37 results about "Urethral stents" patented technology

The invention relates to the field of the preparation of urethral stents, and discloses a polycaprolactone-collagen-fibroin nano three-dimensional porous stent and a preparation method thereof. The preparation method comprises the following steps of dissolving waste mulberry silk in a 0.1 percent of Na2CO3 aqueous solution, and repeatedly boiling for half an hour, so as to extract silk fibroin; dissolving the silk fibroin at a high temperature by using a ternary solution, dialyzing and filtering, and then putting at a room temperature for drying to form a regenerated silk fibroin membrane; dissolving the regenerated silk fibroin membrane, water-soluble collagen and polycaprolactone in hexafluoroisopropanol together, so as to form a mixed solution; carrying out electrostatic spinning on the mixed solution through a rotary receiving device, so as to obtain the nano three-dimensional porous stent, wherein a rotation speed is 300 to 500 revolutions per minute, and the diameter of a rotating shaft is 2 to 6 millimeters. The stent provided by the invention is convenient and efficient to process and manufacture, is convenient to apply, moreover, is convenient for adjusting various performances of a material, is stale in structure, and has certain mechanical strength to support the growth of a fresh tissue.

The invention relates to the field of preparation of urethral stents and discloses a method for culturing oral mucosa cells. The method comprises the following steps: separating oral mucosal epithelium and connective tissues of a rat by using digestive enzymes, and digesting by using pancreatin so as to remove the connective tissues, thereby obtaining the oral mucosa cells; inoculating the oral mucosa cells to mouse fibroblast cells 3T3 which are inactivated by mitomycin, and mixing keratinocyte serum-free culture solution KSFM and DMEM to form the mixed solution; and culturing the oral mucosa cells inoculated to the cells 3T3 by adopting the mixed solution. According to the method disclosed by the invention, the separation purity of the oral mucosa cells is improved, and the adherence and proliferation capacities of seed cells can be improved.

The invention aims to provide a spiral urethral stent and a production method thereof. The spiral urethral stent is made of polymer composites. The polymer composites are formed by compositing nondegradable high polymer materials and biodegradable high polymer materials. The nondegradable high polymer materials and the biodegradable high polymer materials are mixed uniformly according to a certain proportion, and are extruded to be high polymer material filaments through an extruding machine at a certain melting temperature. The production method of the spiral urethral stent comprises the following steps: winding the high polymer material filaments on a mold to be a spiral shape; and shaping for 0.5h to 48h at the temperature of 40 DEG C to 90 DEG C so as to form the spiral urethral stent. The stent can be partially degraded within a controlled range, and after urethral repair is finished, the partial degraded stent can be taken out from the urethral.

The invention provides a urethral stent and a preparation method and an application thereof. The urethral stent comprises a stent base body and a medicine film arranged on the outer surface of the stent base body, and the medicine film comprises controlled release factors and medicine; when the urethral stent is implanted into the urethra, the stent base body plays a role in supporting and draining the urethra, the medicine film is used for preventing or reducing restenosis of the urethra, and the urethral stent has the treatment effect of being low in dosage and high in efficiency, and has the long medicine release period and the good slow release capacity. Besides, the urethral stent can play a targeting role, the situation that the liver needs to be metabolized firstly during oral administration is effectively avoided, the dosage is about 10% of that of an oral administration or injection mode, and the side effect of the medicine on the whole body is greatly reduced.

The invention discloses a biodegradable tissue engineering urethral stent and a preparation method thereof. The biodegradable tissue engineering urethral stent is made of a copolymer formed by polylactic acid-co-glycolate, polycaprolactone and a solubilizer according to the weight ratio of 70 to 30 to (2-10). The preparation method of the biodegradable tissue engineering urethral stent comprises the following steps of a) blending preparation of a modified material solution, b) medical image processing and modeling, c) 3D template printing and d) stent preparation. PLGA and PCL biodegradable polymers are subjected to solution co-mixing modification, and triethyl citrate is added as the solubilizer, and the blending ratio and the content of the solubilizer are adjusted, so that the toughnessof the modified material is relatively and greatly improved while the flexibility and the tensile strength are kept; and based on a 3D printing technology and in combination with medical image data and software processing, a soluble template can be printed for the focus of a patient, and the personalized tissue engineering urethral stent is prepared.

Biodegradable implants including an ECM material and methods for treating a pelvic floor condition are described. ECM particles can be present within or on the surface of a pelvic implant, such as a biodegradable mesh, a pouch, or a urethral stent. After implantation the implant can provide tissue support, degrade over a period of time, and deposit the ECM material in the implantation area for regeneration of tissue and long term benefit.

