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A pharmaceutical composition for relaxing tracheal smooth muscle

A technology of tracheal smooth muscle and composition, applied in the field of medicine, to achieve the effect of increasing patient compliance, reducing toxic and side effects, and increasing safety

Inactive Publication Date: 2017-09-01
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, by retrieving the prior art at home and abroad, it is found that in the treatment of bronchial asthma, there is no therapeutic drug that uses Jasmine aqueous extract or Jasmine aqueous extract in combination with clarithromycin as the main active ingredient.

Method used

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  • A pharmaceutical composition for relaxing tracheal smooth muscle
  • A pharmaceutical composition for relaxing tracheal smooth muscle

Examples

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Embodiment Construction

[0015] In order to enable those skilled in the art to better understand and implement the present invention, the present invention will be further described below in conjunction with specific examples.

[0016] 1. Embodiment

[0017] The pharmaceutical compositions of Examples 1-5 of the present invention and the medicines of Comparative Examples 1 and 2 were prepared respectively according to the components and proportions in Table 1.

[0018] Table 1 embodiment and comparative example medicine component and proportioning

[0019] specific embodiment Clarithromycin (g) Jasmine Aqueous Extract (g) Example 1 0.200 0.100 Example 2 0.250 0.050 Example 3 0.267 0.033 Example 4 0.277 0.023 Example 5 0.286 0.014 Comparative example 1 0.3 0 Comparative example 2 0 0.3

[0020] The jasmine aqueous solution extracts in Examples 1-5 of the present invention and Comparative Example 2 are obtained by the following steps: ta...

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Abstract

The invention discloses a pharmaceutical composition capable of relaxing tracheal smooth muscles, and relates to the technical field of medicine. The pharmaceutical composition contains the active ingredients including a jasmine flower aqueous solution extract and clarithromycin, wherein the weight ratio of clarithromycin to the jasmine flower aqueous solution is (2-20):1. The pharmaceutical composition is applied to treatment on an asthma disease in an aerosol form, the treatment effect is obvious by jointly applying the jasmine flower aqueous solution extract and clarithromycin, few toxic and side effects are generated, the compliance of a patient is improved, and the life quality of the patient is significantly improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition for relaxing tracheal smooth muscle, which belongs to the technical field of medicine. Background technique [0002] Asthma is a common disease that threatens people's health, although it has been studied and practiced for many years. Its morbidity and mortality are still high. Asthma is an airway inflammatory disease involving several inflammatory cells such as eosinophils, T lymphocytes, macrophages, etc. and various inflammatory mediators such as chemokines, cytokines, cysteinyl leukotrienes, etc. , Inflammatory cells release inflammatory mediators to promote and amplify the inflammatory response. In addition to the inflammatory response, due to the subepithelial fibrosis of the tracheal wall, the increase in the volume and number of tracheal smooth muscle, the proliferation of blood vessels in the tracheal wall, and the increase in mucus secretion, the structural changes unique to the trachea ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/63A61P11/06A61K31/7048A61K133/00
CPCA61K31/7048A61K36/63A61K2236/331A61K2236/39A61K2300/00
Inventor 于孟飞许洋易建明马琳
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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