12 results about "Smoke exposure" patented technology

The invention discloses a chronic obstructive pulmonary disease mouse model induced by long-term continuous cigarette smoke exposure as well as a construction method and application thereof, and the construction method comprises the following steps: introducing cigarette smoke with constant concentration into a smoke exposure device, so that a mouse is in a cigarette smoke exposure environment for a long time and maintains normal diet and drinking; performing macroscopic characterization and microcosmic index evaluation on the mouse model with the chronic obstructive pulmonary disease until clinical symptoms of the chronic obstructive pulmonary disease appear; wherein the smoke exposure device comprises a smoke mixing box, a sealed feeding exposure box and a control box, the sealed feeding exposure box provides a cigarette smoke exposure environment, and the control box maintains the stability of the cigarette smoke exposure environment. According to the method, the occurrence cause of the chronic obstructive pulmonary disease of the mouse is simulated by optimizing exposure parameter conditions, the clinical symptoms of the chronic obstructive pulmonary disease of the mouse model are evaluated in multiple dimensions, and the method accords with the symptoms and signs of the chronic obstructive pulmonary disease, is high in similarity and good in reliability, and can be used as a disease model for research of the chronic obstructive pulmonary disease.

The utility model discloses a device for constructing a COPD fruit fly model by adopting smoke exposure, which is characterized in that a sealing mechanism is arranged between a box body and a box cover, the box body is transparent, a fruit fly placing mechanism is arranged in the box body, a smoke inlet pipe is arranged on the side wall of the box body in a penetrating manner, and a smoke pushing mechanism is arranged on the smoke inlet pipe; one end of a connecting pipe of the cigarette pushing mechanism is communicated with a cigarette pushing barrel, the other end of the connecting pipe is provided with a double-layer sleeve body, the double-layer sleeve body comprises an outer sleeve body and an inner sleeve arranged in the outer sleeve body, the outer sleeve body and the inner sleeve are arranged on the periphery and the inner wall of a cigarette inlet pipe in a sleeved mode respectively, the outer sleeve body is connected with the outer wall of the connecting pipe, and the inner sleeve is communicated with the connecting pipe. The smoke pushing cylinder comprises a needle cylinder and a piston arranged in the needle cylinder in a penetrating mode. According to the smoke exposure device, smoke can enter the smoke box through the smoke inlet conveniently for smoke exposure, the smoke exposure device can be used for construction of a COPD disease model, drug treatment and drug effect evaluation, and technical support is provided for construction of the COPD model in a smoke exposure mode.

The present invention relates to compositions, methods and kits for treating or preventing the effects of smoke exposure. In particular, these compositions, methods and kits are particularly suitable for, but not limited to, treatment or prevention of acute or chronic smoke exposure. In one aspect, the invention provides a method of treating or preventing obstructive pulmonary disease associated with or caused by smoke exposure in a subject in need thereof, the method comprising administering to the subject an antisense oligonucleotide (AON) that promotes the production of endogenous soluble RAGE, thereby treating or preventing obstructive pulmonary disease associated with or caused by exposure to smoke in the subject.

The invention relates to the technical field of urban rail transit fire safety, in particular to a fire smoke analysis control strategy system applied to an urban subway tunnel, which is characterized in that a fire source is quickly positioned and initial power is estimated through sensor data, and then two core strategies of'upstream ventilation 'and'downstream ventilation' are performed in parallel. And the required critical wind speed is calculated respectively, and the critical wind speed is taken as a target ventilation parameter to drive the fire dynamic prediction model, and the time-space distribution of the temperature and the smoke concentration in the tunnel under the two strategies is simulated in a prospective manner. And finally, by quantifying the safety risk integral, calculating the risk of heat exposure and smoke exposure possibly borne by the personnel on each corresponding evacuation path, and automatically selecting and executing the optimal strategy with the lowest overall safety risk. Therefore, ventilation control and personnel evacuation safety are deeply coupled, a ventilation decision with the safety of an evacuation path as a core target is achieved on the system level, and the secondary risk that ventilation force drives smoke to evacuated crowds is effectively avoided.

The utility model belongs to the technical field of rat experiment devices, and discloses an experiment device for rat smoke exposure, which comprises a fixing assembly, the fixing assembly comprises four groups of side rods, two groups of top rods and two groups of fixing rods, and the two groups of top rods and the two groups of fixing rods are all arranged among the four groups of side rods. A sealing mechanism for sealing a rat experiment space is installed at the outer end of the fixing assembly, a collecting mechanism for collecting rat excrement is installed at the bottom of the inner wall of the sealing mechanism, a limiting mechanism for limiting the moving position of a mouse cage is installed in the collecting mechanism, and a storage mechanism for storing and containing the mouse cage is installed in the fixing assembly; the rectangular experiment space is formed by splicing the sealing mechanisms at the outer ends of the fixing assemblies, so that the sealing mechanisms are beneficial to keeping the stability of smoke concentration in the experiment process in the using process, meanwhile, the internal space of the sealing mechanisms is wide, a plurality of mouse cages can be contained at the same time, and therefore crowding and stress reactions of rats in the experiment process are reduced.