The invention discloses an absorbable tubular stent. The absorbable tubular stent is characterized in that the tubular stent is made by blending of polylactic acid and acylated chitosan, and the wall of the tubular stent is provided with or without a porous structure or pattern structure. Due to addition of the acylated chitosan, local acidity generated by the polylactic acid in degradation can be regulated, and oligosaccharides and monosaccharide obtained by degradation of the acylated chitosan can be absorbed and used by organisms, so that high biocompatibility, degradability and absorbability are achieved; the tubular stent has excellent mechanical strength and press resilience. The absorbable tubular stent can be planted in vivo by surgeries to serve as an intravascular stent and is applicable to treatment of embolism or blood vessel lumina narrowing caused by vascular diseases; the absorbable tubular stent can also serve as a biliary stent to be applied to treatment of cholestasis and pancreaticobiliary obstruction caused by pancreatobiliary neoplasms; the absorbable tubular stent can further serve as a urethral stent to be applied to treatment of dysuria resulted from urethral compression caused by prostatic hyperplasia. The absorbable tubular stent can be degraded and absorbed in vivo finally along with lesion repair, in-vivo long-term retention is avoided, and the absorbable tubular stent has a promising market prospect.

An apparatus including a first layer, where the first layer includes a scaffold structure forming an inner lumen along a length of the scaffold structure, and where the first layer includes a bioresorbable material; and a second layer on the first layer, where the second layer includes a bioresorbable material, wherein the second layer surrounds a majority of the first layer, and where the secondlayer is configured to hydroscopicly swell.

The invention provides a stent suitable for a urethral bent part. A body of the urethral stent is of a tubular structure made of a degradable or non-degradable material; the tubular structure is in astraight tube state before being implanted; at least one part of the tubular structure is bent after being implanted into a human body; the tube wall of the tubular structure is formed by arranging and combining concave hexagonal structures; and, in the concave hexagon at the bent position after being implanted into the human body, the included angle theta formed by the straight edges and the inclined edges of the concave hexagons sequentially arranged from the bent outer side to the bent inner side is gradually increased. After the urethral stent in the invention is implanted into a urethralstenosis part, both the inner diameter and the length of the stent can be increased by means of balloon dilatation and the like; furthermore, the stent can be bent at the same time after being implanted so as to adapt to physiological bending of a urethral membrane part, a ball part and a pubis anterior bending part; and thus, the problems of intimal hyperplasia, stent restenosis and the like caused by urethral straightening due to overlarge rigidity of the stent are solved.

The invention discloses a preparation method of a 3D printing hydrogel urethral stent. The preparation method comprises the following steps: S1, preparing an SA/Gel/rGO composite hydrogel solution; s2, preparing an SA/Gel/rGO hydrogel scaffold by using 3D printing; s3, putting the printed SA/Gel/rGO hydrogel stent into a low-temperature environment of-85 DEG C to-80 DEG C, and freezing for 2-2.5 hours; s4, putting the frozen SA/Gel/rGO hydrogel stent into a vacuum freeze-drying machine for freeze-drying, wherein the freeze-drying time is 12 to 13 hours; s5, the freeze-dried SA/Gel/rGO hydrogel scaffold and 5% CaCl2 are subjected to crosslinking, the crosslinking time is 30-35 minutes, and after crosslinking, the scaffold is washed with sterilized water; and S6, carrying out secondary freeze-drying on the cleaned SA/Gel/rGO hydrogel scaffold, and then storing in a vacuum container for later use. The SA/Gel/rGO nano-composite hydrogel is prepared by introducing an rGO solution into an SA/Gel mixed solution and is printed, so that the swelling property, the pore size and the tensile property of the hydrogel can be well improved.

The invention provides a preparation method of a urethral stent and the urethral stent. The preparation method comprises the following steps: preparing a PLLA membrane with good toughness and good mechanical strength from lecithin and PLLA, putting a first PLLA stent into an alkaline solution to modify the first PLLA stent so as to activate carboxyl on a surface of the first PLLA stent to obtain a second PLLA stent, firstly reacting the second PLLA stent with EDC to generate an intermediate product, then reacting with NHS to form a group easy to bind to amino to obtain a third PLLA stent, covalently grafingchitosan on a surface of the third PLLA stent to obtain a fourth PLLA stent, and then binding individual molecules of chitosan into a network structure through a surface cross-linking agent to obtain the urethral stent. Due to a fact that chitosan molecules are only distributed on a surface of the third PLLA stent, the prepared urethral stent is not compact and crisp, has good mechanical properties, and can prevent disintegration and fragmentation from blocking the urethra.

The invention discloses a high-strength urethral stent easy to recycle, and the stent comprises a stent body; the stent body comprises a guiding section, a transition section and an anchoring section which are sequentially arranged from the near end to the far end; the outer diameter of the anchoring section is greater than that of the guiding section, one end of the transition section is connected with the guiding section, and the other end of the transition section is connected with the anchoring section; the outer diameter of the transition section is gradually increased from one end to the other end, the outer diameter of the anchoring section is gradually decreased from the near end to the far end, and the stent body is of an integrally-formed structure. When the stent changes from the guide section to the anchoring section through the transition section, the outer diameter of the stent is gradually increased, so that the anchoring section can be limited at a bladder neck opening after entering the bladder neck due to the size difference; due to the fact that the far end of the anchoring section of the support is in an inward-contracting shape, the sheath tube is arranged at the far end of the anchoring section of the support, the support can be smoothly contracted into the sheath tube, and guiding and recycling of the support are achieved.

