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A biodegradable polymer porous urethral repair scaffold and its preparation method

A polymer and polymer material technology, applied in the field of medical repair and tissue engineering, can solve the problems of limited material sources, no clinical application data, and the impracticality of repairing long-term tubular defects of the urethra, and achieve simple and efficient preparation process Convenience and the effect of avoiding the residue of organic solvents and porogens

Inactive Publication Date: 2015-09-09
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, artificially synthesized biodegradable materials have been tried, such as polycaprolactone (PCL), lactic acid-caprolactone copolymer (PLA-CL), lactic acid-glycolic acid copolymer (PLGA), polylactic acid (PLA), etc. , cell experiments and animal experiments have achieved certain results, but there is no clinical application data
[0007] At the same time, there are also reports on the use of decellularized matrix to reconstruct the urethra. Animal experiments and clinical applications have shown certain advantages. However, the sources of such materials are very limited, and it is obviously unrealistic to repair long-term tubular defects of the urethra.

Method used

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  • A biodegradable polymer porous urethral repair scaffold and its preparation method
  • A biodegradable polymer porous urethral repair scaffold and its preparation method
  • A biodegradable polymer porous urethral repair scaffold and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Polycaprolactone urethral repair scaffolds with inner diameters of 2.5mm, 3.5mm and 4.5mm were prepared.

[0030] Weigh 4g of PCL and dissolve in 20ml of dichloromethane, heat and condense to reflux for 1 hour to dissolve and form an oil phase. Weigh 15g of ammonium bicarbonate and dissolve in 100ml of water, and dissolve at room temperature until completely dissolved to form an aqueous phase. The water phase and the oil phase are mixed at a volume ratio of 1:3 and homogenized at a speed of 2500 rpm to form a viscous emulsion. Quickly insert glass rods with diameters of 2.5mm, 3.5mm, and 4.5mm into the emulsion, and immediately take them out after stirring and dry them at room temperature for 12 hours, then freeze-dry the samples to remove organic solvents, and obtain porous polymer Urethral repair stent.

[0031] The obtained polymer porous urethral repair scaffold has good toughness, and moderate stretching, curling or folding in half will not cause fracture, but th...

Embodiment 2

[0036] PLA-CL (7:3) urethral repair scaffolds with inner diameters of 2.5mm, 3.5mm, and 4.5mm were prepared.

[0037] Weigh 4g of PLA-CL (7:3) and dissolve in 20ml of dichloromethane / chloroform (dichloromethane occupies 80% of the volume), heat and reflux for 1 hour to dissolve and form an oil phase. Weigh 15g of ammonium bicarbonate and dissolve in 100ml of water, and dissolve at room temperature until completely dissolved to form an aqueous phase. The water phase and the oil phase are mixed at a volume ratio of 1:2 and homogenized at a speed of 2500 rpm to form a viscous emulsion. Quickly insert glass rods with diameters of 2.5mm, 3.5mm, and 4.5mm into the emulsion, and immediately take them out after stirring and dry them at room temperature for 12 hours, then freeze-dry the samples to remove organic solvents, and obtain porous polymer Urethral repair stent.

[0038] The obtained polymeric porous urethral repair scaffold has good toughness, moderate stretching, curling or...

Embodiment 3

[0043] PLA-CL (8:2) urethral repair scaffolds with inner diameters of 2.5mm, 3.5mm and 4.5mm were prepared.

[0044]Weigh 4g of PLA-CL (8:2) and dissolve in 20ml of dichloromethane / ethyl acetate (dichloromethane occupies 70% of the volume), heat and reflux for 1 hour to dissolve and form an oil phase. Weigh 15g of ammonium bicarbonate and dissolve in 100ml of water, and dissolve at room temperature until completely dissolved to form an aqueous phase. The water phase and the oil phase are mixed at a volume ratio of 1:4 and homogenized at a speed of 2500 rpm to form a viscous emulsion. Quickly insert glass rods with diameters of 2.5mm, 3.5mm, and 4.5mm into the emulsion, and immediately take them out after stirring and dry them at room temperature for 12 hours, then freeze-dry the samples to remove organic solvents, and obtain porous polymer Urethral repair stent.

[0045] The obtained polymeric porous urethral repair scaffold has good toughness, moderate stretching, curling o...

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Abstract

The invention discloses a biodegradable macromolecule urethra repairing support. The biodegradable macromolecule urethra repairing support is characterized by being a tissue engineering support with a tubular appearance shape and being prepared from macromolecular materials which can be completely biodegraded, the support is soft and has toughness, the microstructure of the support is a porous three-dimensional space, the average pore size is 20-200 microns, the support has good biocompatibility, and cells can be planted. The invention also discloses a preparation method of the biodegradable macromolecule urethra repairing support. The prepared urethra repairing support shows certain rigidity and necessary toughness, can endure strong tensile force, and is conducive to restoration of the shape of the support when being extruded and has good biocompatibility, and urethra mucous epithelium cells can be adhered and propagated on the support. According to the prepared urethra repairing support, residual of organic solvents and pore-foaming agents sare avoided, biological assessment is safer, a preparation process is simpler and more convenient, cost is lower, and the prepared urethra repairing support is more applicable to clinical application.

Description

technical field [0001] The invention relates to a urethral repair bracket and a preparation method thereof, in particular to a biodegradable polymer porous urethra repair bracket and a preparation method thereof, belonging to the field of medical repair and tissue engineering. Background technique [0002] Many congenital (such as rugged shape) and acquired factors (such as trauma, war wounds, infection, tumors, etc.) can cause urethral defects, strictures and dysfunction. Due to the lack of ideal repair materials, its repair and reconstruction has always been a challenging problem in urology. [0003] For the treatment of the above-mentioned urethral defects and posterior urethral stricture-related diseases, free skin (mucosa) transplantation or local pedicled flap transfer is often used for repair in clinic, but free skin (mucosa) transplantation often leads to urethral stricture due to contracture, frequent urination. The incidence rate is also high; local pedicled flap ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61F2/04A61F2/82
Inventor 魏岱旭闫志强钟建何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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