The utility model relates to an electronic cigarette atomization generation device, and relates to the technical field of electronic cigarette experiment devices, the electronic cigarette atomization generation device comprises a peristaltic pump and an atomizer, the peristaltic pump and the atomizer are arranged on a machine body; the atomizer comprises an atomization base and an atomization connector, the atomization connector is arranged above the atomization base, an air outlet and an injection head are arranged on the atomization connector in a communicating mode, and the injection head is communicated with the peristaltic pump; a heating body is arranged in the atomization base, a groove for storing tobacco tar is formed in the top of the heating body, and the injection head is communicated with the groove; a heating rod used for heating tobacco tar in the groove is arranged in the heating body. The electronic cigarette atomization generation device combined with the smoke exposure device is arranged, so that the requirement of the toxicity verification test of the electronic cigarette tobacco tar is met.

This invention relates to the field of biomedical technology, and in particular to an animal model of COPD combined with sarcopenia and the application of mesenchymal stem cells in the treatment of this disease. The method of constructing the model includes the following steps: (1) Pre-stimulation stage: On the first day of modeling, lipopolysaccharide (LPS) is administered via airway nebulization to initiate airway inflammation, and continuous exposure to cigarette smoke is implemented from the first day of modeling; during this period, LPS is administered again on the 10th to 14th day of modeling to enhance the persistence of inflammation; (2) Partial phenotype confirmation stage: Lung function tests or their alternative indicators are performed on the animals after the pre-stimulation ends; (3) While continuing to implement smoke exposure, dexamethasone proteolytic load and mechanical load regulation treatment are introduced simultaneously for the enrolled animals until the total modeling time reaches 4 to 6 weeks; (4) The endpoint airflow limitation index, weight loss and muscle strength loss index are detected, and the animals are deemed to have successfully constructed the model if they simultaneously meet the corresponding thresholds.

The invention relates to the technical field of intelligent control and biomedical experiments, in particular to a dynamic intelligent smoke exposure control method and system and a storage medium, and the method comprises the steps: obtaining the time sequence data of a smoke control state at the current moment in real time; performing feature extraction on the time sequence data of the smoke control state at the current moment to obtain a state vector; inputting the state vector into a pre-trained risk prediction model to obtain a corresponding risk value; inputting the state vector into an intelligent decision-making model to obtain a decision-making action vector; controlling an atomizing pump and a suction fan according to the decision action vector; calculating a reward value according to the risk value; and updating parameters of the intelligent decision-making model according to the reward value. According to the embodiment of the invention, the smoke and essence concentrations are regulated and controlled in real time by constructing the dynamic risk prediction model, the time-varying characteristics exposed in a real environment are simulated, and the authenticity and extrapolation value of an experimental result are effectively improved.

The invention belongs to the technical field of biological experiment equipment, and particularly provides an animal behavior experiment device for smoke exposure, which comprises an open field box body with an open top; the cover plate is detachably arranged at the top of the open field box body, and a closed experiment cavity is formed by the cover plate and the open field box body; the smoke generating device is connected with the open field box body through a pipeline and is used for conveying smoke to the experiment chamber; the behavior observation device and the optical genetic stimulation device are both integrally arranged on the cover plate, and the behavior observation device is matched with the smoke generation device and used for conducting behavioral observation when the animal is exposed to the smoke; and the photogenetic stimulation device is matched with the behavior observation device and is used for carrying out behavioral observation when the animals are subjected to photogenetic intervention. According to the device, environmental fluctuation, time delay and stress interference caused by animal transfer among different devices or step-by-step experiments in traditional research are overcome, and the research accuracy and efficiency are greatly improved.

Methods, kits, and treatment compositions for treating agricultural products to reduce or preventing wildfire smoke taint or other types of taint, including treated agricultural products, are provided. One or more treatment compositions effective in reducing or preventing wildfire smoke taint are preferably applied to agricultural products such as, for example, wine grapes prior to and / or during wildfire smoke exposure.

The present invention provides a closed smoking tool that belongs to the field of everyday items and aims to solve problems such as the difficulty of cleaning up ashes when smoking, the impact of smoke on others, and environmental pollution caused by cigarette butts. [Solution] The tool comprises a tool body, which houses a sealed combustion chamber 3, an ash collection box 6, a smoke filter 11, an ignition device 4, an electric suction port 8, a battery 7, and a smoke storage chamber 9. A smoking nozzle 10 is provided on the exterior, and the smoking nozzle is connected to the smoke storage chamber. The sealed combustion chamber is connected to the smoke filter via an air intake 2, which is in turn connected to the electric suction port and the smoke storage chamber. The ash collection box is provided at the bottom of the tool body and is connected to the sealed combustion chamber via an ash discharge port 5. The smoking nozzle remains closed when not in use. The advantages of this device are as follows: The sealed combustion chamber prevents smoke from being exposed to the outside, reducing its impact on the surrounding area. The smoke filter eliminates the need for conventional filters and reduces the generation of cigarette butts. The ash collection box allows for centralized collection and disposal of ash, making cleaning easy and highly practical.

The present invention relates to compositions, methods and kits for the treatment or prevention of effects of smoke exposure in a subject that has substantially reduced their exposure to smoke. In one aspect, the present invention provides a method of treating or preventing obstructive pulmonary disease, associated with or caused by exposure to smoke, in a subject in need thereof that has substantially reduced their exposure to smoke, the method comprising administering to the subject an antisense oligonucleotide (AON) that promotes the production of endogenous soluble RAGE, treating or preventing obstructive pulmonary disease, associated with or caused by exposure to smoke in the subject that has substantially reduced their exposure to smoke.