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Biodegradable tissue engineering urethral stent and preparation method thereof

A technology of tissue engineering and urethra, which is applied in the field of urethral stent, can solve the problems of high porosity and low density, achieve the effect of improving toughness, controllable shape and size, and improving the success rate of surgery

Inactive Publication Date: 2020-07-28
ZHEJIANG SINOU ENVIRONMENTAL PROTECTION EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Xu et al. (C. Xu, R. Inai, M. Kotaki and S. Ramakrishna, Tissue Eng., 2004, 10, 1160-1168.) also used electrospinning technology to weave PLCL-75 into fine particles with a diameter of only 550nm. Silk, forming a scaffold with high porosity and low density, has great application prospects in bladder tissue engineering, but its mechanical properties still need to be improved

Method used

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  • Biodegradable tissue engineering urethral stent and preparation method thereof
  • Biodegradable tissue engineering urethral stent and preparation method thereof
  • Biodegradable tissue engineering urethral stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1, Preparation of PLGA / PCL / TEC (70:30:2) scaffold:

[0041] a) Preparation of modified material solution blending: weigh 10.5g of polylactic acid-co-glycolic acid ester, 4.5g of polycaprolactone, 0.12g of p-toluenesulfonic acid and 0.3g of triethyl citrate (relatively The polymer mass is 2%), heated and stirred at 60°C and dissolved in 80ml of 1,2-dichloroethane. Then the temperature was raised to 110°C and then heated to reflux for 4h. After cooling to room temperature, under vigorous stirring, 180ml of absolute ethanol was slowly added dropwise to produce a large amount of white flocculent precipitate. Then the precipitate was filtered out with suction and rinsed several times with ethanol, and then dried with an infrared lamp to obtain a blend material of PLGA and PCL, which was recorded as PLGA / PCL / TEC 70:30:2. Among them, polylactic acid-co-glycolic acid ester is PLGA-75, a copolymer formed of lactic acid and glycolic acid in a weight ratio of 3:1.

[00...

Embodiment 2

[0045] Example 2, Preparation of PLGA / PCL / TEC (70:30:4) scaffold:

[0046] The content of triethyl citrate is 0.6g (4% relative to the polymer mass), and the others are the same as in Example 1.

Embodiment 3

[0047] Example 3, Preparation of PLGA / PCL / TEC (70:30:6) scaffold:

[0048] The content of triethyl citrate is 0.9g (6% relative to the polymer mass), and the others are the same as in Example 1.

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Abstract

The invention discloses a biodegradable tissue engineering urethral stent and a preparation method thereof. The biodegradable tissue engineering urethral stent is made of a copolymer formed by polylactic acid-co-glycolate, polycaprolactone and a solubilizer according to the weight ratio of 70 to 30 to (2-10). The preparation method of the biodegradable tissue engineering urethral stent comprises the following steps of a) blending preparation of a modified material solution, b) medical image processing and modeling, c) 3D template printing and d) stent preparation. PLGA and PCL biodegradable polymers are subjected to solution co-mixing modification, and triethyl citrate is added as the solubilizer, and the blending ratio and the content of the solubilizer are adjusted, so that the toughnessof the modified material is relatively and greatly improved while the flexibility and the tensile strength are kept; and based on a 3D printing technology and in combination with medical image data and software processing, a soluble template can be printed for the focus of a patient, and the personalized tissue engineering urethral stent is prepared.

Description

【Technical field】 [0001] The invention relates to the technical field of urethral stents, in particular to the technical field of a biodegradable tissue engineering urethral stent and a preparation method thereof. 【Background technique】 [0002] At present, patients with long distance lesions in the urethral stricture usually need to replace the stricture urethra for treatment. Oral mucosa such as buccal mucosa, lip mucosa, and tongue mucosa are currently the best transplant materials in the world, but their short-term non-renewability and limitations, as well as complications at the donor site of the patch material after harvesting (such as parotid duct injury and mastication) Myopathy, etc.) still cannot be perfectly resolved. [0003] In the 1990s, Langer et al. proposed the concept of tissue engineering. The most basic concept of tissue engineering is to separate and cultivate cells in vitro, that is, to plant seed cells on a scaffold with a specific spatial structure,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/00A61L27/50A61L27/56A61L27/58B33Y70/10B33Y80/00A61F2/82
CPCA61F2/82A61F2240/002A61L27/00A61L27/18A61L27/50A61L27/56A61L27/58B33Y70/00B33Y80/00C08L67/04
Inventor 万戈
Owner ZHEJIANG SINOU ENVIRONMENTAL PROTECTION EQUIP CO LTD
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