The invention relates to the technical field of medical instruments, and provides a self-anchored prostate hanging-type urethral stent, a visible release catheter and a use method. The self-anchored stent comprises a supporting line; barbs are arranged on the supporting line; the tail of the supporting line is provided with a gasket; the gasket is used for distracting prostate tissue to expand the urethra; the supporting line is a non-absorbable suture line; a first barb is made of metal and used for being interlocked with a puncture needle; and the barbs play a role of a self-anchored fixing stent. By means of the technical scheme, the defects of the prior art in treatment of prostatic hyperplasia: the cost of generally adopted surgical treatment is high, bleeding and tissue losses can be caused, and the male sexual function is affected, are solved. While existing urethral stent interventional therapy has the problems that the treatment effect is poor, recurrent calculous obstruction is easy to occur, the stent is easy to displace and fail, and difficult to take out after failure and the like.

The invention provides a structure and function bionic urethral stent and a preparation method thereof. The preparation method comprises the following steps of: (1) uniformly mixing an oxidized bacterial cellulose nanofiber dispersion liquid and a decellularized matrix solution, pouring the mixture into a mold I until the mold I is completely filled, and performing freeze drying to obtain an uncrosslinked porous stent; (2) putting the uncrosslinked porous stent into a cross-linking agent solution, performing cross-linking, rinsing the cross-linked porous stent with water, and performing freeze drying to obtain a cross-linked porous stent; and (3) pouring a mixed solution II consisting of oxidized bacterial cellulose nanofibers, a modified or unmodified natural polymer material, a gelling aid and water into a silica gel mold II until the silica gel mold II is completely filled, fixing the cross-linked porous stent on the mold II, enabling the cross-linked porous stent to be in contact with the mixed solution II, and standing for a period of time to obtain the structure and function bionic urethral stent. The prepared stent consists of a hydrogel layer of a bionic urethral mucosa and a porous layer of a bionic urethral cavernous body, can be rapidly epithelized and vascularized after being implanted into a body, and has a good urethral defect repair effect.

The invention discloses a preparation method of degradable metal molybdenum and alloy for ureteral and urethral stents. The alloy comprises the following components in percentage by mass: 0.2-17 wt% of Zn, 0-6 wt% of Fe, 0.2-17 wt% of Mg and 0-15 wt% of Cu, and the rest metal is Mo. The elements such as Mo, Zn, Fe, Mg, Cu and the like are uniformly mixed, and vacuum arc melting is performed to obtain the alloy. The molybdenum-based alloy has good mechanical properties and is easy to process, and the properties such as strength, toughness and plasticity meet the requirements of human body implant materials for biliary tracts and the like. The surface of the stent is coated with anti-stenosis, anti-urethral infection, antibacterial and other polymer drugs. The five elements of Mo, Zn, Fe, Mg and Cu are the elements necessary for a human body, magnesium is an activating agent and an auxiliary factor of various enzymes, zinc ions participate in in-vivo balance and immune reaction, iron is a main substance for maintaining life and is an important component of hemoglobin of the human body, a degradation product of copper has a certain antibacterial effect, and molybdenum can prevent anemia and promote development. The molybdenum-based alloy ureteral and urethral stent has good biological performance, and the degradation process and the product are safe and effective to a matrix.

A penis build template (100) may include an adhesive film (102) configured for adhesion to donor skin. The penis build template includes a first section (106) defined on the adhesive film to identify an outer penis flap of the extracted donor skin when the adhesive film adheres to the donor skin, and a second section (108) defined on the adhesive film to identify an epithelium-removed flap of the extracted donor skin when the adhesive film adheres to the donor skin. An implantable device for urethral construction includes a tubular stent (500) configured to be coupled to a natural urethra of a patient, the tubular stent being inoculated with urethral cells of the patient from which a urethral segment grows on the tubular stent while the tubular stent is disposed within the patient.

The invention discloses a multilayer drug-loaded PLGA wire material, a preparation method and application, and belongs to the field of medical materials. The method comprises the following steps of firstly, preparing a PLGA solution; then uniformly dispersing a drug into the PLGA solution to obtain a drug-PLGA solution; soaking the formed PLGA wires into the drug-PLGA solution, taking out the soaked PLGA wires, and curing the PLGA wires to form a surface coating after a solvent is volatilized, so as to obtain PLGA wires with single-layer drug coatings; and transferring the PLGA wires into thedrug-PLGA solution again, and repeating the steps to obtain the multilayer drug-loaded PLGA wire material. The wire material is good in physical and chemical properties and biocompatibility, and due to the characteristic of multi-layer drug loading, the material has higher drug loading capacity and longer drug release period. With the multilayer drug-loaded PLGA wire as a base material, a stent material with a net structure, a tubular structure and other controllable structures can be constructed, and the stent material can be used for research of clinically constructing tissue support and repair materials such as a paranasal sinus stent, an airway stent and a urethral stent and the like.