 1. Preparation of B. pertussis vaccine

[0016] The pertussis strains used in this test were purchased from China National Institute for the Control of Pharmaceutical and Biological Products (strain number: 58004), and cultured at 37°C. Pertussis bacteria in the logarithmic growth phase were collected and inactivated at an appropriate temperature to prepare a certain concentration of whole-cell pertussis vaccine.

[0017] 2. Acute toxicity test

[0018] Sixty Balb / c mice, half male and half male, were fed with different doses of inactivated whole-cell vaccine for acute toxicity testing. Preliminary test results, mice were given 10 7 -10 12 After a number of whole-cell bacteria, there was no abnormal behavior or death. showed that mice were given a single dose of 10 12 Pertussis bacterial vaccines of one per mouse or less will not cause death in mice and are safe.

[0019] 3. Establishment of asthma model

[0020] The Balb / c female mice were sensitized with ovalbu...

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PUM

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Abstract

The invention relates to a novel method for preventing and treating asthma, in particular to a pertussis vaccine for preventing and treating asthma through oral immunological tolerance. As proved by experiments, the pertussis vaccine with low oral dosage can achieve the aim of preventing and treating asthma. The method not only applies the pertussis vaccine to prevention and treatment of asthma for the first time but also is convenient to apply medicines and prolongs the treatment effect in a mode of oral application according to the theory of 'oral tolerance'. The method breaks through the prior method for treating asthma by taking 'anti-inflammation, relaxation of smooth muscles in the air passage' as targets, establishes a novel path which 'gives priority to asthma prevention', and then develops a novel path for controlling attack and preventing asthma.

Description

technical field [0001] The invention relates to a new method for preventing and treating asthma, and specifically discloses an oral immune tolerance approach through which pertussis vaccines can prevent and treat asthma. Background technique [0002] Asthma is a common allergic respiratory disease that seriously endangers people's health. Beta-receptor agonists and glucocorticoids are currently the first-line drugs for the treatment of asthma, and are mainly used for the control of asthma symptoms and persistent state or the rescue of critical attacks. However, due to problems such as adverse reactions or drug resistance, there are many limitations in the application process. [0003] Oral tolerance is a type of mucosal tolerance. It refers to the oral administration of a certain food protein or bacterial antigen, which leads to the specific immunity of the local gut-associated lymphoid tissue, thereby suppressing the systemic immune response, which is a specific self-tole...

Claims

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Application Information

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IPC IPC(8): A61K39/10A61P11/06
Inventor 孙云王德俊迟深张宝袁
Owner YANGZHOU UNIV
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