The invention relates to nanometer high-weatherability colorful eco-friendly paint. The nanometer high-weatherability colorful eco-friendly paint comprises a pigment component, a disperse medium and varnish. The pigment component comprises RO water cellulose, an emulsion, a dispersant, pigment and filling materials, a nanometer anti-aging agent, an antifoaming agent, a nanometer stain-resistant agent, a film forming auxiliary agent, an antifreezing agent, an inorganic protection glue solution, a pH adjustment agent, a bactericide and a first thickening agent. The disperse medium comprises RO water, a film forming auxiliary agent, a rheological agent, an emulsion, an organic protection glue solution, an antifoaming agent, an inorganic protection glue solution and a coupling agent. The varnish comprises RO water, an emulsion, a nanometer anti-aging agent, a pH adjustment agent, a bactericide, an antifoaming agent, a film forming auxiliary agent, an antifreezing agent and 0.3-1 part of a second thickening agent. Compared with the prior art, the preparation method utilizes the nanometer stain-resistant agent to reduce air organic dust adsorption, realize good coating film self-cleanliness and improve paint stain resistance and utilizes the nanometer anti-aging assistant to improve aging resistance of the aqueous colorful paint.