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78 results about "Tracheal wall" patented technology

Degradable artificial trachea stent and production method thereof

The invention relates to a degradable artificial trachea support frame and a manufacturing method thereof, which belong to the technical field of biological medicine. The support frame is characterized by being weaved into a circular pipe shape by polyp-dioxygen cyclohexanone monofilaments or polyglycolic acid monofilaments; the longitudinal axles of a tracheal wall transversely surround a pipe-shaped annulet formed by weaving the double-layered monofilaments at intervals; the monofilaments on the inner layer of the tracheal wall are bond uniformly; collagen is uniformly covered on the surfaces of the monofilaments; and chitosan is covered on the collagen in sequence. The manufacturing method comprises the following steps: weaving the circular pipe-shaped annular support frame; dipping the support frame into 2 percent of collage solution and drying; coating chitosan solution on the surface of the inner layer; and drying for standby. After the invention is executed, the stimulation of patches to human tissues is reduced and the anti-infectious capacity is strong, so as to be beneficial to reconstruct tracheas; a double-layer structure can accommodate the support frame for rehabilitating tracheal rings and achieve double rehabilitations in aspects of physiological anatomy and function of the defective tracheas; and the coating layer of the chitosan is arranged on the inner layer, so as to be beneficial to the creeping rehabilitation of tracheal endothelium.
Owner:唐华 +3

Preparation method and application of a biological composite artificial trachea

The present invention provides a biological composite artificial trachea and its preparation method in combination with 3D printing technology. The material used in the present invention has both flexibility and certain mechanical strength, which meets the physical and mechanical properties of the trachea as a hollow organ in the thoracic cavity; secondly, The artificial trachea of ​​the present invention has a porous and loose structure, which is conducive to the diffusion of nutrients and the growth of autologous blood vessels; in addition, the present invention prints the seed cells obtained from the expansion of the recipient's own airway epithelial cells and chondrocytes in the trachea wall, The patient's rejection of the cells is avoided; moreover, the seed cells are composed of terminally differentiated mature cells, which avoids the problem of inducing differentiation and the risk of tumor formation caused by the use of stem cells; at the same time, the spatial distribution of the cells in the present invention is The printing is precise and controllable, and the distribution according to histological laws accelerates the repair process; finally, the tracheal stent can be degraded in the body, reducing the complications caused by foreign body residues in the body, and avoiding the risk of secondary surgical removal.
Owner:SHANGHAI PULMONARY HOSPITAL +1
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