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Medicine-carrying nanofiber membrane biliary stent and preparation method thereof

A nanofiber and drug-loaded nanotechnology, which is applied in the field of medical materials, can solve the problems of biliary stent stenosis and blockage of stent ports, and achieve the effects of increasing bile flow rate, reducing friction, and accelerating degradation rate

Inactive Publication Date: 2014-03-26
张建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the problem of biliary stent restenosis, it has been reported that polyurethane is applied on the outside of the metal stent to cover it, which can prevent the tumor from growing inward through the mesh, but it cannot solve the problem of tumor tissue growing and blocking the stent port by climbing.

Method used

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  • Medicine-carrying nanofiber membrane biliary stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Such as figure 1 As shown, a drug-loaded nanofibrous membrane biliary stent includes, from inside to outside, an inner layer of nanofibers oriented in the direction of the tube diameter 1, an inner layer of nanofibers arranged in disorder 2, a metal stent (bare without coating) scaffold) 3 and the outer layer 4 of drug-loaded degradable fibers; the inner layer 1 of nanofibers oriented in the tube diameter direction and the inner layer 2 of nanofibers arranged in disorder are adhered together; the inner layer 2 of nanofibers arranged in disorder The outer layer 4 of the drug-loaded degradable fiber is adhered together through the mesh of the metal stent 3, and the metal stent 3 is firmly fixed in the fiber membrane to prevent the detachment of the metal stent and the fiber membrane during the installation and release of the stent.

[0021] The high-voltage electrospinning machine used in this example is the TL-03 high-voltage electrospinning machine produced by Shenzhen ...

Embodiment 2

[0029] The high-voltage electrospinning machine used in this example is the TL-03 high-voltage electrospinning machine produced by Shenzhen Tongli Micro-Nano Technology Co., Ltd.; the metal bracket used is a net-shaped titanium-nickel alloy bile duct bracket sold in the market, with a diameter of 8mm and a length of 80mm .

[0030] Preparation:

[0031](1) Preparation of the inner layer of nanofibers aligned along the tube diameter direction: prepare a polyurethane solution with a concentration of 6%, and the solvent is a mixed solution of N,N-dimethylformamide and tetrachloromethane (the volume ratio of the two 2:8); fix the metal receiving rod with a diameter of 8mm on the receiver, the rotation speed of the receiver is 30r / s, the receiving distance is 10cm, the horizontal moving speed of the nozzle is 1m / s, the spinning voltage is 11kV, and the solution flow rate 0.3 mL / h, stop after 0.5h;

[0032] (2) Preparation of disorderly arranged inner layer nanofibers: stop the ho...

Embodiment 3

[0037] The high-voltage electrospinning machine used in this example is the TL-03 high-voltage electrospinning machine produced by Shenzhen Tongli Micro-Nano Technology Co., Ltd.; the metal bracket used is a net-shaped titanium-nickel alloy biliary tract bracket sold in the market, with a diameter of 8 mm and a length of 60 mm. .

[0038] Preparation:

[0039] (1) Preparation of the inner layer of nanofibers aligned along the tube diameter direction: prepare a polylactic acid solution with a concentration of 10%, and the solvent is a mixed solution of N,N-dimethylformamide and tetrachloromethane (the volume of the two Ratio 2:8); fix a metal receiving rod with a diameter of 8mm on the take-up device, adjust the speed of the receiving device to 30r / s, the receiving distance to 15cm, the horizontal moving speed of the nozzle system to 0.5m / s, and the spinning voltage to 10kV, the solution flow rate is 0.25 mL / h, stop after 1h.

[0040] (2) Preparation of disorderly arranged in...

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Abstract

The invention discloses a medicine-carrying nanofiber membrane biliary stent and a preparation method thereof. The medicine-carrying nanofiber membrane biliary stent comprises one part of nanofiber inner layers, the other part of nanofiber inner layers, a metal support and a medicine-carrying degraded fiber outer layer from inside to outside, wherein one part of nanofiber inner layers are arrayed in the pipe diameter direction, and the other part of nanofiber inner layers are arrayed disorderly. The nanofiber inner layers arrayed in the pipe diameter direction and the nanofiber inner layers arrayed disorderly are bonded together. The nanofiber inner layers arrayed disorderly and the medicine-carrying degraded fiber outer layer are boned together through meshes of the metal support, and the metal support is firmly fixed in a fiber membrane. The preparation method includes that electrostatic spinning equipment is adopted for electrostatic spinning. Compared with a micro-nano ball, the nanofiber membrane biliary stent has better structural stability, can be used for treating biliary stricture caused by tumors, has a mechanical expansion effect and a local treatment function, and can solve the biliary malignant stricture better than a common stent or a membrane-covering stent. In addition, the method can be applied to gastrointestinal tract stents and tracheal stents.

Description

technical field [0001] The invention relates to a biliary tract stent and a preparation method thereof, belonging to the technical field of medical materials. Background technique [0002] The cases of obstructive jaundice caused by tumors are increasing year by year, and the cases of recurrence of jaundice after PTCD (percutaneous transhepatic biliary drainage) still occur from time to time. The reason is mainly because the bare metal stent used can expand the biliary tract in a short period of time and form a smooth passage, but with the development of the tumor, the tumor tissue climbs along the stent to the edge and grows in the mesh, making the bile duct Restenosis occurs, and bile drainage is blocked, causing jaundice to reappear. In order to solve the problem of restenosis of biliary stents, it has been reported that polyurethane coating on the outside of the metal stent can prevent the tumor from growing inward through the mesh, but it cannot solve the problem that ...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61L31/04A61L31/06A61L31/08A61L31/16D04H1/70
Inventor 张建平叶勇谢志勇张绪平
Owner 张建平
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