Application of Safflower Organic Solvent Extract in Preparation of Airway Smooth Muscle Relaxation Medicine

A technology of airway smooth muscle and organic solvent, which is applied in the application field of safflower organic solvent part extract in the preparation of airway smooth muscle relaxation medicine, which can solve the problem of lack of more effective drug control, poor curative effect of asthma drugs, and easy disease Repeated attacks and other problems to achieve the effect of relieving airway obstruction

Inactive Publication Date: 2018-01-05
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the curative effect of the existing drugs for treating asthma is not good, and the disease is prone to relapse after stopping the treatment, there is no more effective drug control, and the research on the various drug effects of safflower still needs to be developed.

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  • Application of Safflower Organic Solvent Extract in Preparation of Airway Smooth Muscle Relaxation Medicine
  • Application of Safflower Organic Solvent Extract in Preparation of Airway Smooth Muscle Relaxation Medicine
  • Application of Safflower Organic Solvent Extract in Preparation of Airway Smooth Muscle Relaxation Medicine

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific examples, so that those skilled in the art can better understand the present invention and implement it, but the given examples are not intended to limit the present invention.

[0021] 1. Preparation of Safflower Organic Solvent Extract

[0022] Safflower comes from Wuling Mountain in Hubei Province. The crushed dry safflower powder is soaked in ethanol with a volume percentage of 75%, the extract is obtained by cold soaking, the extract is evaporated to dryness under reduced pressure to obtain the extract, the extract is extracted with petroleum ether, and the extracted organic phase is evaporated to dryness under reduced pressure and concentrated into an extract, namely the safflower petroleum ether extract. The aqueous phase separated during the petroleum ether extraction is further added with ethyl acetate for extraction, and the extracted organic phase is evaporated to dryness unde...

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Abstract

The invention discloses the application of safflower organic solvent extract in preparing airway smooth muscle relaxation medicine. Studies have found that safflower can cause contraction of airway smooth muscle relaxation, and the relaxation effect is about 3 times stronger than that of the currently clinically used beta2 receptor agonist isoproterenol, which can be used for the prevention and / or treatment of asthma. In addition, the detection of isolated tracheal ring tension in experimental mice also proved that the organic solvent extract of safflower has an effective tracheal smooth muscle relaxation effect, which can be used to relieve airway obstruction in patients with asthma, and provides an efficient method for the prevention and treatment of asthma. source of new medicines.

Description

technical field [0001] The invention relates to the application of safflower organic solvent part extract in preparing airway smooth muscle relaxing medicine. Background technique [0002] Bronchial asthma (hereinafter referred to as "asthma") is a common multiple chronic respiratory disease, and its pathogenesis is not yet fully understood. At present, there are at least 300 million people in the world, and there are nearly 30 million asthma patients in my country. Asthma has become the second leading cause of death and disability in the world after cancer. According to the latest survey released at the press conference of "my country's Asthma Disease Incidence, Treatment Progress and Asthma Management Ten-Year Progress News Bulletin", from 1990 to 2000, the incidence of asthma in mainland China increased from 0.91% to 1.97%. (more than doubled). The survey data of the three cities of Beijing, Chongqing, and Guangzhou in 2010 showed that the prevalence rates of childhood a...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/286A61P11/06A61P21/02
Inventor 刘庆华赵平谈丽
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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