Nanogold film memory alloy esophageal stent and preparing method thereof

A technology of memory alloy and nano-gold, which is applied in the field of medical devices to achieve the effects of high thermal efficiency, material safety, and simple and fast coating process

Active Publication Date: 2015-11-11
SHANGHAI THERANOSTICS BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no preparation method of photothermal therapy stent at home and abroad.

Method used

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  • Nanogold film memory alloy esophageal stent and preparing method thereof
  • Nanogold film memory alloy esophageal stent and preparing method thereof
  • Nanogold film memory alloy esophageal stent and preparing method thereof

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preparation example Construction

[0036] A method for preparing a nano-gold film memory alloy esophageal stent with photothermal therapy function as described above, the steps are as follows:

[0037] Firstly, after cleaning the surface of the nickel-titanium alloy stent, immerse it in acetone solution and shake it for 24 hours; then take out the stent and immerse it in Tris-Buffer (pH=9), shake it for 5 hours, add 800 mg of dopamine; keep shaking, and react After 2 days; take out the stent again, immerse it in Tris-Buffer (pH=9) again, slowly add 500-900mg dopamine, and continue the reaction for 2 days; take out the alloy stent, wash it with deionized water for 3 times, and immerse it in ethylene glycol solution, then add 200-400mg of chloroplatinic acid, and shake for 5 hours; then place it in an oil bath and heat it to 100-110°C; after reacting for 3 hours, take out the bracket and wash it repeatedly with deionized water three times; then put the alloy The scaffold was immersed in deionized water, 300-600 m...

Embodiment 1

[0041] Specific steps for preparing a nano-gold film with a thickness of 5 nm: firstly, the surface of the nickel-titanium alloy stent is cleaned, immersed in an acetone solution, and shaken for 24 hours. Then take out the stent and re-immerse in Tris-Buffer (pH=9), shake and wash for 5 hours, add 800 mg of dopamine, keep shaking, after 2 days of reaction, take out the stent again, and immerse in Tris-Buffer (pH=9) again, Slowly add 900mg of dopamine, and continue to react for 2 days. The alloy stent was taken out, washed three times with deionized water, immersed in ethylene glycol solution, then added with 300 mg of chloroplatinic acid, and shaken for 5 hours. Then place it in an oil bath and heat to 100°C. After 3 hours of reaction, the scaffolds were taken out and washed three times repeatedly with deionized water. Then immerse the alloy stent in deionized water, add 300 mg of hydroxylamine, and stir for 20 minutes. Subsequently, 20 mL of 10 mg / mL chloroauric acid trihy...

Embodiment 2

[0043] Specific steps for preparing a nano-gold film with a thickness of 10 nm: firstly, the surface of the nickel-titanium alloy stent is cleaned, immersed in an acetone solution, and shaken for 24 hours. Then the scaffold was taken out and submerged again in Tris-Buffer (pH=9), shaken and washed for 5 hours, and 800 mg of dopamine was added. Keep shaking and let it react for 2 days. The stent was taken out again, submerged in Tris-Buffer (pH=9) again, 900 mg of dopamine was slowly added, and the reaction was continued for 2 days. The alloy stent was taken out, washed three times with deionized water, immersed in ethylene glycol solution, then added with 400 mg of chloroplatinic acid, and shaken for 5 hours. Then place it in an oil bath and heat to 100°C. After 3 hours of reaction, the scaffolds were taken out and washed three times repeatedly with deionized water. Then immerse the alloy stent in deionized water, add 300 mg of hydroxylamine, and stir for 20 minutes. Subse...

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Abstract

The invention belongs to the technical field of medical instruments and relates to a nanogold film memory alloy esophageal stent with a photo-thermal therapy function. A nanogold film is prepared by conducting in-situ surface chloroauric acid reduction on a high polymer material with a reduction function used for modifying the surface of a memory alloy wire under the alkaline condition. According to the preparing method, a unique nanogold surface coating method is adopted, the nanogold material is safe and free of toxicity, and the coating process is simple and quick; photo-thermal efficiency is high, and repeated use is realized. The method can be applied to nickel-titanium alloy stents in various shapes and types such as a biliary stent, an intestinal tract stent, a urinary tract stent and a tracheal stent.

Description

technical field [0001] The technical field of medical devices of the present invention mainly relates to a photothermal therapy bracket and a preparation method thereof. Background technique [0002] my country is a country with a high incidence of esophageal cancer, and its incidence rate is about 20-30 times higher than that of European and American countries, ranking fourth in cancer-related deaths. Surgery is the primary method for the treatment of esophageal cancer. However, more than 60% of the patients are already in the middle and late stages when they see a doctor, and they have basically lost the opportunity for surgical treatment. For patients with advanced esophageal cancer, dysphagia caused by malignant esophageal stricture is an important factor affecting the survival time and quality of life of patients. Due to long-term lack of water and food, coupled with the consumption of the tumor, the nutritional status is extremely poor, and complications such as hypoa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61F7/12
Inventor 陈小元宋继彬胡皓
Owner SHANGHAI THERANOSTICS BIOTECH CO LTD
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