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Artemisia apiacea chloroform extract and preparation method and application thereof

A technology of extract and chloroform, applied in the field of medicines for the preparation and treatment of bronchial asthma by the chloroform extract of Artemisia annua

Inactive Publication Date: 2017-05-31
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, although there are related literature reports that artemisinin and its derivative artesunate have the effect of preparing asthma medicine, the component that exerts the effect is artemisinin, and there is no other compound in Artemisia annua except artemisinin. Reports on the effectiveness of treating asthma

Method used

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  • Artemisia apiacea chloroform extract and preparation method and application thereof
  • Artemisia apiacea chloroform extract and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0022] The preparation method of Artemisia annua chloroform extract in the present embodiment is as follows:

[0023] Select dried Artemisia annua as raw material, grind it into powder; soak it in deionized water (pH: 9), heat at 52°C for 3 hours, repeat 3 times, and collect the extract; evaporate the extract to dryness with a rotary evaporator, and collect the residual The residue was dissolved in 200 milliliters of deionized water (pH: 9), extracted three times with an equal volume of petroleum ether to remove grease and other petroleum ether soluble substances, and the filtrate was collected; the filtrate was extracted with an equal volume of chloroform, and collected The chloroform extract is evaporated to dryness to obtain an extract, that is, the chloroform extract of Artemisia annua, and the obtained chloroform extract of Artemisia annua is about 0.5% of the dry weight of the raw material.

[0024] Next, the chloroform extract is dissolved in DMSO for biological activit...

Embodiment 2

[0032] The preparation method of Artemisia annua chloroform extract in the present embodiment is as follows:

[0033] Select dried Artemisia annua as raw material, grind it into powder; soak it in deionized water (pH: 10), heat it at 60°C for 3 hours, repeat twice, and collect the extract; evaporate the extract to dryness with a rotary evaporator, and collect the residual The residue was dissolved in 200 milliliters of deionized water (pH: 10), extracted 3 times with an equal volume of petroleum ether to remove grease and other petroleum ether soluble substances, and the filtrate was collected; the filtrate was extracted with an equal volume of chloroform, collected The chloroform extract is evaporated to dryness to obtain an extract, that is, the chloroform extract of Artemisia annua, and the obtained chloroform extract of Artemisia annua is about 0.5% of the dry weight of the raw material.

[0034] Next, the chloroform extract is dissolved in DMSO for biological activity tes...

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Abstract

The invention provides an artemisia apiacea extract. The artemisia apiacea extract is prepared by the following steps: selecting dry artemisia apiacea as a raw material and grinding the artemisia apiacea into powder; heating the powder by using deionized water at 50-60 DEG C for 3h, vibrating once per 15min, filtering and collecting filtrate; repeatedly extracting filter residues once; merging the filtrate; evaporating to dryness by using a rotary evaporator and collecting residues; dissolving the residues into the deionized water, extracting the solution by using isopyknic petroleum ether for 2-4h, removing grease and other petroleum ether-soluble materials and collecting percolate; and extracting by using isopyknic chloroform, collecting an extract liquid, evaporating to dryness and preparing paste, namely the artemisia apiacea chloroform extract. An experiment shows that the extract is capable of relaxing airway smooth muscle and can be used for relieving airway obstruction of an asthma patient, so that the artemisia apiacea chloroform extract can be applied to preparation of medicines for treating bronchial asthma.

Description

technical field [0001] The invention provides a chloroform extract of Artemisia annua, a preparation method of the extract and an application of the medicine for treating bronchial asthma, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Bronchial asthma (hereinafter referred to as "asthma") is a multiple chronic respiratory disease caused by allergens, and its pathogenesis is not yet fully understood. At present, there are more than 300 million asthma patients in the world, and there are nearly 30 million asthma patients in my country. The prevalence of asthma in Chinese adults in 2013 was: the prevalence of self-reported asthma was 2%, and the prevalence of symptom-based asthma was 3.9%. significantly increased 10 years ago. At present, the effective control rate of asthma is low. The main reason is that with the development of social economy and the improvement of living standards, environmental changes are accelerating, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P11/06
CPCA61K36/282A61K2236/331A61K2236/35A61K2236/39
Inventor 沈金花黄俊
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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