Anti-infection nasal vestibule covered stent and preparation method and application thereof

A covered stent and nasal vestibule technology, which is applied in the field of nasal vestibular covered stent and its preparation, can solve the problem of easy occurrence of bronchioles, bronchioles and pulmonary infections, and achieve the functions of drug loading and drug release, with strong feasibility And the promotion value, the effect of anti-infection effect is remarkable

Pending Publication Date: 2021-05-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The embodiment of the present application provides an anti-infection nasal vestibular covered stent, which solves the technical problem in the prior art that patients with artificial trachea or tracheal stent transplantation are prone to bronchi, bronchioles and lung infections, and proposes a trachea-o

Method used

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  • Anti-infection nasal vestibule covered stent and preparation method and application thereof
  • Anti-infection nasal vestibule covered stent and preparation method and application thereof
  • Anti-infection nasal vestibule covered stent and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0054] figure 1 It is a schematic structural view of the anti-infection nasal vestibular stent-graft provided in Example 1 of the present application, and the anti-infection nasal vestibular stent-graft includes:

[0055] A stent body, the shape of the stent body matches the shape of the nasal vestibule, so as to achieve a good fit between the stent body and the nasal vestibule;

[0056] lamination;

[0057] The covering film is compounded on the stent body.

[0058] Such as figure 1 As shown, the stent body 1 is braided by a single shape memory wire, and is heat-set to form a mesh structure that matches the shape of the nasal vestibule. The prepared stent body has shape memory performance, and its morphological structure can fit well with the nasal vestibule of the human body.

[0059] In this embodiment, the single shape memory wire used is a PP wire with a diameter of 0.25 mm, and the PP wire has good biocompatibility.

[0060] The bracket body has two surfaces, an upper...

Embodiment 2

[0080] An infection-resistant nasal vestibular stent graft comprising:

[0081] A stent body, the shape of the stent body matches the shape of the nasal vestibule, so as to achieve a good fit between the stent body and the nasal vestibule;

[0082] lamination;

[0083] The covering film is compounded on the stent body.

[0084] The stent body is woven with a single shape memory wire, and is heat-set to form a mesh structure that matches the shape of the nasal vestibule. The prepared stent body has shape memory performance, and its morphological structure can fit well with the nasal vestibule of the human body.

[0085] In this embodiment, the single shape memory wire used is a nickel-titanium wire with a diameter of 0.01 mm, and the nickel-titanium wire has good biocompatibility.

[0086] The bracket body has two surfaces, an upper surface and a lower surface. The lower surface is located on the underside (outer side) of the nasal vestibule, that is, the side closer to the...

Embodiment 3

[0102] combine Figure 4 , the present embodiment provides a method for preparing an anti-infection nasal vestibular stent graft, the method comprising the steps of:

[0103] Step S1: Weaving

[0104] Using a mould, adopting the method of monofilament weaving to form a bracket, the shape and size of the bracket match the nasal vestibule;

[0105] Step S2: Finalize

[0106] The shape of the stent is fixed by heat setting, and the stent body with good shape memory performance and shape and size matching the shape of the nasal vestibule is obtained;

[0107] Step S3: Lamination

[0108] The micro-nano fiber molding method is used to directly form the covering film on the upper surface and the lower surface of the stent body respectively, so as to obtain the anti-infection nasal vestibular film-covering stent.

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Abstract

The invention discloses an anti-infection nasal vestibule covered stent and a preparation method and application thereof, the nasal vestibule covered stent comprises a stent body, the shape and size of the stent body are matched with the shape of a nasal vestibule; and a covering film, wherein the covering film is compounded on the stent body. The stent body has a shape memory function and is well matched with the form structure of the nasal vestibule of a human body. The covering film is composed of at least one fiber layer, and the aperture of the fiber layer is gradually reduced from the lowermost layer of the lower covering film to the uppermost layer of the upper covering film in a gradient mode. The nasal vestibule covered stent provided by the invention can achieve gradient filtration of gas inhaled into a human body through a nose, and achieves the purpose of preventing bronchial, microbronchial and pulmonary infection of an artificial trachea or tracheal stent transplantation patient. The stent is simple in structure, convenient to manufacture, attractive in application and remarkable in anti-infection effect, medicine carrying and medicine releasing of the covered stent can be achieved, and the stent has multiple additional function attributes.

Description

technical field [0001] The invention relates to the technical field of covered stents, in particular to a nasal vestibular covered stent for anti-infection of the respiratory system of patients with tracheal stent placement or artificial tracheal transplantation, and a preparation method and application thereof. Background technique [0002] The trachea is the main organ of the human respiratory system, located between the larynx and the trachea, and mainly performs the function of gas communication. The tracheal epithelium is a pseudostratified ciliated columnar epithelium consisting of ciliated columnar cells and mucus-producing goblet cells. The epithelium is usually covered with mucus and cilia. Mucus keeps the trachea moist and contains substances that fight off bacteria and viruses. The movement of cilia can remove foreign bodies in the trachea, and by directional swinging toward the larynx, viruses, bacteria, dust, etc. inhaled into the trachea can be removed. [00...

Claims

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Application Information

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IPC IPC(8): A61F2/04
CPCA61F2/04A61F2002/046A61F2210/0014A61F2240/004A61F2250/0067
Inventor 关国平王欣悦王璐林婧王富军范禹涛
Owner DONGHUA UNIV
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