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Composition containing dihydropyridine calcium channel blocker and preparation method thereof

A technology of calcium channel blocker and dihydropyridine, which is applied in the field of pharmacy and can solve the problems of enhanced side effects, large dosage of drugs, and insignificant drug synergy.

Inactive Publication Date: 2009-10-07
YANGZHOU PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Clinically, several antihypertensive drugs are often used in combination, but its disadvantages are: the dosage of drugs is large, and the synergistic effect of some drugs is not obvious
The combination of certain drugs also enhances its side effects, and dihydropyridine calcium channel blockers have been found to have the disadvantage of large blood pressure fluctuations in the treatment of hypertensive disorders
[0016] In the patent and scientific literature, no combination of the dihydropyridine calcium antagonist felodipine and the angiotensin-converting enzyme inhibitor enalapril is found for the prevention and treatment of hypertension

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prescription 1

[0033] The lubricant is, micronized silica gel, magnesium stearate

[0034] Felodipine 5g

[0035] HPMC (K4M) 25g

[0036] HPMC (E50) 10g

[0037] Mannitol 8g

[0038] Appropriate amount of talcum powder

[0039] Appropriate amount of carbomer

[0040]

[0041] Makes 1000 pieces

[0042] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 5g of felodipine, add 8g of mannitol, 40g of HPMC (K4M), 40g of HPMC (E50) to make soft materials, granulate with a 20-mesh sieve, dry at 60°C, mix the dried granules with talcum powder evenly, and press 1000 tablets .

[0043] In addition, 5 g of enalapril and an appropriate amount of acrylic resin were dissolved in an appropriate solvent to prepare a coating liquid, and the tablet core was coated to obtain a sustained-release tablet.

Embodiment 2

[0045] Prescription 2

[0046] Felodipine 5g

[0047] HPMC (K4M) 50g

[0048] HPMC (E50) 10g

[0049] Microcrystalline Cellulose 10g

[0050] Appropriate amount of carbomer

[0051] Micropowder silica gel amount

[0052]

[0053] Makes 1000 pieces

[0054] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 5g of felodipine, add 10g of microcrystalline cellulose, 40g of HPMC (K4M), 40g of HPMC (E50) to make soft materials, granulate with a 20-mesh sieve, dry at 60°C, mix the dried granules with micropowder silica gel evenly, and press 1000 pieces.

[0055] In addition, 5 g of enalapril and an appropriate amount of acrylic resin were dissolved in an appropriate solvent to prepare a coating liquid, and the tablet core was coated to obtain a sustained-release tablet.

Embodiment 3

[0057] Prescription 3

[0058] Felodipine 5g

[0059] HPMC (K4M) 25g

[0060] HPMC (E50) 40g

[0061] Microcrystalline Cellulose 10g

[0062] Mannitol 10g

[0063] Appropriate amount of carbomer

[0064]

[0065] Makes 1000 pieces

[0066] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Get 5g felodipine, add microcrystalline cellulose 10g, mannitol 10g, HPMC (K4M) 40g, HPMC (E50) 40g soft material, 20 mesh sieves granulate, 60 ℃ dry, the granule after drying is mixed with stearin Magnesium acid mixed evenly, compressed 1000 tablets.

[0067] In addition, 5 g of enalapril and an appropriate amount of acrylic resin were dissolved in an appropriate solvent to prepare a coating liquid, and the tablet core was coated to obtain a sustained-release tablet.

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Abstract

The invention discloses a composition containing a dihydropyridine calcium channel blocker and a preparation method thereof and relates to a sustained-release preparation of felodipine, which comprises felodipine which is dihydropyridine calcium channel blocker and function as an active ingredient, enalapril which is angiotensin converting enzyme inhibitor, as well as a slow release material, a filling agent and a lubricating agent which function as auxiliary materials; wherein the slow release material contains hydroxypropyl methylcellulose. As the enalapril which is angiotensin converting enzyme inhibitor is added in coating solution, the curative effect of the sustained-release preparation is improved.

Description

technical field [0001] The invention relates to a composition containing a dihydropyridine calcium antagonist and an angiotensin-converting enzyme inhibitor drug, and a preparation method of the composition, belonging to the field of pharmacy. Background technique [0002] Hypertension (Hypertension) is a worldwide common disease, the prevalence of which is as high as 10% to 20% in all countries in the world, and can lead to cerebrovascular, heart, and kidney lesions. It is a major disease that endangers human health. Illness, that is, the need to take medicine for life, has a great dependence on therapeutic drugs. With the development of my country's economy and the improvement of people's living standards, hypertension has increasingly become an important public health problem. [0003] Reasonable use of antihypertensive drugs according to the condition can maintain the blood pressure at a normal or close to normal level, which can relieve symptoms, delay the progression ...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/40A61K9/20A61P9/12
Inventor 胡一桥秦雄剑
Owner YANGZHOU PHARM CO LTD
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