Biodegradable tissue engineering urethral stent and preparation method thereof

Abstract

The invention discloses a biodegradable tissue engineering urethral stent and a preparation method thereof. The biodegradable tissue engineering urethral stent is made of a copolymer formed by polylactic acid-co-glycolate, polycaprolactone and a solubilizer according to the weight ratio of 70 to 30 to (2-10). The preparation method of the biodegradable tissue engineering urethral stent comprises the following steps of a) blending preparation of a modified material solution, b) medical image processing and modeling, c) 3D template printing and d) stent preparation. PLGA and PCL biodegradable polymers are subjected to solution co-mixing modification, and triethyl citrate is added as the solubilizer, and the blending ratio and the content of the solubilizer are adjusted, so that the toughnessof the modified material is relatively and greatly improved while the flexibility and the tensile strength are kept; and based on a 3D printing technology and in combination with medical image data and software processing, a soluble template can be printed for the focus of a patient, and the personalized tissue engineering urethral stent is prepared.

Description

【Technical field】 [0001] The invention relates to the technical field of urethral stents, in particular to the technical field of a biodegradable tissue engineering urethral stent and a preparation method thereof. 【Background technique】 [0002] At present, patients with long distance lesions in the urethral stricture usually need to replace the stricture urethra for treatment. Oral mucosa such as buccal mucosa, lip mucosa, and tongue mucosa are currently the best transplant materials in the world, but their short-term non-renewability and limitations, as well as complications at the donor site of the patch material after harvesting (such as parotid duct injury and mastication) Myopathy, etc.) still cannot be perfectly resolved. [0003] In the 1990s, Langer et al. proposed the concept of tissue engineering. The most basic concept of tissue engineering is to separate and cultivate cells in vitro, that is, to plant seed cells on a scaffold with a specific spatial structure,...

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Problems solved by technology

For example, Xu et al. (C. Xu, R. Inai, M. Kotaki and S. Ramakrishna, Tissue Eng., 2004, 10, 1160-1168.) also used electrospinning technology to weave PLCL-75 into fine particles with a diameter of only 550nm. Silk, forming a scaffold with high porosity and low density, has great application prospects in bladder tissue engineering, but its mechanical properties still need to be improved

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