Preparation method of degradable metal molybdenum and alloy for ureteral and urethral stents

A technology of ureter and alloy, which is applied in the field of medical equipment, to achieve the effect of benefiting the recovery of body function, high mechanical strength, and enhancing the therapeutic effect

Pending Publication Date: 2022-01-21
SHANDONG RIENTECH MEDICAL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a degradable metal molybdenum and alloy for ureter and urethral stent, which solves urethral stricture and prevents postoperative complications, and at the same time provides a non-adverse effect on the body and urethral tissue; good compliance , easy to place in urethral strictures; urethral stent with good tissue biocompatibility

Method used

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  • Preparation method of degradable metal molybdenum and alloy for ureteral and urethral stents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Alloy 1-molybdenum-zinc-iron-magnesium quaternary alloy

[0034] The material of the degradable metal molybdenum and alloy used in the ureter and urethral stent in this embodiment is a molybdenum-zinc-iron-magnesium alloy, and the preparation process specifically includes the following steps:

[0035]Ball milling: 0.3wt% Zn, 0.5wt% Fe, 0.2wt% Mg of high purity (99.999%), and the rest are Mo powder (R≤30μm), weighed according to a certain mass ratio. Mix the weighed powder evenly in a high-energy ball mill, and the mass ratio of ball to material is 10:1. Vacuumize the ball milling tank with the powder in turn with a vacuum pump, and then pass in argon to fill the whole ball milling tank. The operation mode of the ball mill was set to run forward and reverse alternately at intervals, the speed was 400-600 r / min, and the total time of ball milling was 10-48 h.

[0036] Vacuum melting: Repeated vacuuming 2-4 times to 6×10 -2 Pa-5×10 -3 Pa, close the valve ...

Embodiment 2

[0041] Embodiment 2: alloy 2-molybdenum-zinc-iron-magnesium-copper quinary alloy

[0042] The degradable metal molybdenum and alloys used in the ureter and urethral stent in this embodiment are made of molybdenum-zinc-iron-magnesium-copper alloy, and the preparation process specifically includes the following steps:

[0043] Ball milling: High-purity (99.99%) 17wt%Zn, 6wt%Fe, 17wt%Mg, 15wt%Cu, and the rest are Mo powder (R≤30 μm), weighed according to a certain mass ratio. Mix the weighed powder evenly in a high-energy ball mill, and the mass ratio of ball to material is 10:1. Vacuumize the ball milling tank with the powder in turn with a vacuum pump, and then pass in argon to fill the whole ball milling tank. The operation mode of the ball mill was set to run forward and reverse alternately at intervals, the speed was 400-600 r / min, and the total time of ball milling was 10-48 h.

[0044] Vacuum melting: Repeated vacuuming 2-4 times to 6×10 -2 Pa-5×10 -3 Pa, close the val...

Embodiment 3

[0049] Example 3: Alloy 3-molybdenum-zinc-copper-magnesium quaternary alloy

[0050] The material of the degradable metal molybdenum and alloy used in the ureter and urethral stent in this embodiment is a molybdenum-zinc-copper-magnesium alloy. The preparation process specifically includes the following steps:

[0051] Ball milling: high-purity (99.99%) 10wt% Zn, 8.5wt% Mg, 7.5wt% Cu, and the rest Mo powder (R≤30 μm), weighed according to a certain mass ratio. Mix the weighed powder evenly in a high-energy ball mill, and the mass ratio of ball to material is 10:1. Vacuumize the ball milling tank with the powder in turn with a vacuum pump, and then pass in argon to fill the whole ball milling tank. The operation mode of the ball mill is set to run forward and reverse alternately at intervals, the speed is 400-600 r / min, and the total time of ball milling is 10-48h.

[0052] Vacuum melting: Repeated vacuuming 2-4 times to 6×10 -2 Pa-5×10 -3 Pa, close the valve of the furnace...

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Abstract

The invention discloses a preparation method of degradable metal molybdenum and alloy for ureteral and urethral stents. The alloy comprises the following components in percentage by mass: 0.2-17 wt% of Zn, 0-6 wt% of Fe, 0.2-17 wt% of Mg and 0-15 wt% of Cu, and the rest metal is Mo. The elements such as Mo, Zn, Fe, Mg, Cu and the like are uniformly mixed, and vacuum arc melting is performed to obtain the alloy. The molybdenum-based alloy has good mechanical properties and is easy to process, and the properties such as strength, toughness and plasticity meet the requirements of human body implant materials for biliary tracts and the like. The surface of the stent is coated with anti-stenosis, anti-urethral infection, antibacterial and other polymer drugs. The five elements of Mo, Zn, Fe, Mg and Cu are the elements necessary for a human body, magnesium is an activating agent and an auxiliary factor of various enzymes, zinc ions participate in in-vivo balance and immune reaction, iron is a main substance for maintaining life and is an important component of hemoglobin of the human body, a degradation product of copper has a certain antibacterial effect, and molybdenum can prevent anemia and promote development. The molybdenum-based alloy ureteral and urethral stent has good biological performance, and the degradation process and the product are safe and effective to a matrix.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to a preparation method for degradable metal molybdenum and alloys used in ureter and urethral stents. Background technique [0002] Ureteral stents are the most commonly used stents in urology. In recent years, the application of stents in urethral strictures has been increasing. According to the material, it can be divided into metal and non-metal stents; according to the degradation properties, it can be divided into degradable and non-degradable stents; according to the placement time, it can be divided into permanent and temporary stents. In a broad sense, as long as the urethral stricture has undergone preliminary treatment and the urethral lumen has been enlarged to be close to normal, a urethral stent can be placed to prevent the stricture from recurring. Its contraindications: acute urethral inflammation; those with diverticulum, urethral fistula, blood disease and those who c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C27/04C22C1/02A61L31/02A61L31/14A61L31/16
CPCC22C27/04C22C1/02A61L31/022A61L31/148A61L31/16
Inventor 张海军周广泰周超初同超
Owner SHANDONG RIENTECH MEDICAL TECH
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