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4D-printing shape-memory-polymer-composite-material tracheal stent and preparing method thereof

A technology of memory polymers and tracheal stents, applied in stents, medical science, prostheses, etc., can solve problems such as blocked airway cilia swinging and difficult implantation of tracheal stents, so as to avoid the risk of tracheal stents, relieve pain, and relieve pain. small pain effect

Active Publication Date: 2018-12-11
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the difficulty of implanting traditional tracheal stents, secondary stenosis caused by excessively large tracheal stents and obstruction of airway ciliary swing caused by too small stent apertures, the present invention provides a 4D printed shape memory polymer composite trachea The stent and its preparation method realize the reduction of the size of the stent by shaping the method before the operation by controlling the pore size of the coating to achieve the ideal pore size, thereby reducing the pain caused to the patient during implantation. Restore the shape of the stent to achieve the medical treatment purpose of supporting the trachea, and the medicine on the film can better reach the affected area and relieve the corresponding symptoms of the patient

Method used

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  • 4D-printing shape-memory-polymer-composite-material tracheal stent and preparing method thereof
  • 4D-printing shape-memory-polymer-composite-material tracheal stent and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1.4 Preparation method of tracheal stent made of D-printed shape-memory polymer composite material.

[0043] (1) Design the three-dimensional structure of the trachea support frame with a curved rectangle as the basic structural unit. The basic structure of the trachea support frame is mesh-shaped, the central angle corresponding to each arc is 60°, and the aperture of the support frame is 3×6mm. Wall thickness 1.5mm, diameter 10mm, see attached Figure 6 shown.

[0044] (2) Using fused deposition 3D printing technology to complete the molding and printing of the shape memory polymer composite material trachea support frame, the printing line is a standard printing line of polylactic acid composite material with a mass content of nano-ferric iron tetroxide powder of 10%, and the nano-4 The particle size of the iron oxide powder is 20nm; the printing speed is 40mm / s, the layer thickness is 0.2mm, the temperature of the extrusion head is 205°C, and the temperatur...

Embodiment 2

[0047] Example 2.4 The preparation method of tracheal stent made of D-printed shape memory polymer composite material.

[0048] (1) Design the three-dimensional structure of the tracheal support frame with the curved rectangle as the basic structural unit. The basic structure of the tracheal support frame is mesh-like, the central angle corresponding to the curved edge arc is 120°, and the aperture of the tracheal support frame is 5×10mm. Wall thickness 1.5mm, diameter 10mm, see attached Figure 9 shown.

[0049] (2) Using fused deposition 3D printing technology to complete the molding and printing of the shape memory polymer composite material trachea support frame, the printing line is a standard printing line of polylactic acid composite material with a mass content of nanometer ferroferric oxide powder of 15%, and the nanometer four The particle size of the iron oxide powder is 20nm; the printing speed is 40mm / s, the layer thickness is 0.2mm, the temperature of the extrus...

Embodiment 3

[0052] Example 3.4 The preparation method of tracheal stent made of 4D printed shape memory polymer composite material.

[0053] (1) Design the three-dimensional structure of the trachea support frame with the curved side rectangle as the basic structural unit. The basic structure of the trachea support frame is mesh-like, the central angle corresponding to the curved side arc is 180°, and the aperture of the trachea support frame is 5×10mm. Wall thickness 1.5mm, diameter 20mm.

[0054] (2) Using fused deposition 3D printing technology to complete the molding and printing of the shape memory polymer composite material tracheal support frame, the printing line is a standard printing line of polylactic acid composite material with a mass content of nanometer iron tetraoxide powder of 20%, and the nanometer four The particle size of the iron oxide powder is 20nm; the printing speed is 40mm / s, the layer thickness is 0.2mm, the temperature of the extrusion head is 205°C, and the te...

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Abstract

The invention discloses a 4D-printing shape-memory-polymer-composite-material tracheal stent and a preparing method thereof, and belongs to the technical field of 4D printing. As for the problem thata traditional tracheal stent is difficult to implant, and the secondary stricture problem caused by the overlarge hole diameter of the tracheal stent, and the problem that as the hole diameter of thetracheal stent is over small, swinging of airway cilia is blocked, a compound of a shape memory polymer and nanometer iron oxide serves as a material, a curve-edge rectangle serves as a basic unit, and a tracheal-stent three dimensional structure model is designed; the tracheal-stent three dimensional structure is printed and formed with the fused deposition or direct writing printing method, is subjected to electrostatic spinning medicine carrying covering, and then is subjected to in-vitro remote excitation so that the shape of the stent is recovered, and a formed tracheal stent is obtained.The 4D-printing shape-memory-polymer-composite-material tracheal stent and the preparing method thereof are suitable for production of the tracheal stent.

Description

technical field [0001] The invention belongs to the technical field of 4D printing, and in particular relates to a tracheal stent made of a 4D printing shape-memory polymer composite material and a preparation method thereof. Background technique [0002] In the medical field, the tracheal stent is used to keep the airway unobstructed. It is an effective treatment technology to treat airway stenosis and maintain the normal function of the airway. Most of the tracheal stents currently used in clinical practice are shape memory alloy stents. Poor biocompatibility will cause many related complications. When the stent pore size is too large, the secondary stenosis of the trachea will be caused by cell tissue proliferation. When the stent pore size is small, it will affect the swing of tracheal cilia, affect the cleaning function of the airway and affect the normal progress of cell metabolism. Contents of the invention [0003] Aiming at the difficulty of implanting traditiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/844A61F2/915A61F2/94
CPCA61F2/844A61F2/915A61F2/94A61F2002/821A61F2210/0047A61F2240/001A61F2310/0097
Inventor 冷劲松张风华刘彦菊温楠白云起白青子
Owner HARBIN INST OF TECH
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