Esomeprazole sodium enteric-coated tablet and preparation method thereof
A technology of esomeprazole sodium and enteric-coated tablets, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as increasing gastrointestinal irritation and increasing operation complexity, and achieve increased drug use Safety, improved drug stability, improved release effect
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Example Embodiment
[0025] Example 1
[0026] Tablet core prescription
[0027]
[0028] Isolation layer formula
[0029]
[0030] Enteric layer formula
[0031]
[0032] Preparation Process
[0033] Esomeprazole sodium is uniformly mixed with lactose, sodium carboxymethyl starch and microcrystalline cellulose, sodium hydroxide aqueous solution is added, granulated, dried, magnesium stearate is added, mixed, and tableted.
[0034] The compressed tablet is coated with a barrier coat to increase the weight by 5%, and then enteric-coated to increase the weight by 15%.
Example Embodiment
[0035] Example 2
[0036] Tablet core prescription
[0037]
[0038] Isolation layer formula
[0039]
[0040] Enteric layer formula
[0041]
[0042] Preparation Process
[0043] Esomeprazole sodium, sodium carboxymethyl starch and microcrystalline cellulose are mixed uniformly, sodium carbonate aqueous solution is added, granulated, dried, magnesium stearate is added, mixed evenly, and tableted.
[0044] The compressed tablet is coated with a barrier coating to increase the weight by 6%, and then enteric-coated to increase the weight by 18%.
Example Embodiment
[0045] Example 3
[0046] Tablet core prescription
[0047]
[0048] Isolation layer formula
[0049]
[0050]
[0051] Enteric layer formula
[0052]
[0053] Preparation Process
[0054] Esomeprazole sodium, lactose and cross-linked povidone are mixed uniformly, sodium hydroxide aqueous solution is added, granulated, dried, magnesium stearate is added, mixed, and tableted.
[0055] The compressed tablet is coated with a barrier coat to increase the weight by 5%, and then enteric-coated to increase the weight by 15%.
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