Preparation method of 3D printing hydrogel urethral stent

A 3D printing and hydrogel technology, applied in the field of 3D printing hydrogel urethral stents, can solve the problems of fast degradation rate, easy to be destroyed, unstable hydrogen bond cross-linking, etc., to achieve enhanced dispersion, good elasticity, enhanced The effect of tensile properties
CN114681675APending Publication Date: 2022-07-01张楷乐
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
张楷乐
Publication Date
2022-07-01

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Abstract

The invention discloses a preparation method of a 3D printing hydrogel urethral stent. The preparation method comprises the following steps: S1, preparing an SA / Gel / rGO composite hydrogel solution; s2, preparing an SA / Gel / rGO hydrogel scaffold by using 3D printing; s3, putting the printed SA / Gel / rGO hydrogel stent into a low-temperature environment of-85 DEG C to-80 DEG C, and freezing for 2-2.5 hours; s4, putting the frozen SA / Gel / rGO hydrogel stent into a vacuum freeze-drying machine for freeze-drying, wherein the freeze-drying time is 12 to 13 hours; s5, the freeze-dried SA / Gel / rGO hydrogel scaffold and 5% CaCl2 are subjected to crosslinking, the crosslinking time is 30-35 minutes, and after crosslinking, the scaffold is washed with sterilized water; and S6, carrying out secondary freeze-drying on the cleaned SA / Gel / rGO hydrogel scaffold, and then storing in a vacuum container for later use. The SA / Gel / rGO nano-composite hydrogel is prepared by introducing an rGO solution into an SA / Gel mixed solution and is printed, so that the swelling property, the pore size and the tensile property of the hydrogel can be well improved.
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Description

technical field

[0001] The invention belongs to the technical field of 3D printing hydrogel urethral stents, and in particular relates to a preparation method of a 3D printing hydrogel urethral stent. Background technique

[0002] Although biomimetic tissues and organs can be cultured in vitro, using traditional methods such as electrospinning, rapid prototyping, and freeze-drying, the fabricated biomimetic tissues cannot form three-dimensional structures compared to scaffolds. In addition, cells did not attach uniformly to the scaffold. Direct seeding of cells on the scaffolds may lead to cell death, further causing tissue or organ necrosis. 3D printing is an emerging technology that already has a wide range of applications in the field of tissue engineering. Compared with traditional manufacturing techniques, great progress has been made, but there are still problems such as low cell seeding efficiency, uneven distribution, and low spatial resolution.

[0003] Due to th...

Claims

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